Regional variations in mouse skin : Quantitation of epidermal compartments in two different body sites

The inner enamel epithelium (IEE) covers the labial tooth aspect as a one cell layer which, when cut sagittally, appears as a longitudinal cell column extending from the tooth origin toward the periphery. Following sudden tooth shortening, the IEE responds by an increased cell production which later declines below normal values. The perturbation affects all cell kinetic parameters; the progenitor compartment, which initially increases, diminishes in size toward end of the experiment. The cell cycle transition times, which initially decline, rise toward the end of the experiment. The mean normal daily cell production rate of 70 cell % (i.e. 70 cells are produced by 100 progenitors) increases to 111 cell % and then declines to a low of 51 cell %. The IEE response typifies the behavior of other cell renewal systems such as intestinal epithelium and epidermis.

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Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse

Mackenzie

Hill

1984

Cell Tissue Res.

117

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Epithelial-mesenchymal interactions play an important role during embryogenesis but it is uncertain whether such interactions influence the maintenance of epithelial structure in the adult. To examine this problem, separated epithelial and connective tissue components of skin and mucosae from various regions of adult mice were homo-or heterotypically recombined and transplanted to histo-compatible hosts. The patterns of tissue architecture and keratinization of the resultant epithelia were examined for changes indicative of mesenchymal influences on the epithelial phenotype. Each type of epithelium, in some recombinations, fully conserved its normal pattern of phenotypic expression indicating that subepithelial connective tissue from all regions is permissive and that regionally-specific connective tissue influences are not necessary for conservation of epithelial specificity. In other recombinations, however, the epithelium acquired features of tissue architecture or keratinization typical of the epithelium normally associated with the connective tissue component, indicating directive influences from the connective tissue. The patterns of epithelial response observed suggest that there may be separate connective tissue influences on epithelial architecture and cyto-differentiation and that there is a regionally-related variation in the competence of epithelia to respond to these influences.

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Regional variations in mouse skin : Quantitation of epidermal compartments in two different body sites

Cited by 24 publications

References 10 publications

Changes in Epidermal Cell Proliferation in Proliferative Skin Disease

Changes in Epidermal Cell Proliferation in Proliferative Skin Disease

The adaptation of a two-compartment cell renewal system to external demands

Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse

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