Regioselective reaction: Synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

“…The most resistant bacteria to these compounds were Listeria monocytogenes, while the most susceptible bacteria were Bacillus cereus and Staphylococcus aureus. The obtained results are in agreement with Isloor et al, 26 who have synthesized 1,2,4-triazole-3(4H)-thione derivatives and reported higher antibacterial activity for the compounds with p-substitutions.…”

“…21 Many of them have shown strong antibacterial and antifungal activities, for example glycal-derived tetrahydrofuran 1,2,3-triazoles, 22 pyranoid derivatives comprising both triazole and conjugated carbonyl system, 23 d-glucose-derived benzyl and alkyl 1,2,3-triazoles, 24 6-triazolyl 2,3,6-trideoxy sugars, 25 and triazoles with substituted triazole-piperidine side chains. 26 Antitumor agents for chemotherapy also attract much attention, since cancer is responsible for many lethal outcomes worldwide. 27 Derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin have been obtained and their cytotoxicity toward human cancer cell lines HL-60, A-549, HeLa and HCT-8 were assessed, showing potent anticancer activity toward HL-60 and moderate cytotoxicities against the rest of the studied cell lines.…”

Design and Synthesis of New Bioactive 1,2,4-Triazoles, Potential Antitubercular and Antimicrobial Agents

“…Elemental analysis was undertaken with Elemental Vario EL III Carlo Erba 1108 analyser. Syntheses of the target compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were performed according to fig. 2, through following steps.…”

“…Triazole heterocycles is a building block of great value in drug candidates [8,9] and a large number of ring systems containing this heterocyclic core have been incorporated into a wide variety of therapeutically interesting drug compounds including antiinflammatory, CNS stimulants, sedatives, antianxiety [10,11] and antimycotic agents such as fluconazole, itraconazole and voriconazole [12,13] . The 1,2,4-triazole, as well found to exhibit antiasthmatic [14] , antiviral (ribavirin) [15] , antifungal (fluconazole) [16] , antimicrobial [17,18] , antibacterial [19][20][21] , insecticidal [22] , hypnotic [23] , cytotoxic [24] , antitubercular [25] and hypotensive [26,27] activities.…”

Crystal structure of dimethyl 5-(benzylamino)isophthalate, C17H17NO4

“…It is well known that carboxylates are excellent building blocks for the construction of coordination polymers because the carboxylate groups may induce core aggregation and link clusters into extended frameworks by its bridging ability [1][2][3][4][5][6][7]. The title compound was unintentionally synthesized during the recrystallisation of 5-(benzylamino)isophthalic acid from methanol.…”