Regional Hemodynamic Adaptation During the Menstrual Cycle

Ziegler, William F.; Bernstein, Ira M.; Badger, Gary J.; Leavitt, Thomas; CERRERO, MARY LOU

doi:10.1097/00006250-199911000-00010

Cited by 28 publications

(40 citation statements)

References 18 publications

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“…One day after ovulation, uterine perfusion gradually increased. This pattern was similar to those described in women (Ziegler et al 1999), cows (Bollwein et al 2000) mares (Bollwein et al 1998, Bollwein et al 2002 and capuchin monkeys (Domingues et al 2007).…”

Section: Discussionsupporting

confidence: 88%

“…The uterine arteries of infertile women showed increased resistance during the midluteal phase compared with those in fertile controls. Pregnancy rates were reduced during cycles with elevated uterine resistance (Ziegler et al 1999). In the present study, a decrease in uterine blood perfusion was observed two days prior to ovulation.…”

Section: Discussionsupporting

confidence: 53%

“…Knowledge about the uterine and ovarian ultrasonographic features as well their arterial blood flow patterns in cyclical bitches is important. Combining Doppler and ultrasound may also allow the detection of infertility that can be related to poor uterine and ovarian perfusion, since the blood is responsible for delivering hormones and nutrition support to the organs (Ziegler et al 1999, Acosta & Miyamoto 2004.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian and uterine periovulatory Doppler ultrasonography in bitches

et al. 2013

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Pesq. Vet. Bras. 33(9):1144-1150, setembro 2013 1144 RESUMO.-[Ultrassonografia Doppler ovariana e ute-rina em cadelas.] Este trabalho teve como objetivo des-crever as características ultrassonográficas uterinas e ova-rianas, e dopplervelocimétricas das suas artérias nos dias periovulatórios em cadelas. Quinze ciclos estrais em 10 ani-mais foram avaliados. As características ultrassonográficas, índices de resistência (IR) e índices de pulsatilidade (IP) do útero e dos ovários em cada animal foram registrados 5 dias antes e depois da ovulação (D0). Os dados foram anali-sados estatisticamente e os resultados foram expressos em média ± erro padrão da média (P<0,05). Como resultados as características ultrassonográficas uterinas foram seme-lhantes em todos os ciclos e dias avaliados, tendo o corpo uterino um diâmetro médio de 0,85±0,02cm. Foi observado um aumento no volume dos ovários e nos diâmetros dos folículos, tendo os ovários um volume de 0,64±0,06cm 3 , e a cavidade dos folículos um diâmetro de 0,46±0,01cm no dia da ovulação. Após a ovulação, foi observado colapso dos folículos somente em alguns ciclos. A perfusão sanguínea uterina diminuiu dois dias antes da ovulação e permane-ceu inalterada até a ovulação. Após a ovulação, houve um aumento gradual na perfusão das artérias uterinas e ova-rianas, direcionando o fluxo de sangue para os ovários e This paper aims to describe the uterine and ovarian ultrasonographic characteristics and Doppler velocimetric features of their arteries in bitches during the periovulatory period. Fifteen estrous cycles in 10 animals were evaluated. The ultrasonographic characteristics , resistance indices (RI) and pulsatility indices (PI) of the uterus and ovaries in each animal were recorded 5 days before and after ovulation (D0). The data were statistically analyzed, and the results were expressed as the mean ± standard error of mean (P<0.05). In results the ultrasonographic features of the uterus were the same on all of the cycles and evaluated days. The uterus had an average diameter of 0.85±0.02cm. An increase in the volume of the ovaries and the diameter of the ovarian follicles were measured. Ovaries had a volume of 0.64±0.06cm 3 , and the follicles cavities had a diameter of 0.46 ± 0.01 cm on the day of ovulation. After ovulation, it was observed that some follicles not collapse in some cycles. Two days prior to ovulation, the uterine blood perfusion decreased. This decrease remained unchanged until ovulation. Following ovulation, we measured a gradual increase in the uterine perfusion and in the ovarian artery. This artery directed blood flow to the ovaries and increased the intra-ovarian perfusion on the day after ovulation. In conclusion, specific features are observed in the uterus and ovarian ultrasound image and Doppler values of their arteries presented on the periovulatory days and when associated allow to estimate more accurately the date of ovulation. Pesq. Vet. Bras. 33(9):1144-1150, setembro 2013 1145 Ovarian and uterine periovulatory Doppler ultrasonography in bit...

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Ovarian and uterine periovulatory Doppler ultrasonography in bitches

et al. 2013

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“…Since 1970s, color Doppler ultrasonography has been used during the menstrual cycle as a non-invasive method to monitor uterine and ovarian blood flow [3][4][5][6]. With the constant change and development of Doppler ultrasound, and a widespread use of this technique, uterine and ovarian arteries as well as endometrial, sub-endometrial, ovarian artery and ovarian stromal blood flow changes during the menstrual cycle have been shown [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Comparison of uterine, endometrial and ovarian blood flow by transvaginal color Doppler ultrasound in ovulatory and anovulatory cycles

Doğan

Yıldız²,

Temizkan³

et al. 2016

Ginekol Pol

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Objectives: Blood flow to uterus and ovaries is demonstrated to be altered during mensturation. Studies has been published stating that blood flow differs also in ovulatory and anovulatory cycles. In this study, using color Doppler ultrasound, we aim to compare uterine, endometrial and ovarian blood flow during ovulatory and anovulatory cycles. Material and methods:Women volunteers who are aged between 18-40 had no endocrinological problem and not recieving exogenous hormone therapy were included to study. Blood levels of FSH, LH, E2, prolactine, DHEAS, free T4 were collected in early follicular phase. Uterina, subendometrial and intraovarian artery blood flow pulsatility and resistance indexes were analysed using Doppler USG technique. Patients were called out to control on 21st of cycle and progesterone levels were analysed. Patients who has ovulation signs in USG and progesterone level above 5 ng/mL were included to ovulatory cycle group. Patient who has no signs of ovulation in ultrasound and has not enough progesterone level were included to anovulatory cycle group.Results: LH and E2 levels were significantly higher in anovulatory patients. No correlation was found between endometrial blood flow resistance and basal E2, prolactine, testosterone levels. However, DHEAS levels were related to endometrial blood flow resistance in anovulatory cycles. No correlation was found between ovarian blood flow resistance/uterine blood flow resistance and basal E2, prolactine, testosterone, DHEAS levels. Conclusions:There is statistically significant difference between endometrial, ovarian, uterine artery blood flow resistance in ovulatory and anovulatory cycles. Blood flow resistance was found to be increased in anovulatory patients. Increased E2 levels in anovulatory cycles were related to endometrial linethickness and endometrial volume

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“…This vascular transformation is necessary to accommodate the huge increase in blood flow (3.5-fold) to the intervillous space required to successfully support the developing fetus. (Thaler et al, 1990;Ziegler et al, 1999).…”

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confidence: 99%

A Novel In Vitro Model of Trophoblast-Mediated Decidual Blood Vessel Remodeling

Dunk

Petković

Baczyk

et al. 2003

Laboratory Investigation

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SUMMARY:In vivo the extravillous trophoblasts (EVTs) penetrate the decidua and the first third of the myometrium to remodel the uterine spiral arteries and achieve the high-flow, low-resistance circulation characteristic of the intervillous space of the term placenta. Much of our understanding of these processes comes from histologic analysis of placental bed biopsies, a limited tissue source and one that can provide only a snapshot of a dynamic process. To better characterize these cellular interactions, we have developed an in vitro co-culture system in which first trimester villous explants are cultured at low oxygen tension in contact with 2-mm 2 sections of decidua parietalis from the same patient. Hematoxylin eosin counterstaining of paraffin sections shows that EVT columns form at the tips of the placental villi and adhere and penetrate the decidual surface. The decidual blood vessels in the path of the EVT show morphologic disruption. Immunohistochemical analysis of the co-cultures using both an endothelial specific anti-CD31 and an anti-smooth muscle actin antibody show a disruption of the integrity of the vessel lining together with a complete loss of organized smooth muscle actin surrounding the blood vessels. In contrast control decidua samples in the absence of placental villi exhibit blood vessels with a complete endothelial lining and an organized muscular sheath. Using both an anti-cytokeratin-7 and anti-Cdx-2 antibody specific to trophoblasts, we show that these changes coincide with invasion of the vessels by endovascular trophoblasts and penetration of the decidua by interstitial EVTs. No EVTs were found in the control decidua. Thus we conclude that this in vitro model mimics the physiologic change observed in vivo during trophoblast invasion into maternal decidual tissues, and as such it may provide useful information concerning the interactions between EVTs and decidual cells and vessels during early gestation. (Lab Invest 2003, 83:1821-1828.

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Regional Hemodynamic Adaptation During the Menstrual Cycle

Cited by 28 publications

References 18 publications

Ovarian and uterine periovulatory Doppler ultrasonography in bitches

Ovarian and uterine periovulatory Doppler ultrasonography in bitches

Comparison of uterine, endometrial and ovarian blood flow by transvaginal color Doppler ultrasound in ovulatory and anovulatory cycles

A Novel In Vitro Model of Trophoblast-Mediated Decidual Blood Vessel Remodeling

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