Regional variations in human milk oligosaccharides in Vietnam suggest FucTx activity besides FucT2 and FucT3

Leeuwen, Sander S. van; Stoutjesdijk, Eline; Kate, Geert A. ten; Schaafsma, Anne; Dijck-Brouwer, D.A. Janneke; Muskiet, Frits A. J.; Dijkhuizen, Lubbert

doi:10.1038/s41598-018-34882-x

Cited by 29 publications

(58 citation statements)

References 45 publications

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“…The composition of breast milk has been reported to differ between mothers in different countries and even between mothers in different locations in the same country. [49][50][51][52][53][54][55] Therefore, biochemical analysis of breast milk composition of Indian, Chinese, and Malay mothers could be helpful in understanding the variations in microbiota composition. However, due to the limitation of the current study of not having collected maternal stool samples, absence of breast milk composition and the availability of limited maternal dietary intake data, we cannot reflect much on this aspect.…”

Section: Discussionmentioning

confidence: 99%

Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets

Lawley

Wong

et al. 2020

Gut Microbes

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The human gut microbiota develops soon after birth and can acquire inter-individual variation upon exposure to intrinsic and environmental cues. However, inter-individual variation has not been comprehensively assessed in a multi-ethnic study. We studied a longitudinal birth cohort of 106 infants of three Asian ethnicities (Chinese, Malay, and Indian) that resided in the same geographical location (Singapore). Specific and temporal influences of ethnicity, mode of delivery, breastfeeding status, gestational age, birthweight, gender, and maternal education on the development of the gut microbiota in the first 2 years of life were studied. Mode of delivery, breastfeeding status, and ethnicity were identified as the main factors influencing the compositional development of the gut microbiota. Effects of delivery mode and breastfeeding status lasted until 6M and 3M, respectively, with the primary impact on the diversity and temporal colonization of the genera Bacteroides and Bifidobacterium. The effect of ethnicity was apparent at 3M post-birth, even before the introduction of weaning (complementary) foods, and remained significant after adjusting for delivery mode and breastfeeding status. Ethnic influences remained significant until 12M in the Indian and Chinese infants. The microbiota of Indian infants was characterized by higher abundances of Bifidobacterium and Lactobacillus, while Chinese infants had higher abundances of Bacteroides and Akkermansia. These findings provide a detailed insight into the specific and temporal influences of early life factors and ethnicity in the development of the human gut microbiota. Trial Registration: Clinicaltrials.gov registration no. NCT01174875.

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Section: Discussionmentioning

confidence: 99%

Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets

Lawley

Wong

et al. 2020

Gut Microbes

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“…The composition of breast milk has been reported to differ between mothers in different countries and even between mothers in different locations in the same country (49)(50)(51)(52)(53)(54)(55). Comparisons of HMO contents and other biochemical features of Indonesian and NZ breast milks have not been made, which may be a topic worth investigating further.…”

Section: Discussionmentioning

confidence: 99%

Fecal Microbiotas of Indonesian and New Zealand Children Differ in Complexity and Bifidobacterial Taxa during the First Year of Life

Lawley

Otal

Moloney-Geany

et al. 2019

Appl Environ Microbiol

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The biological succession that occurs during the first year of life in the gut of infants in Western countries is broadly predictable in terms of the increasing complexity of the composition of microbiotas. Less information is available about microbiotas in Asian countries, where environmental, nutritional, and cultural influences may differentially affect the composition and development of the microbial community. We compared the fecal microbiotas of Indonesian (n = 204) and New Zealand (NZ) (n = 74) infants 6 to 7 months and 12 months of age. Comparisons were made by analysis of 16S rRNA gene sequences and derivation of community diversity metrics, relative abundances of bacterial families, enterotypes, and cooccurrence correlation networks. Abundances of Bifidobacterium longum subsp. infantis and B. longum subsp. longum were determined by quantitative PCR. All observations supported the view that the Indonesian and NZ infant microbiotas developed in complexity over time, but the changes were much greater for NZ infants. B. longum subsp. infantis dominated the microbiotas of Indonesian children, whereas B. longum subsp. longum was dominant in NZ children. Network analysis showed that the niche model (in which trophic adaptation results in preferential colonization) of the assemblage of microbiotas was supported in Indonesian infants, whereas the neutral (stochastic) model was supported by the development of the microbiotas of NZ infants. The results of the study show that the development of the fecal microbiota is not the same for infants in all countries, and they point to the necessity of obtaining a better understanding of the factors that control the colonization of the gut in early life. IMPORTANCE This study addresses the microbiology of a natural ecosystem (the infant bowel) for children in a rural setting in Indonesia and in an urban environment in New Zealand. Analysis of DNA sequences generated from the microbial community (microbiota) in the feces of the infants during the first year of life showed marked differences in the composition and complexity of the bacterial collections. The differences were most likely due to differences in the prevalence and duration of breastfeeding of infants in the two countries. These kinds of studies are essential for developing concepts of microbial ecology related to the influence of nutrition and environment on the development of the gut microbiota and for determining the long-term effects of microbiological events in early life on human health and well-being.

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“…In general, milk group 1 seems to be the most common milk group, and milk group 4 is rare [35], however the distribution of milk groups in different populations varies depending on genetic background [36]. Based on the HMO composition of different milk samples, there is also evidence that further subgroups may exist [37,38].…”

Section: Introductionmentioning

confidence: 99%

Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants

et al. 2019

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Human milk oligosaccharides (HMOs) are a major component of human milk, and play an important role in protecting the infant from infections. Preterm infants are particularly vulnerable, but have improved outcomes if fed with human milk. This study aimed to determine if the HMO composition of preterm milk differed from that of term milk at equivalent stage of lactation and equivalent postmenstrual age. In all, 22 HMOs were analyzed in 500 samples of milk from 25 mothers breastfeeding very preterm infants (< 32 weeks of gestational age, < 1500 g of birthweight) and 28 mothers breastfeeding term infants. The concentrations of most HMOs were comparable at equivalent postpartum age. However, HMOs containing α-1,2-linked fucose were reduced in concentration in preterm milk during the first month of lactation. The concentrations of a number of sialylated oligosaccharides were also different in preterm milk, in particular 3′-sialyllactose concentrations were elevated. At equivalent postmenstrual age, the concentrations of a number of HMOs were significantly different in preterm compared to term milk. The largest differences manifest around 40 weeks of postmenstrual age, when the milk of term infants contains the highest concentrations of HMOs. The observed differences warrant further investigation in view of their potential clinical impact.

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Regional variations in human milk oligosaccharides in Vietnam suggest FucTx activity besides FucT2 and FucT3

Cited by 29 publications

References 45 publications

Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets

Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets

Fecal Microbiotas of Indonesian and New Zealand Children Differ in Complexity and Bifidobacterial Taxa during the First Year of Life

Human Milk Oligosaccharides in the Milk of Mothers Delivering Term versus Preterm Infants

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