Regional brain atrophy in primary fatigued patients with multiple sclerosis

Andreasen, Anne Katrine; Jakobsen, Johannes; Soerensen, L; Andersen, Henning; Petersen, Thor; Bjarkam, Carsten Reidies; Ahdidan, Jamila

doi:10.1016/j.neuroimage.2009.12.118

Cited by 66 publications

(84 citation statements)

References 50 publications

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“…Our results confirm (8,10,14,26) that global brain damage, quantified in terms of lesion volumes on T2-and T1-weighted images and atrophy of the whole brain, WM, and GM, does not seem to be able to distinguish fatigued Tract-based spatial statistics analysis showed a distributed pattern of FA decrease and mean diffusivity, radial diffusivity, and axial diffusivity increase involving the main WM tracts in patients with MS versus healthy control subjects to explain the phenotypic variability of MS and its heterogeneous clinical manifestations (18,27). In only one study (28) have investigators quantified cortical lesions in patients with MS and fatigue and found no relationship between their presence and volume and this symptom.…”

Section: Discussionsupporting

confidence: 88%

“…In the right ATR, fatigued patients with MS experienced a higher occurrence of focal lesions on T2-weighted images and lower FA values compared with nonfatigued patients with MS. Investigators in previous functional (5,6) and structural (7)(8)(9)26) imaging studies have associated the presence of fatigue in MS with disrupted connectivity between the thalamus and the cortex, particularly that of the frontal lobe (7)(8)(9). Recently, investigators in DT MR imaging studies (29,30) found a correlation between fatigue and abnormal DT MR imaging indexes of the ATR.…”

Section: Discussionmentioning

confidence: 99%

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Regional but Not Global Brain Damage Contributes to Fatigue in Multiple Sclerosis

Rocca¹,

Parisi²,

Pagani³

et al. 2014

Radiology

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Regional but Not Global Brain Damage Contributes to Fatigue in Multiple Sclerosis

Rocca¹,

Parisi²,

Pagani³

et al. 2014

Radiology

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show abstract

“…Although initial studies yielded conflicting results [5,6], recent reports have described an association between fatigue and higher lesion load as well as gray matter (GM) atrophy [7–11]. Regarding whether or not lesion load or GM atrophy in specific brain areas could play a role in the occurrence and clinical characteristics of fatigue, volumetric studies have described alterations in frontal motor areas and certain subcortical areas, such as the thalamus and basal ganglia, that may be especially relevant [12–14]. Accordingly, it has been proposed that MS lesions at circuits relating to motor and premotor functions, and their afferent and efferent connections with several subcortical areas, could be the main substrate of fatigue in this clinical population [13].…”

Section: Introductionmentioning

confidence: 99%

Regional Brain Atrophy and Functional Connectivity Changes Related to Fatigue in Multiple Sclerosis

et al. 2013

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Fatigue is one of the most frequent symptoms in multiple sclerosis (MS), and recent studies have described a relationship between the sensorimotor cortex and its afferent and efferent pathways as a substrate of fatigue. The objectives of this study were to assess the neural correlates of fatigue in MS through gray matter (GM) and white matter (WM) atrophy, and resting state functional connectivity (rs-FC) of the sensorimotor network (SMN). Eighteen healthy controls (HCs) and 60 relapsing-remitting patients were assessed with the Fatigue Severity Scale (FSS). Patients were classified as fatigued (F) or nonfatigued (NF). We investigated GM and WM atrophy using voxel-based morphometry, and rs-FC changes with a seed-based method and independent component analysis (ICA). F patients showed extended GM and WM atrophy focused on areas related to the SMN. High FSS scores were associated with reductions of WM in the supplementary motor area. Seed analysis of GM atrophy in the SMN showed that HCs presented increased rs-FC between the primary motor and somatosensory cortices while patients with high FSS scores were associated with decreased rs-FC between the supplementary motor area and associative somatosensory cortex. ICA results showed that NF patients presented higher rs-FC in the primary motor cortex compared to HCs and in the premotor cortex compared to F patients. Atrophy reduced functional connectivity in SMN pathways and MS patients consequently experienced high levels of fatigue. On the contrary, NF patients experienced high synchronization in this network that could be interpreted as a compensatory mechanism to reduce fatigue sensation.

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“…A structural MRI study found that fatigue in multiple sclerosis is associated with atrophy of the caudate head [16]. Similarly, positron emission tomography (PET) revealed that fatigue in Parkinson's disease is linked to dopamine dysfunction only in the caudate [17].…”

Section: Introductionmentioning

confidence: 99%