Regionally Selective Atrophy After Traumatic Axonal Injury

Warner, Matthew A.; Youn, Teddy S.; Davis, Tommy; Chandra, Alvin; Plata, Carlos Marquez de la; Moore, Carol; Harper, Caryn R.; Madden, Christopher J.; Spence, Jeffrey S.; McColl, Roderick W; Devous, Michael D.; King, Richard; Diaz‐Arrastia, Ramon

doi:10.1001/archneurol.2010.149

Cited by 133 publications

(142 citation statements)

References 38 publications

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“…The applications did not provide the absolute volume nor provide voxelby-voxel analysis of data in the strict sense. Though our results were partly consistent with a previous report regarding absolute brain volume loss after TBI 12 and mostly consistent with the characteristics of longitudinal white matter atrophy after TBI detected by VBM analysis of SPM 1 as described above, they should be compared directly with findings using other powerful volumetric applications (e.g., FreeSurfer software) and VBM analysis (e.g., statistics of SPM itself ) in the future. Second, we excluded patients with cerebral contusion and epidural, subdural, or intracerebral hematoma to avoid the effects of abnormalities of parenchymal cortical reconstruction on the analytic process.…”

Section: Discussionsupporting

confidence: 92%

“…1 Moreover, our results were partly consistent with those of a previous study that investigated loss in absolute brain volume after DAI, 12 which demonstrated longitudinal and regional selective loss of volume in the middle anterior and middle posterior corpus callosum after DAI. 12 Unfortunately, the FreeSurfer program (http://surfer.nmr.mgh.harvard.edu) used in that study 12 mainly provides gray matter volume and cannot provide volumes of white matter tracts, except for the corpus callosum.…”

Section: Discussionsupporting

confidence: 90%

“…12 Unfortunately, the FreeSurfer program (http://surfer.nmr.mgh.harvard.edu) used in that study 12 mainly provides gray matter volume and cannot provide volumes of white matter tracts, except for the corpus callosum.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Regional White Matter Volume Reduction after Diffuse Axonal Injury using Voxel-based Morphometry

Uruma

Hashimoto

Abo

2015

MRMS

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Purpose: We developed a new and convenient method that employs voxel-based morphometry (VBM) to evaluate regional reduction in the volume of white matter after diffuse axonal injury (DAI).Methods: We studied 29 patients with moderate cognitive disability after DAI. Each subject underwent 3-dimensional volumetric magnetic resonance (MR) imaging. Images were preprocessed automatically using stand-alone software running on a Windows PC for VBM of volumetric MR imaging utilizing a statistical parametric mapping (SPM) version 8 software engine and an algorithm for diffeomorphic anatomic registration through exponentiated lie algebra (DARTEL). We then computed a Z-score for all coordinates on the white matter, which represented the relative reduction in white matter volume. Finally, we used voxel-based stereotactic extraction estimation (vbSEE) to compute the extent of regional reduction in the volume of white matter (rWMVR) for each region of interest (ROI), defined as the rate of coordinates with Z-scores exceeding 2.0 in the ROI. For each ROI, we used Pearson's correlation analysis to examine the correlation between the extent of regional volume reduction and patient scores on the Wechsler Adult Intelligence Scale III (WAIS-III).Results: We detected marked rWMVR in several ROIs, including the corpus callosum, and rWMVR correlated significantly with performance IQ and processing speed index in the splenium of the corpus callosum.Conclusions: The results indicate the utility of our applications for the daily clinical evaluation of DAI. That they can be used on a PC and allow acquisition of volumetric data from standard MR images are their advantages.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

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Evaluation of Regional White Matter Volume Reduction after Diffuse Axonal Injury using Voxel-based Morphometry

Uruma

Hashimoto

Abo

2015

MRMS

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“…33 These findings coincide with those of a number of studies that exhibited gross reductions in brain volume in various anatomical regions of the brain. 38,73,142 In a recent study, Strain et al correlated MRI FLAIR sequence, diffusion tensor imaging (DTI), and arterial spin labeling (ASL) findings with concussion history in a series of 28 retired National Football League (NFL) athletes, 8 of whom had mild cognitive impairment. The results of this study revealed that prior concussion resulting in loss of consciousness is a risk factor for development of mild cognitive impairment (defined as cognitive impairments beyond those expected for the age and education level of that individual) due to hippocampal atrophy, changes in cerebral blood flow, and white matter abnormalities.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Sports-related brain injuries: connecting pathology to diagnosis

Pan¹,

Connolly²,

Dangelmajer³

et al. 2016

FOC

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Neurosurg Focus 40 (4):E14, 2016M any sports-related brain injuries involve mild traumatic brain injuries (mTBIs), which result from physical blows to the head sustained over a period of time. Sports associated with an increased risk of head injury include American football, ice hockey, soccer, rugby, the martial arts, boxing, and bicycling. 21,90 These injuries are often unrecognized, undiagnosed, or underreported, which reflects the fact that this is a growing medical concern, often labeled a "silent epidemic." 8,66 Chronic exposure to mild brain injuries can result in long-term neurological consequences and represents a spectrum of disorders. The most remarkable outcome of mTBI is termed chronic traumatic encephalopathy (CTE), a clinical syndrome that is associated with neurodegeneration and behavioral, cognitive, and/or motor deficits. Although this disease has distinct pathological features, CTE is considered a diagnosis of exclusion because only postmortem biopsies can confirm the diagnosis. Therefore, new diagnostic methods need to be developed to: 1) inform patients of a definitive diagnosis, 2) better understand the epidemiology and risk factors of the disease, and 3) implement intervention programs to prevent any potential long-term complications. This review examines how understanding the pathology and molecular changes associated with repeated head trauma can lead to the discovery of novel imaging techniques and biomarkers. Mild Traumatic Brain Injury and CTEChronic traumatic encephalopathy has evolved from the so-called punch-drunk syndrome, which was used to describe a distinct neuropsychiatric condition that seemed to affect boxers, eventually becoming known as dementia pugilistica during the 1920s and 1930s. Symptoms such ABBrEvIATIoNs AD = Alzheimer's disease; APOE = apolipoprotein E; ASL = arterial spin labeling; BBB = blood-brain barrier; BOLD = blood oxygen level-dependent; CA = cornu ammonis; CTE = chronic traumatic encephalopathy; DTI = diffusion tensor imaging; FA = fractional anisotropy; fMRI = functional MRI; GFAP = glial fibrillary acidic protein; GRE = gradient recall echo; miRNA = microRNA; MRS = MR spectroscopy; mTBI = mild traumatic brain injury; NFL = National Football League; NFT = neurofibrillary tangle; NINDS = National Institute of Neurological Disorders and Stroke; NSE = neuron-specific enolase; p-tau = phosphorylated tau; SWI = susceptibility-weighted imaging; TDP-43 = TAR DNA-binding protein 43;18 F-FDDNP = 2-(1-{6- [(2-[fluorine-18] Brain injuries are becoming increasingly common in athletes and represent an important diagnostic challenge. Early detection and management of brain injuries in sports are of utmost importance in preventing chronic neurological and psychiatric decline. These types of injuries incurred during sports are referred to as mild traumatic brain injuries, which represent a heterogeneous spectrum of disease. The most dramatic manifestation of chronic mild traumatic brain injuries is termed chronic traumatic encephalopathy, which is associated with profo...

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“…Additionally, voxel-based, whole-surface based, and tensorbased analyses have also demonstrated significant global reductions in cortical thickness (Merkley et al, 2008) and cortical gray matter volume Ding et al, 2008;Gale et al, 2005;Warner et al, 2010a,b) as well as white matter volume (Ding et al, 2008;Sidaros et al, 2009;Vannorsdall et al, 2010). Late volumetric measures have demonstrated relation to measures of clinical severity Schonberger et al, 2009;Trivedi et al, 2007), outcome, (Ding et al, 2008;Gale and Prigatano, 2010;Warner et al, 2010b), cognition (Bergeson et al, 2004;Fujiwara et al, 2008;Himanen et al, 2005;Serra-Grabulosa et al, 2005;Tomaiuolo et al, 2004;Warner et al, 2010a), and potential for benefit from rehabilitation intervention (Strangman et al, 2010), although other studies have reported no correlation between volumetric measures and functional outcome (Anderson et al, 1995;Sherer et al, 2006;Yount et al, 2002).…”

Section: Mrimentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

116

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This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

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Regionally Selective Atrophy After Traumatic Axonal Injury

Cited by 133 publications

References 38 publications

Evaluation of Regional White Matter Volume Reduction after Diffuse Axonal Injury using Voxel-based Morphometry

Evaluation of Regional White Matter Volume Reduction after Diffuse Axonal Injury using Voxel-based Morphometry

Sports-related brain injuries: connecting pathology to diagnosis

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

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