Regional diffusion changes of cerebral grey matter during normal aging—A fluid-inversion prepared diffusion imaging study

Ni, Jianming; Chen, Shuang; Liu, Jianjun; Huang, Gang; Shen, Tian-zhen; Chen, Xingrong

doi:10.1016/j.ejrad.2009.04.028

Cited by 25 publications

(26 citation statements)

References 31 publications

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“…Also, the subject population that we sampled was a highly educated, right-handed one narrowly restricted to young adults. Thus, the results we obtained may not generalize to older populations where DTI scalar values change in regionally specific ways due to aging [49,50].…”

Section: Limitationsmentioning

confidence: 52%

Diffusion properties of cortical and pericortical tissue: regional variations, reliability and methodological issues

Kang

Herron

Turken

et al. 2012

Magnetic Resonance Imaging

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Section: Limitationsmentioning

confidence: 52%

Diffusion properties of cortical and pericortical tissue: regional variations, reliability and methodological issues

Kang

Herron

Turken

et al. 2012

Magnetic Resonance Imaging

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“…MD is often believed to be a measure of overall water content (Moseley et al, 2002). Possible obstacles, such as the presence of fewer or smaller cellular structures (e.g., capillaries, synapses, and macromolecular proteins), may prevent the free diffusion of water molecules and may also be expected to cause a decrease in the MD value (Ni et al, 2010). Among normal samples, cognitive learning affects MD values after only 2 h of training in the relevant tissues and together with the results of animal experiments, an increase in the number of synaptic vesicles and swelling of astrocytes because of the increased activity has been suggested to underlie these MD changes (Johansen-Berg et al, 2012;Sagi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele

et al. 2015

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The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence. In this study, we investigated the effect of this allele on microstructural properties of the brain and on its functional activity during externally directed attention-demanding tasks and creative performance in the 765 Asian subjects. For this purpose, we employed diffusion tensor imaging, N-back functional magnetic resonance imaging paradigms, and a test to measure creativity by divergent thinking. The 5-repeat allele was significantly associated with increased originality in the creative performance, increased mean diffusivity (the measure of how the tissue includes water molecules instead of neural and vessel components) in the widespread gray and white matter areas of extensive areas, particularly those where DRD4 is expressed, and reduced task-induced deactivation in the areas that are deactivated during the tasks in the course of both the attention-demanding working memory task and simple sensorimotor task. The observed neural characteristics of 5-repeat allele carriers may lead to an increased risk of ADHD and behavioral deficits. Furthermore, the increased originality of creative thinking observed in the 5-repeat allele carriers may support the notion of the side of adaptivity of the widespread risk allele of psychiatric diseases.

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“…In contrast, a greater tissue density, such as the presence of more cellular structures [e.g., capillaries, synapses, and macromolecular proteins; the shape of neurons or glia; or enhanced tissue organization (strengthening of the axonal or dendritic backbones and surrounding tissue)], may prevent the free diffusion of water molecules and may also be expected to cause the MD value to decrease (Assaf and Pasternak 2008;Ni et al 2010;Sagi et al 2012). MD differences have been shown to underlie individual cognitive differences and brain pathology (Laricchiuta et al 2013;Piras et al 2010).…”

Section: Introductionmentioning

confidence: 88%

Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states

et al. 2016

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Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.

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Regional diffusion changes of cerebral grey matter during normal aging—A fluid-inversion prepared diffusion imaging study

Cited by 25 publications

References 31 publications

Diffusion properties of cortical and pericortical tissue: regional variations, reliability and methodological issues

Diffusion properties of cortical and pericortical tissue: regional variations, reliability and methodological issues

Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele

Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states

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