Regioselective surface encoding of nanoparticles for programmable self-assembly

Chen, Gang; Gibson, Kyle J.; Liu, Di; Rees, Huw C.; Lee, Jung-Hoon; Xia, Weiwei; Lin, Ruoqian; Xin, Huolin L.; Gang, Oleg; Weizmann, Yossi

doi:10.1038/s41563-018-0231-1

Cited by 175 publications

(164 citation statements)

References 53 publications

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“…[ 9–16 ] The key influencing factor in the successful formation of directed diverse assemblies is the anisotropy of nanoscale building blocks originating from the shape and unequal distribution of ligands on the surface of nanocrystals. [ 17–21 ] Arrowhead gold nanorods (NRs), including two pyramidal heads connected by a four‐wing shaft, display high concave geometries and anisotropic properties. [ 22,23 ] Arrowhead gold NRs have been organized into 1D arrays (NR chains) [ 22 ] and supercrystals, [ 23 ] nevertheless, the fabrication of well‐defined directed assemblies with complicated concave geometries and concise motifs is challenging.…”

Section: Introductionmentioning

confidence: 99%

Directing Arrowhead Nanorod Dimers for MicroRNA In Situ Raman Detection in Living Cells

et al. 2020

Adv Funct Materials

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Directed self-assembled nanomaterials with biological applications have attracted great interest. Here, arrowhead gold nanorod (NR) dimers with side-by-side and end-to-end motifs (known as AHSBS and AHETE dimers, respectively) presented based on selective modification of arrowhead NRs with DNA and polyethylene glycol, possessing intense surface enhanced Raman scattering (SERS) signals, are assembled for in situ intracellular microRNA detection. The arrowhead NR dimers are capable of recognizing target microRNA in a sequence-specific manner as Raman signals significantly enhanced within dimers with both motifs. Following recognition, the dimers gradually disassemble, resulting in decreased SERS signals to achieve effective in situ Raman imaging and quantify the detection of target microRNA. The SERS intensity shows a linear relationship with intracellular target microRNA and a limit of detection of 0.011 amol ng RNA −1 for the AHETE dimer and 0.023 amol ng RNA −1 for the AHSBS dimer, respectively. The sensitivity for AHETE dimers is ≈2.1 times higher than that for AHSBS dimers, which is attributed to the small quantity of recognized molecules and stronger electrical enhancement, which causes greater SERS signals in the AHETE dimers. This approach opens up a new avenue for directed nanomaterials assembly and biological detection in living cells.

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Section: Introductionmentioning

confidence: 99%

Directing Arrowhead Nanorod Dimers for MicroRNA In Situ Raman Detection in Living Cells

et al. 2020

Adv Funct Materials

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“…Capping polymers with strong intra/intermolecular bonding interactions should be avoided because these forces increase the viscosity of the colloidal solution system and decrease the degree of freedom of NPs. Finally, an ideal capping polymer should possess a strong surface potential and as many unbonded terminal functional groups as possible to protect the NPs from aggregation and endow them with chemical affinity to target polymers [15,17,18]. Therefore, micromolecules and linear polymers are unsatisfactory candidates for the capping of metal NPs.…”

Section: Introductionmentioning

confidence: 99%

General Strategy to Prepare Single-Layered Ag–Au–Pt Nanocrystal Ternary-Coated Biomass Textiles through Polymer-Driven Self-Assembly

Gao

Feng

et al. 2020

Nanomaterials

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Current metal nanomaterials for developing nanofunctional textiles are mostly based on metal nanoparticles (NPs) that show aqueous instability, a tendency to aggregate, and low chemical affinity to biomass textiles, leading to low nano-metal uptake during finishing, significant declines in function, and nano-pollution. Herein, we demonstrate a strategy to transform metal (Ag, Au, and Pt) NPs into homogenous hyperbranched poly(amide-amine) (HBPAA)-encapsulated NPs showing high water solubility, oxidative resistance, and affinity to biomass materials upon surface capping with HBPAA. The proposed method represents a universal, simple, clean, and efficient self-assembly technology to produce monolayered Ag–Au–Pt ternary-coated biomass textiles. The combination of Ag, Au, and Pt NPs yields a positive potential of approximately +37.12 mV depending on the metal concentration and could simultaneously self-assemble onto natural fibers, including cotton, silk, and wool, through the one-step impregnation of textiles. Increasing the temperature and concentration of the mixture favors the self-assembly process. A mixture of 30–110 mg/L Ag, Au, and Pt NPs could nearly completely anchor onto cotton, silk, and wool textiles after impregnation at 100 °C for 1 h without chemical assistance, thereby indicating the possibility of clean production. As-prepared functional cotton, silk, and wool possessed similarly high antibacterial activities, and a mixture containing over 1500 mg/g NPs inhibited 99% of the Escherichia coli and Staphylococcus aureus in the sample textiles. The developed coating technology is simple, clean, controllable, and broadly applicable; thus, it could be potentially applied in functional textiles.

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“…Via this route, various kinds of clusters and large‐scale architectures have been successfully constructed by microscale patchy particles . However, directly installing patchy patterns onto nanoscale particle surface in designated locations is always challenging and only a few examples can be referred, which would attribute to the tiny superficial area of NPs . Indeed, a general and accurate approach is urgently needed to precisely encode functional parts onto the surface of NPs arbitrarily and with high fidelity.…”

Section: Introductionmentioning

confidence: 99%

Programmable Assembly of Nano‐architectures through Designing Anisotropic DNA Origami Patches

Wang

Dai

Duan³

et al. 2020

Angewandte Chemie

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Programmable assembly of nanoparticles (NPs) into well‐defined architectures has attracted attention because of tailored properties resulting from coupling effects. However, general and precise approaches to control binding modes between NPs remain a challenge owing to the difficulty in manipulating the accurate positions of the functional patches on the surface of NPs. Here, a strategy is developed to encage spherical NPs into pre‐designed octahedral DNA origami frames (DOFs) through DNA base‐pairings. The DOFs logically define the arrangements of functional patches in three dimensions, owing to the programmability of DNA hybridization, and thus control the binding modes of the caged nanoparticle with designed anisotropy. Applying the node‐and‐spacer approach that was widely used in crystal engineering to design coordination polymers, patchy NPs could be rationally designed with lower symmetry encoded to assemble a series of nano‐architectures with high‐order geometries.

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Regioselective surface encoding of nanoparticles for programmable self-assembly

Cited by 175 publications

References 53 publications

Directing Arrowhead Nanorod Dimers for MicroRNA In Situ Raman Detection in Living Cells

Directing Arrowhead Nanorod Dimers for MicroRNA In Situ Raman Detection in Living Cells

General Strategy to Prepare Single-Layered Ag–Au–Pt Nanocrystal Ternary-Coated Biomass Textiles through Polymer-Driven Self-Assembly

Programmable Assembly of Nano‐architectures through Designing Anisotropic DNA Origami Patches

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