Regional vascular density–visual field sensitivity relationship in glaucoma according to disease severity

Shin, Joong Won; Lee, Jiyun; Kwon, Junki; Choi, Jaewan; Kook, Michael S.

doi:10.1136/bjophthalmol-2017-310180

Cited by 98 publications

(79 citation statements)

References 21 publications

(15 reference statements)

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“…In the peripapillary area, the greatest differences in OCTA parameters between the normal and glaucoma groups were found in the infero- and superotemporal sectors [6, 18, 25, 35, 37, 42]. This was expected since these 2 sectors are the ones that are the most vulnerable to glaucomatous damage at an early stage [65, 66].…”

Section: Resultsmentioning

confidence: 87%

“…A significant correlation was found between the OCTA parameters and visual field MD, between OCTA parameters and glaucoma stage, and, as previously described, between the OCTA and OCT parameters in the peripapillary area [6, 17-20, 22-24, 26, 28-30, 33, 35, 36, 38, 39, 41, 45, 48, 50, 71-75], the optic disc [19, 23, 29, 36, 51-53, 57, 58], and the macular area [21, 36, 38, 61, 62, 64, 69, 75, 76]. As mentioned above, the results for the parafoveal area were not significant in some of the studies [38, 70].…”

Section: Resultsmentioning

confidence: 89%

“…Significantly lower OCTA parameters (vessel density, blood flow index, and flow index) were found in glaucoma eyes in comparison with normal eyes in the peripapillary area [6, 16-50], the optic disc [19, 23, 25, 32, 36, 51-60] and the whole image macular area [16, 21, 32, 34, 36-38, 61-64]. In all of those areas, the diagnostic abilities increased with increasing severity of glaucoma [32, 34, 52].…”

Section: Resultsmentioning

confidence: 99%

“…However, it requires a great amount of concentration and cooperation from the patient, lowering its repeatability and reproducibility. This is especially important in advanced glaucoma cases, with larger fluctuations in perimetric results, rendering it difficult to define actual glaucomatous progression [6]. However, visual field testing remains the preferred exam type in advanced glaucoma due to the nonexistence of the floor effect that exists in OCT.…”

Section: Introductionmentioning

confidence: 99%

“…Both technologies have strengths and limitations [2, 4, 5]. OCT is not dependent on patient response and therefore provides objective information on retinal layers’ thickness, with a high repeatability and reproducibility [6]. However, there is a floor effect for OCT in advanced glaucoma, when the OCT parameters reach a base level beyond which little change is seen with increasing severity of glaucoma [7].…”

Section: Introductionmentioning

confidence: 99%

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Optical Coherence Tomography Angiography in Glaucoma: A Review

et al. 2018

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Background: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking. Aims: To perform a literature review to assess the role of OCTA in glaucoma diagnosis and follow-up. Methods: A database search was carried out using MEDLINE, Embase, and Web of Science, including all original works registered until July 23, 2017. Results: OCTA (1) has a high repeatability and reproducibility, (2) has good discriminatory power to differentiate normal eyes from glaucoma eyes, (3) is more strongly correlated with visual function than conventional OCT, (4) has good discriminatory power to differentiate early-glaucoma eyes from normal eyes (i.e., at least equal to that of OCT), (5) reaches a floor effect at a more advanced disease stage than OCT, and (6) is able to detect progression in glaucoma eyes. Conclusion: OCTA shows potential to become a part of everyday glaucoma management.

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