Regional variations in the levels of zinc, iron, copper, and calcium in the term human placenta

Manci, Elizabeth A.; Blackburn, Will R.

doi:10.1016/0143-4004(87)90078-6

Cited by 36 publications

(21 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are known regional variations in tissue sensitivity to polypeptides [19]; cytokine protein concentrations can vary up to 3-fold 85 across different sampling sites of the placenta [20] and expression of hypoxia-related genes, such as vascular endothelial growth factor, is lower near the basal plate close to the cord insertion site and higher at the peripheral chorionic plate [21]. Although the distribution of selenium within the placenta has not been examined, other elements such as iron and calcium, have been reported to be differentially distributed across the placental disc [22]. A single 90 study of GPx mitochondrial activity found this to be 41 per cent lower in the periphery compared to the pre-insertion region [23].…”

mentioning

confidence: 99%

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy

et al. 2010

View full text Add to dashboard Cite

A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. AbstractPreeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease. The selenoprotein glutathione peroxidases (GPxs) have critical roles in regulating antioxidant status. 30Objectives, study design and main outcome measures: Immunohistochemical measurements of GPx 1, GPx3 and GPx4 protein expression were performed on samples taken from three standardised sampling sites between the cord insertion and the periphery of the placenta from 12 normotensive, and 12 preeclamptic women to establish if their expression differed between sampling sites. Total GPx activities were also examined from the 35 three sampling sites of these placentae.Results: There were highly significant reductions in overall immunohistochemical staining of all 3 GPxs in the preeclampsia compared to normotensive placentae (GPx1: P = 0.016; GPx3: P = 0.003; GPx4: P < 0.001). Furthermore, graded differences in expression between the standardised placental sampling sites were also found for GPx3 (higher in the inner region, P 40 = 0.05) and GPx4 (higher in the periphery, P = 0.02) but not GPx1. Placental GPx enzyme activity was also significantly reduced in tissue from preeclamptic women as compared to normotensive women (P = 0.007; the difference was more pronounced nearest the cord insertion). Conclusions:We have shown highly significant reductions in expression of all three major 45 classes of GPx in placentae from women with preeclampsia, and distribution gradients in activity, which may relate to the differential oxygenation of regions of the placenta.

show abstract

mentioning

confidence: 99%

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy

et al. 2010

View full text Add to dashboard Cite

show abstract

“…This disagreement can be partially explained if we consider that the location of the placenta sampling site might influence tremendously the elemental concentration levels. While the concentrations for Fe, Cu and Zn do not differ significantly in the different locations, Ca concentrations can reach variations of the order of 50% [10]. However, this explanation is not valid for membrane, because in this work it was proved that the elemental concentration in this tissue is independent of the sampling site.…”

Section: Results and Conclusionmentioning

confidence: 77%

“…2 we present a diagram with the mean values and standard deviations for placenta, membrane and values from the literature [10].…”

Section: Results and Conclusionmentioning

confidence: 99%

“…Placenta is one of the most studied tissues [10,11,12]; however this kind of sample need to be collected at the delivery, thereby making any elemental concentration determination during pregnancy impossible. Moreover, careful selection and definition of the sampling site is essential in placenta analysis, because regional variations in placenta elemental composition are observed [10]. Placenta samples and amniotic fluid have also been studied for the child's weight and the mother's age dependence [13] Sample collection and preparation Placenta and membrane (the tissue connected to the placenta and involving the baby) samples, 35 of each, were collected at the delivery at Hospital Garcia de Orta in Portugal.…”

Section: Introductionmentioning

confidence: 99%

“…Protoninduced X-ray emission (PIXE) is one of the techniques used to study these organic fluids [9]. Placenta is one of the most studied tissues [10,11,12]; however this kind of sample need to be collected at the delivery, thereby making any elemental concentration determination during pregnancy impossible. Moreover, careful selection and definition of the sampling site is essential in placenta analysis, because regional variations in placenta elemental composition are observed [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Trace elements determination by energy dispersive X-ray fluorescence (EDXRF) in human placenta and membrane: a comparative study

Custódio

Carvalho²,

Nunes³

2003

Anal Bioanal Chem

View full text Add to dashboard Cite

This work is an application of energy dispersive X-ray fluorescence (EDXRF) as an analytical technique for trace elemental determination in human membrane and placenta and elemental concentrations correlations in both tissues. Whole samples were collected during the delivery from healthy mothers and full-term pregnancies. The age of the mother was between 25 and 40 years old, and the weight of the infants ranged from 2.56 to 4.05 kg. Samples were lyophilised and analysed without any chemical treatment. No significant differences in elemental content of placenta and membrane samples were observed except for Ca. Very low levels of Se, As and Pb were observed in all the analysed samples. Zn, considered as one of the key elements in newborn health, was not significantly different in the analysed samples, all of which originated from healthy mothers and healthy babies. The obtained values agree with the literature except for Ca, which is much higher in the studied samples.

show abstract

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Rani

Wadhwani

Chavan‐Gautam

et al. 2016

WIREs Developmental Biology

View full text Add to dashboard Cite

The placenta is an essential organ formed during pregnancy that mainly transfers nutrients from the mother to the fetus. Nutrients taken up by the placenta are required for its own growth and development and to optimize fetal growth. Hence, placental function is an important determinant of pregnancy outcome. Among various nutrients, fatty acids, especially long-chain polyunsaturated fatty acids (LCPUFAs), including omega 3 and omega 6 fatty acids, are essential for placental development from the time of implantation. Studies have associated these LCPUFAs with placental development through their roles in regulating oxidative stress, angiogenesis, and inflammation, which may in turn influence their transfer to the fetus. The placenta has a heterogeneous morphology with variable regional vasculature, oxidative stress, and LCPUFA levels in healthy pregnancies depending upon the location within the placenta. However, these regional structural and functional parameters are found to be disturbed in pathological conditions, such as preeclampsia (PE), thereby affecting pregnancy outcome. Hence, the alterations in LCPUFA metabolism and transport in different regions of the PE placenta as compared with normal placenta could potentially be contributing to the pathological features of PE. The regional variations in development and function of the placenta and its possible association with placental LCPUFA metabolism and transport in normal and PE pregnancies are discussed in this review. WIREs Dev Biol 2016, 5:582-597. doi: 10.1002/wdev.238 For further resources related to this article, please visit the WIREs website.

show abstract

Regional variations in the levels of zinc, iron, copper, and calcium in the term human placenta

Cited by 36 publications

References 7 publications

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy

Trace elements determination by energy dispersive X-ray fluorescence (EDXRF) in human placenta and membrane: a comparative study

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Contact Info

Product

Resources

About