Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat

Cenci, M. Angela; Kalén, Peter; Mandel, Ronald J.; Björklund, Anders

doi:10.1016/0006-8993(92)90711-h

Cited by 201 publications

(94 citation statements)

References 53 publications

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“…The current studies demonstrate that HCRT elicits an activation of PFC DA systems comparable to that observed in both aversive and appetitive high-arousal states (Abercrombie et al, 1989;Cenci et al, 1992;Gresch et al, 1994;Di Chiara et al, 1999;Feenstra et al, 2000), and that this involves, at least in part, actions within the VTA. These observations suggest that HCRT contributes to the relatively selective activation of PFC DA projections under appetitive and/or aversive conditions.…”

Section: Hcrt-da Interactions In Aversive and Appetitive Conditionssupporting

confidence: 59%

“…These observations suggest that HCRT contributes to the relatively selective activation of PFC DA projections under appetitive and/or aversive conditions. It should be noted that, often, stress-related increases in PFC DA release are accompanied by smaller, though substantial, increases in Acc DA release (Abercrombie et al, 1989;Cenci et al, 1992;Gresch et al, 1994;Di Chiara et al, 1999;Feenstra et al, 2000). Thus, the effect of HCRT-1 on DA neurotransmission is not entirely similar to that observed in stress.…”

Section: Hcrt-da Interactions In Aversive and Appetitive Conditionsmentioning

confidence: 97%

“…In particular, DA terminals within the PFC display the greatest sensitivity to both appetitive and aversive (eg stress) conditions (Thierry et al, 1976;Dunn, 1988;Roth et al, 1988;Cenci et al, 1992). Under similar conditions, Acc DA terminals typically display reduced, and striatal terminals minimal, reactivity (Dunn, 1988;Abercrombie et al, 1989;Cenci et al, 1992). Each of these regions support a variety of distinct cognitive and affective processes.…”

Section: Introductionmentioning

confidence: 99%

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Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Vittoz

Berridge

2005

Neuropsychopharmacol

172

114

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Hypocretins (HCRTs) modulate a variety of behavioral and physiological processes, in part via interactions with multiple ascending modulatory systems. Further, HCRT efferents from the lateral hypothalamus innervate midbrain dopamine (DA) nuclei, and DA cell bodies express HCRT receptors. Combined, these observations suggest that HCRT may influence behavioral state and/or statedependent processes via modulation of DA neurotransmission. The current studies used in vivo microdialysis in the unanesthetized rat to first characterize the effect of intracerebroventricular infusion of HCRT-1 (0.07, 0.7 nmol) on extracellular levels of DA within the prefrontal cortex (PFC) and nucleus accumbens (Acc). Electroencephalographic/electromyographic measures of sleep-wake state were collected along with select behavioral measures (eg locomotor activity, grooming). HCRT-1 dose-dependently increased PFC dialysate DA levels, and these increases were closely correlated with increases in time spent awake. In contrast, Acc DA levels were unaffected. Additional studies examined whether HCRT-1 acts directly within the ventral tegmental area (VTA) to selectively increase PFC DA efflux and modulate behavioral state. Unilateral infusion of HCRT-1 (0.1, 1.0 nmol) within the VTA increased PFC, but not Acc, DA levels. Importantly, intra-VTA infusion of HCRT-1 increased the time spent awake and grooming. Moreover, HCRT-induced increases in both time spent awake and time spent grooming were significantly correlated with post-infusion PFC DA levels. The current observations predict a prominent modulatory influence of HCRT on PFC-dependent cognitive and affective processes that results, in part, from actions within the VTA. Additionally, these observations suggest that the activation of VTA DA neurons contributes to the behavioral state-modulatory actions of HCRT.

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Section: Hcrt-da Interactions In Aversive and Appetitive Conditionssupporting

confidence: 59%

Section: Hcrt-da Interactions In Aversive and Appetitive Conditionsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Vittoz

Berridge

2005

Neuropsychopharmacol

172

114

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“…Elevations of PFC NA levels in response to stimuli that predict a reward have been shown previously (Mingote et al, 2004). It is known that food restriction or presentation of highly palatable food causes an increase in PFC NA efflux (Cenci et al, 1992;Taber and Fibiger, 1997;Feenstra, 2000;Feenstra et al, 2000). In alternationuntrained animals, we observed moderate elevations of NA levels during the task, but conditioned stimuli signaling reward do not contribute to these levels because no increase in NA efflux was observed in either group when animals were placed in the waiting cage before visiting the maze.…”

Section: Discussionmentioning

confidence: 87%

Noradrenaline and Dopamine Elevations in the Rat Prefrontal Cortex in Spatial Working Memory

Rossetti¹,

Carboni²

2005

J. Neurosci.

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The role of prefrontal cortical dopamine (DA) in the modulation of working memory functions is well documented, but substantial evidence indicates that the locus ceruleus noradrenergic system also modulates working memory via actions within the prefrontal cortex (PFC). This study shows that PFC noradrenaline (NA) and DA dialysate levels phasically increase when rats perform correctly in a delayed alternation task in a T-maze, a test of spatial working memory. However, NA levels were markedly enhanced in animals trained to alternate compared with rats that acquired the spatial information about the location of food in the maze but were untrained to make a choice to obtain the reward. In contrast, PFC DA elevations occurred independently of whether the animal had acquired the trial-specific information for correct task execution. The contribution of anticipatory responses to catecholamine efflux was also evaluated by exposing rats to an environment signaling the presence of the reward in the successive alternation task. No conditioned NA efflux was observed in either group. In contrast, in both groups, DA efflux increased in the anticipatory phase of the test to the same levels of those reached during the task. These data provide the first direct evidence for a selective activation of PFC NA transmission during a spatial working memory task. We propose that, in the working memory task, DA is primarily associated with reward expectancy, whereas NA is involved in the active maintenance of the information about a goal and the rules to achieve it.

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“…Conversely, anatomical and electrophysiological studies indicate the existence of an efferent pathway originating in the amygdala, synapsing within the periaquaductal gray and continuing on to the spinal cord dorsal horn that modulates pain (Hopkins and Holstege 1978;Krettek and Price 1978;Beitz 1982;Watson et al, 1983;Zhang et al, 1991;Bernard et al, 1996;Manning 1998). In addition, the basal ganglia receives nociceptive information through several sources including the amygdala, cingulate cortex, prefrontal cortex and the habenula (Ma and Han, 1991;Cenci et al, 1992;Ma et al, 1992;Chudler and Dong, 1995).…”

Section: Paraventricular Nucleus Of the Hypothalamus-previous Researcmentioning

confidence: 99%

Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat

Paulson

Morrow

Casey

2000

Pain

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A unilateral chronic constriction injury (CCI) of the sciatic nerve produced bilateral effects in both pain related behaviors and in the pattern of forebrain activation. All CCI animals exhibited spontaneous pain-related behaviors as well as bilateral hyperalgesia and allodynia after CCI. Further, we identified changes in baseline (unstimulated) forebrain activation patterns 2 weeks following CCI by measuring regional cerebral blood flow (rCBF). Compared to controls, CCI consistently produced detectable, well-localized and typically bilateral increases in rCBF within multiple forebrain structures in unstimulated animals. For example, the hindlimb region of somatosensory cortex was significantly activated (22%) as well as multiple thalamc nuclei, including the ventral medial (8%), ventral posterior lateral (10%) and the posterior (9%) nuclear groups. In addition, several forebrain regions considered to be part of the limbic system showed pain-induced changes in rCBF, including the anterior dorsal nucleus of the thalamus (23%), cingulate cortex (18%), retrosplenial cortex (30%), habenular complex (53%), interpeduncular nucleus (45%) and the paraventricular nucleus of the hypothalamus (30%). Our results suggest that bilateral somatosensory and limbic forebrain structures participate in the neural mechanisms of prolonged persistent pain produced by a unilateral injury. Published for the International Association for the Study of Pain by Elsevier Science B.V.

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Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat

Cited by 201 publications

References 53 publications

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Noradrenaline and Dopamine Elevations in the Rat Prefrontal Cortex in Spatial Working Memory

Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat

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