Regional difference in the distribution of parvalbumin-containing neurons immunoreactive for monoclonal antibody HNK-1 in the mouse cerebral cortex

Ren, Jujie; Heizmann, Claus W.; Kosaka, Toshio

doi:10.1016/0304-3940(94)90490-1

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…It has been shown that a subpopulation of interneurons immunopositive for the Ca 2+ -binding protein parvalbumin can also be revealed by HNK-1 immunostaining (Yamamoto et al, 1988;Ren et al, 1994;Weber et al, 1999). In the hippocampus the somata of these interneurons, classi®ed as basket and axo-axonic cells, are located in the strata oriens and pyramidale of the CA1±3 regions with dense axonal arborizations in the pyramidal cell layer and proximal stratum oriens (Freund & Buzsaki, 1996).…”

Section: Hnk-1 Immunostaining In the Ca1 Region Of Murine Hippocampusmentioning

confidence: 99%

“…Interestingly, perisomatic interneurons show high HNK-1 carbohydrate immunoreactivity (Yamamoto et al, 1988;Ren et al, 1994;Weber et al, 1999). The HNK-1 carbohydrate, a 3¢-sulphated glucuronic acid recognized by a monoclonal antibody (Abo & Balch, 1981), is expressed by many adhesion molecules (Kruse et al, 1984), including those of the immunoglobulin (Ig) superfamily, such as the neural cell adhesion molecule (NCAM) (Kruse et al, 1984), P0 (Voshol et al, 1996), L1 (Faissner, 1987) and F3/F11/contactin (Gennarini et al, 1990), as well as integrins (Pesheva et al, 1987), proteoglycans (Gowda et al, 1989Xiao et al, 1997) and the extracellular matrix glycoproteins tenascin-C and tenascin-R (Kruse et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

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The extracellular matrix molecule tenascin‐R and its HNK‐1 carbohydrate modulate perisomatic inhibition and long‐term potentiation in the CA1 region of the hippocampus

Saghatelyan

Gorissen

Albert

et al. 2000

Eur J of Neuroscience

110

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Perisomatic inhibition of pyramidal cells regulates efferent signalling from the hippocampus. The striking presence of HNK-1, a carbohydrate expressed by neural adhesion molecules, on perisomatic interneurons and around somata of CA1 pyramidal neurons led us to apply monoclonal HNK-1 antibodies to acute murine hippocampal slices. Injection of these antibodies decreased GABAA receptor-mediated perisomatic inhibitory postsynaptic currents (pIPSCs) but did not affect dendritic IPSCs or excitatory postsynaptic currents. The decrease in the mean amplitude of evoked pIPSCs by HNK-1 antibodies was accompanied by an increase in the coefficient of variation of pIPSC amplitude, number of failures and changes in frequency but not amplitude of miniature IPSCs, suggesting that HNK-1 antibodies reduced efficacy of evoked GABA release. HNK-1 antibodies did not affect pIPSCs in knock-out mice deficient in the extracellular matrix molecule tenascin-R which carries the HNK-1 carbohydrate as analysed by immunoblotting in synaptosomal fractions prepared from the CA1 region of the hippocampus. For control, HNK-1 antibody was applied to acute sections of mice deficient in the neural cell adhesion molecule NCAM, another potential carrier of HNK-1, and resulted in decrease of pIPSCs as observed in wild-type mice. Reduction in perisomatic inhibition is expected to promote induction of long-term potentiation (LTP) by increasing the level of depolarization during theta-burst stimulation. Indeed, LTP was increased by HNK-1 antibody applied before stimulation. Moreover, LTP was reduced by an HNK-1 peptide mimic, but not control peptide. These results provide first evidence that tenascin-R and its associated HNK-1 carbohydrate modulate perisomatic inhibition and synaptic plasticity in the hippocampus.

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Section: Hnk-1 Immunostaining In the Ca1 Region Of Murine Hippocampusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The extracellular matrix molecule tenascin‐R and its HNK‐1 carbohydrate modulate perisomatic inhibition and long‐term potentiation in the CA1 region of the hippocampus

Saghatelyan

Gorissen

Albert

et al. 2000

Eur J of Neuroscience

110

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“…Staining produced by these two antibodies is identical and both label PNNs ensheathing a subpopulation of neocortical GABAergic neurons that express the calcium-binding protein parvalbumin (Kosaka et al, 1990). HNK-1-positive PNNs also ensheath PV+ interneurons in the hippocampus (Ren et al, 1994; Weber et al, 1999). Studies in the hippocampus have shown that tenascin-R molecules carrying the VC1.1/HNK-1 carbohydrate epitope modulate perisomatic inhibition and long-term potentiation (Saghatelyan et al, 2000, 2001; Bukalo et al, 2001)…”

Section: Introductionmentioning

confidence: 99%

Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

2017

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Perineuronal nets (PNNs) are specialized condensations of extracellular matrix that ensheath particular neuronal subpopulations in the brain and spinal cord. PNNs regulate synaptic plasticity, including the encoding of fear memories by the amygdala. The present immunohistochemical investigation studied PNN structure and distribution, as well as the neurochemistry of their ensheathed neurons, in the rat amygdala using monoclonal antibody VC1.1, which recognizes a glucuronic acid 3-sulfate glycan associated with PNNs in the cerebral cortex. VC1.1+ PNNs surrounded the cell bodies and dendrites of a subset of nonpyramidal neurons in cortex-like portions of the amygdala (basolateral amygdalar complex, cortical nuclei, nucleus of the lateral olfactory tract, and amygdalohippocampal region). There was also significant neuropilar VC1.1 immunoreactivity whose density varied in different amygdalar nuclei. Cell counts in the basolateral nucleus revealed that virtually all neurons ensheathed by VC1.1+ PNNs were parvalbumin-positive (PV+) interneurons, and these VC1.1+/PV+ cells constituted 60% of all PV+ interneurons, including all of the larger PV+ neurons. Approximately 70% of VC1.1+ neurons were calbindin-positive (CB+), and these VC1.1+/CB+ cells constituted about 40% of all CB+ neurons. Colocalization of VC1.1 with Vicia villosa agglutinin (VVA) binding, which stains terminal N-acetylgalactosamines, revealed that VC1.1+ PNNs were largely a subset of VVA+ PNNs. This investigation provides baseline data regarding PNNs in the rat which should be useful for future studies of their function in this species.

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Biological Functions of EF-Hand Ca2+-Binding Proteins

Heizmann

Braun

1995

Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

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Regional difference in the distribution of parvalbumin-containing neurons immunoreactive for monoclonal antibody HNK-1 in the mouse cerebral cortex

Cited by 8 publications

References 15 publications

The extracellular matrix molecule tenascin‐R and its HNK‐1 carbohydrate modulate perisomatic inhibition and long‐term potentiation in the CA1 region of the hippocampus

The extracellular matrix molecule tenascin‐R and its HNK‐1 carbohydrate modulate perisomatic inhibition and long‐term potentiation in the CA1 region of the hippocampus

Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

Biological Functions of EF-Hand Ca2+-Binding Proteins

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