Regional effects of age and sex in magnetic resonance spectroscopy

Santos, J.M. García; Fuentes, Luis J.; Vidal, Juan Bautista; Antequera, Martirio; Río, Silvia Torres del; Antúnez, Carmen; Ortega, G.

doi:10.1016/s2173-5107(10)70023-9

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…In the adult population, both SVS and MRSI studies have reported sex differences in regional cortical gray matter and/or white matter for both NAA and myo-inositol ( 93 , 108 – 113 ). However, other work shows no differences in metabolite levels between sexes in the healthy adult population ( 114 – 118 ).…”

Section: Biological Factorsmentioning

confidence: 99%

Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

et al. 2023

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Magnetic resonance spectroscopy is a powerful, non-invasive, quantitative imaging technique that allows for the measurement of brain metabolites that has demonstrated utility in diagnosing and characterizing a broad range of neurological diseases. Its impact, however, has been limited due to small sample sizes and methodological variability in addition to intrinsic limitations of the method itself such as its sensitivity to motion. The lack of standardization from a data acquisition and data processing perspective makes it difficult to pool multiple studies and/or conduct multisite studies that are necessary for supporting clinically relevant findings. Based on the experience of the ENIGMA MRS work group and a review of the literature, this manuscript provides an overview of the current state of MRS data harmonization. Key factors that need to be taken into consideration when conducting both retrospective and prospective studies are described. These include (1) MRS acquisition issues such as pulse sequence, RF and B0 calibrations, echo time, and SNR; (2) data processing issues such as pre-processing steps, modeling, and quantitation; and (3) biological factors such as voxel location, age, sex, and pathology. Various approaches to MRS data harmonization are then described including meta-analysis, mega-analysis, linear modeling, ComBat and artificial intelligence approaches. The goal is to provide both novice and experienced readers with the necessary knowledge for conducting MRS data harmonization studies.

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Section: Biological Factorsmentioning

confidence: 99%

Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

et al. 2023

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Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (<sup>1 </sup>HMRS)

et al. 2018

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PurposeThe aim of this 1HMRS study was to define sex-related differences in metabolic spectrum between healthy children. Forty-nine girls and boys aged 6-15 years were examined.Material and methodsVolume of interest was located in seven brain regions: frontal lobes, basal ganglia, hippocampi, and cerebellum.ResultsStatistical analysis of the results showed significantly higher (p < 0.05) myo-inositol concentrations relative to the total concentrations in the boys than the girls, as well as higher absolute N-acetyl aspartate concentrations in the left frontal lobes in girls. No other significant differences were shown, except for trends in differences.ConclusionsIn clinical practice the diagnostic process first of all focuses on assessing concentrations of metabolites to relative cerebellum concentration. Thus, the findings of the present study allow the conclusion that when analysing the results of 1HMRS studies in children it is not necessary to take into account the child’s gender.

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Regional effects of age and sex in magnetic resonance spectroscopy

Cited by 2 publications

References 36 publications

Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (<sup>1 </sup>HMRS)

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