Regional and racial disparity in proximal gastric cancer survival outcomes 1996–2016: Results from SEER and China National Cancer Center database

Zhao, Lulu; Niu, Penghui; Zhao, Dongbing; Chen, Yingtai

doi:10.1002/cam4.4033

Cited by 17 publications

(15 citation statements)

References 24 publications

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“…As Kaplan-Meier curves illustrated, the prognosis of GCC patient in SEER database was worse than that of NGCC patients, while it was not the worst in the Chinese data, which was similar to previous studies [5,26]. Some researchers reported that these differences might be related to the surgical method and the number of lymph node resection [27,28], but more studies still required.…”

Section: Discussionsupporting

confidence: 83%

“…In the past half century, the incidence of NGCC has decreased, which was replaced by the high incidence of GCC worldwide [3,4]. Black and white ethnicity with GCC had a higher mortality rate than yellow ethnicity, and the eastern region had a better prognosis than the western region globally [5]. It has been reported that the prognosis of GCC was potentially different from that of NGCC [6].…”

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confidence: 99%

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Neural network-based prognostic predictive tool for gastric cardiac cancer: the worldwide retrospective study

Zhang

Cai

et al. 2022

Preprint

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Background: Gastric cancer (GC) is one of the most common cancers and the main cause of tumor-related death worldwide. Moreover, the incidence of gastric cardiac cancer (GCC) has increased obviously, with the potentially different prognosis from other sites of GC (non-gastric cardiac cancer, NGCC). We will analyze the prognosis between GCC and NGCC, and set up an effective prognostic model based on neural network for GCC. Methods: In the population-based cohort study, we firstly enrolled the clinical features from the Surveillance, Epidemiology and End Results (SEER) data (n=31397) as well as the public Chinese data from different hospitals (n=1049). Then according to the diagnostic time, the SEER data were then divided into two cohorts, the train cohort (patients were diagnosed as GCC in 2010-2014, n=4414) and the test cohort (diagnosed in 2015, n=957). Age, sex, pathology, tumor, node, and metastasis (TNM) stage, tumor size, surgery or not, radiotherapy or not, chemotherapy or not and history of malignancy were chosen as the predictive clinical features. Results: The prognosis of GCC patients in SEER database was worse than that of NGCC patients, while it was not worst in the Chinese data. The total of 5371 patients were used to conduct the development model, following inclusion and exclusion criteria. Neural network-based prognostic predictive model had a satisfactory performance for GCC overall survival (OS) prediction, which owned 0.7431 AUC in the train cohort (95% confidence intervals, CIs, 0.7423-0.7439) and 0.7419 in the test cohort (95% CIs, 0.7411-0.7428). Conclusion: GCC patients indeed have the different survival time compared with NGCC patients. And this neural network-based prognostic predictive tool is a novel and promising software for the outcome of GCC patients.

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Section: Discussionsupporting

confidence: 83%

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confidence: 99%

Neural network-based prognostic predictive tool for gastric cardiac cancer: the worldwide retrospective study

Zhang

Cai

et al. 2022

Preprint

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“…27,28 There are significant regional differences in the incidence of some cancers in our country. 29,30 Hakka In this case-control study, the proportion of subjects with drinking and smoking history in the patients was higher than that in the controls. Overall, individuals in the control group had healthier lifestyles than those in patients.…”

Section: Discussionmentioning

confidence: 54%

“… 27 , 28 There are significant regional differences in the incidence of some cancers in our country. 29 , 30 Hakka population is one of the Chinese Han populations. Since the Song Dynasty, the Hakka ancestors who migrated southward from the central China began to live in the Hakka area in a relatively stable way, and merged with the local indigenous peoples and became Hakka.…”

Section: Discussionmentioning

confidence: 99%

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ALDH2 gene rs671 G > a polymorphism and the risk of colorectal cancer: A hospital‐based study

Zhang

Chen

Qing-Qing

et al. 2022

Clinical Laboratory Analysis

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Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and can occur in any part of the colon, with the rectum and sigmoid colon being the most common. 1 According to the latest global cancer statistics, the incidence (19.5 people per 100,000 people) and mortality (9.0 people per 100,000 people) of CRC rank third and second, respectively. 2 In China, the incidence of CRC increased rapidly, and

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Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young‐ and Average‐Onset Gastric Cancer

Magahis,

Cornet,

Tang

et al. 2024

Cancer Medicine

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BackgroundThere has been a paradoxical rise in young‐onset gastric cancer (YOGC), defined as gastric cancer (GC) diagnosed before age 50. Precursor lesions may contribute to pathogenesis, though their role in progression to different histologic subtypes is unclear. The impact of self‐reported race is also poorly characterized and may be unreliable as a proxy for genetic differences. We aimed to compare differences in histology and genetic ancestry between YOGC and average‐onset gastric cancer (AOGC).MethodsThis retrospective cohort included all patients with GC at Memorial Sloan Kettering (MSK) from January 2013 to March 2021. Data on demographics, tumor characteristics, and precursor lesions were collected. Genetic ancestry was inferred from MSK‐Integrated Mutation Profiling of Actionable Cancer Targets panel.ResultsOf 1685 individuals with GC, 290 had YOGC. Compared to AOGC, individuals with YOGC tended to be female, Hispanic, foreign‐born, and feature diffuse‐type histology. YOGC was less likely to have precursor lesions, including intestinal metaplasia (20% vs. 37%, p < 0.01) and dysplasia (4% vs. 14%, p < 0.01). Of 560 patients with ancestry data, 127 had YOGC. Admixed, East Asian, and South Asian ancestries were more likely to present with YOGC while Europeans presented with AOGC. Intestinal metaplasia was enriched among East Asians, maintained when stratifying by histology and GC onset.ConclusionsWe observed YOGC was more common in East and South Asians, and while YOGC may be less likely to develop in the setting of precursor lesions these high‐risk states may also be enriched in East Asians. Future research is needed to understand drivers behind such differences and outcome disparities given these individuals may be less amenable to endoscopic interventions.

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Regional and racial disparity in proximal gastric cancer survival outcomes 1996–2016: Results from SEER and China National Cancer Center database

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 17 publications

References 24 publications

Neural network-based prognostic predictive tool for gastric cardiac cancer: the worldwide retrospective study

Neural network-based prognostic predictive tool for gastric cardiac cancer: the worldwide retrospective study

ALDH2 gene rs671 G > a polymorphism and the risk of colorectal cancer: A hospital‐based study

Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young‐ and Average‐Onset Gastric Cancer

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