Regional variability in mottled subclinical melanoderma in the elderly

Petit, L.; Fogouang, L; Uhoda, Isabelle; Smitz, Simon; Piérard-Franchimont, C; Pierard, Gérald

doi:10.1016/s0531-5565(02)00200-0

Cited by 35 publications

(44 citation statements)

References 14 publications

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“…The presently described FMM was similar to the aspect of a regular bald scalp showing no evidence for chronic actinic damage (18,20). The typical speckled perifollicular FMM had been previously described (17).…”

Section: Discussionsupporting

confidence: 76%

“…They recalled rare sunburns on the scalp. The bald area and the forehead were scrutinized using the previously described ULEV method (17)(18)(19)(20).…”

Section: Methodsmentioning

confidence: 99%

“…UV light photography, in particular the UV light-enhanced visualization (ULEV) method (1,(17)(18)(19)(20), is a convenient means for highlighting early signs of this type of skin weathering.…”

Section: Introductionmentioning

confidence: 99%

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Epidermal field carcinogenesis in bald-headed: An attempt at finetuning early non-invasive detection

et al. 2009

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Abstract. Skin weathering and photoaging of the balding scalp have not attracted much investigative attention so far. However, the concept of field cancerization, in particular actinic field carcinogenesis, is likely applicable to this part of the body. The aim of the study was to finetune the epidermal actinic changes present on hairlessness scalp. The ultraviolet light-enhanced visualization (ULEV) method was used to assess a series of 50 healthy men older than 50 years with documented baldness for over 15 years. They were scrutenized looking for altered epidermal structures corresponding to photoaging-associated changes. Attention was focused on the faint mosaic melanoderma (FMM) and atypical scaliness. Observations were made on the scalp and forehead. FMM was recognized in each case. It presented either as a single manifestation of photoaging or it was associated with an unusual pattern of discrete rimmed scaliness. In this latter case histology and morphometry disclosed keratinocyte dysplasia. A similar scaly pattern was not seen on the forehead. Subtle skin surface changes were disclosed on long-standing sun-exposed balding scalps. The scaly aspect was distinct from dandruff, seborrheic dermatitis or any other common inflammatory scalp dermatosis. The presently described changes had not previously been described during early balding. It is suggested that the presently described condition may be associated with or indicative for actinic field carcinogenesis and incipient keratinocyte dysplasia.

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Section: Discussionsupporting

confidence: 76%

“…They recalled rare sunburns on the scalp. The bald area and the forehead were scrutinized using the previously described ULEV method (17)(18)(19)(20).…”

Section: Methodsmentioning

confidence: 99%

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Epidermal field carcinogenesis in bald-headed: An attempt at finetuning early non-invasive detection

et al. 2009

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“…The ultraviolet-light-enhanced visualization (ULEV) method [5, 6, 7, 8, 9, 10]is an improved variant of reflection ultraviolet photography [11, 12]. The procedure uses a computer-assisted CCD camera equipped with an internal UVA-emitting unit (Visioscan ® VC98, C + K Electronic, Cologne, Germany).…”

Section: Ultraviolet-light-enhanced Visualizationmentioning

confidence: 99%

The Conundrum of Skin Pores in Dermocosmetology

et al. 2005

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‘Skin pore’ is a term used by lay people and in the field of cosmetology. It remains misleading when it is not clearly defined. Indeed, lay people use it with at least 3 different meanings. Basically, invisible pores represent the openings of the sweat gland apparatus. By contrast, the visible pores represent enlarged empty funnel-shaped or cylindrical horny impacted openings of pilosebaceous follicles. This review describes some of the current objective methods used to describe skin pores.

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“…Repeated exposure to solar ultraviolet radiations induces skin aging signs such as deep wrinkles, loss of firmness and pigmentary changes [1][2][3][4]. These signs of chronological aging and photo-damage are associated with a general slow-down of cell renewal in the epidermis and loss of collagen synthesis in the dermis [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

Oddos¹,

Roure²,

Leyden³

et al. 2012

JCDSA

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Retinol is an ingredient used in cosmetic products for reducing the appearance of the signs of aging and photo-damage. Currently, most of these products contain 0.1% of retinol. However, at this concentration, some irritation can occur. We have evaluated in vitro and in a clinical study the potential efficacy of a combination of actives to improve the facial skin aging signs while using low concentration of retinol. We demonstrated, in vitro, that a chromone derivative, 5,7-di-hydroxy-2-methyl chromone (DMC), is able to enhance the collagen synthesis in culture of normal human dermal fibroblasts. The enhancement of retinol anti-wrinkle efficacy by DMC was confirmed in a small scale clinical trial. Specifically, a product associating low concentration of retinol (0.04%) and DMC (0.1%) in combination with low molecular weight hyaluronic acid fragments (50,000 Dalton of average molecular weight) has been applied topically for 8 weeks. Clinical results show significant improvement of various signs of facial skin aging such as wrinkles, pigmentary spots, tone unevenness, dullness and the overall photo-damage score. Improvements were still visible 4 weeks after the cessation of the test product application. This study demonstrates that significant lasting improvement of facial skin aging can be obtained with well tolerated low concentration of retinol when adequately formulated with other anti-aging ingredients.

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Regional variability in mottled subclinical melanoderma in the elderly

Cited by 35 publications

References 14 publications

Epidermal field carcinogenesis in bald-headed: An attempt at finetuning early non-invasive detection

Epidermal field carcinogenesis in bald-headed: An attempt at finetuning early non-invasive detection

The Conundrum of Skin Pores in Dermocosmetology

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

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