Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011

Minami, Takafumi; Fukutomi, Yuma; Inada, Reiko; Tsuda, Manabu; Sekiya, Kiyoshi; Miyazaki, Masaki; Tsuji, Fumio; Taniguchi, Masami

doi:10.1016/j.alit.2019.03.008

Cited by 26 publications

(21 citation statements)

References 36 publications

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“…Regional differences in sensitisation rates, even for closely related taxa, based on analysis of large Japanese IgE data sets have been recently reported. 25 These findings reinforce that clinical interpretation of spIgE responses needs to be correlated with symptoms upon exposure and the allergens likely to be encountered by the patient within their usual environment.…”

Section: Discussionsupporting

confidence: 64%

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

Kailaivasan

Timbrell

Solley³

et al. 2020

Clin & Trans Imm

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Objective Globally, grass pollens (GP) are major aeroallergen triggers of allergic rhinitis (AR) and asthma. However, patterns of allergic sensitisation to pollen of temperate (Pooideae: Lolium perenne) and subtropical (Chloridoideae: Cynodon dactylon and Panicoideae: Paspalum notatum) subfamilies in diverse climates remain unclear. This study aims to evaluate the level of allergic sensitisation and IgE specificity for major GP allergens representing the three subfamilies in biogeographically distinct regions. Methods Participants (GP‐allergic with AR, 330; non‐atopic, 29; other allergies, 54) were recruited in subtropical: Queensland, and temperate: New South Wales, Western and South Australia, regions. Clinical history, skin prick test (SPT), total and specific IgE to GP and purified allergens (ImmunoCAP) were evaluated. Cross‐inhibition of sIgE with Pas n 1, Cyn d 1 and Lol p 1 by GP extracts was investigated. Results Queensland participants showed higher sensitisation to P. notatum and C. dactylon than L. perenne GP. sIgE was higher to Pas n 1 and Cyn d 1, and sIgE to Pas n 1 and Cyn d 1 was inhibited more by Panicoideae and Chloridoideae, respectively, than Pooideae GP. Conversely, participants from temperate regions showed highest sensitisation levels to L. perenne GP and Lol p 1, and sIgE to Lol p 1 was inhibited more by Pooideae than other GP. Conclusion Levels and patterns of sensitisation to subtropical and temperate GP in AR patients depended on biogeography. Knowledge of the specificity of sensitisation to local allergens is important for optimal diagnosis and choice of allergen‐specific immunotherapy to maximise benefit.

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Section: Discussionsupporting

confidence: 64%

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

Kailaivasan

Timbrell

Solley³

et al. 2020

Clin & Trans Imm

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“…The positivity for cockroach-speci c IgE in COPD has been reported to be comparable to the positivity in asthma, but higher than in the control group [17][18][19]. In addition, no signi cant difference in positivity of cockroach-speci c IgE was observed between ACO and non-ACO COPD in this study (Table 1).…”

Section: Discussionsupporting

confidence: 63%

“…In addition to our current ndings, the general importance of mite-speci c IgE in the diagnosis or pathology of ACO was suggested. Although geographical variation in the positivity of speci c IgE may exist, sensitization to D. pteronyssinus was most prevalent among various developed countries [31] and different areas in Japan [19]. It remains unclear whether ACO diagnosed from clinical asthma and clinical COPD has identical pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Toyota

Sugimoto

Kobayashi

et al. 2020

Preprint

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Background Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD pathology is unclear. This study aimed to identify the specific IgE related to clinical features of COPD and the diagnosis of asthma-COPD overlap (ACO). Methods We recruited 70 patients with COPD and analyzed 39 IgE using panel IgE test (View Allergy 39®). ACO was diagnosed according to the Japanese Respiratory Society Guidelines. Results As for perennial aeroallergens, the positivity for moth (35.4%), cockroach (23.1%), Dermatophagoides pteronyssinus (21.5%), house dust (21.5%), and Candida (21.5%) and, concerning pollen, Japanese cedar (36.9%) and Japanese cypress (23.1%) exceeded 20%. Only the positivity of IgE for Dermatophagoides pteronyssinus and house dust was significantly higher in ACO compared with that in non-ACO COPD. Moreover, it contributed to the diagnosis of ACO in an IgE class-dependent manner. Patients with cockroach IgE exhibited higher residual volume, whereas those with Japanese cedar IgE exhibited better diffusion capacity than negative patients. The contribution for ACO diagnosis by the receiver operating characteristic curve analysis was comparable among total IgE (cutoff value: 158 IU/mL), blood eosinophil count (234/µl), and fraction of exhaled nitric oxide (31.0 ppb). Conclusions The prominent role of mite-specific IgE in the diagnosis and pathology of ACO and the potentially detrimental effect of cockroach sensitization on air trapping in COPD were suggested. The finding highlights the future development of a treatment targeting IgE as a treatable trait in COPD.

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“…The positivity for cockroach-speci c IgE in COPD has been reported to be comparable to the positivity in asthma, but higher than in the control group (13,18,19). In addition, no signi cant difference in positivity of cockroachspeci c IgE was observed between ACO and non-ACO COPD in this study (Table 1).…”

Section: Discussionsupporting

confidence: 63%

“…NIOX VERO® (Aerocrine, Morrisville, NC, USA) was used to measure FeNO. The panel IgE test includes speci c IgE for pollens or molds, which are shown to be highly prevalent in Japan (13).…”

Section: Study Design and Patient Populationmentioning

confidence: 99%

Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Toyota

Sugimoto

Kobayashi

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD pathology is unclear. This study aimed to identify the specific IgE related to clinical features of COPD and the diagnosis of asthma-COPD overlap (ACO).Methods: We recruited 76 patients with COPD and analyzed 39 IgE using panel IgE test (View Allergy 39®). ACO was diagnosed according to the Japanese Respiratory Society Guidelines.Results: As for perennial aeroallergens, the positivity for moth (31.5%), Candida (23.7%), Dermatophagoides pteronyssinus (22.4%) and house dust (22.4%), and concerning pollen, Japanese cedar (35.5%) and Japanese cypress (22.2%) exceeded 20%. Only the positivity of IgE for Dermatophagoides pteronyssinus and house dust was significantly higher in ACO compared with that in non-ACO COPD. Moreover, it contributed to the diagnosis of ACO in an IgE class-dependent manner. Patients with cockroach IgE exhibited higher residual volume, whereas those with Japanese cedar IgE exhibited better diffusion capacity than negative patients. The contribution for ACO diagnosis by the receiver operating characteristic curve analysis was comparable among total IgE (cutoff value: 158 IU/mL), blood eosinophil count (234/μl), and fraction of exhaled nitric oxide (31.0 ppb).Conclusions: The prominent role of mite-specific IgE in the diagnosis and pathology of ACO and the potentially detrimental effect of cockroach sensitization on air trapping in COPD were suggested. The finding highlights the future development of a treatment targeting IgE as a treatable trait in COPD.

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Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011

Cited by 26 publications

References 36 publications

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

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