Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives

Farag, Ahmad M.; Mayhoub, Abdelrahman S.; Barakat, Saber El-Sayed; Bayomi, Ashraf H.

doi:10.1016/j.bmc.2007.10.015

Cited by 126 publications

(58 citation statements)

References 24 publications

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“…The value of coupling constant is compatible with the E-configuration [24] depicted in Figure 2. Also its 13 C NMR spectrum showed two signals at δ 37.31 and 45.48 ppm assignable to -N(Me) 2 group [25], in addition to the signals of other carbon atoms.…”

Section: Resultsmentioning

confidence: 99%

Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives

Hassaneen¹,

Mohammed²

2011

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The reaction of 1-methylisoquinoline 1 with hydrazonoyl halides 2 in ethanol in the presence of chitosan under microwave irradiation affords triazoloisoquinoline 4. Product 4 reacts with dimethylformamide-dimethylacetal to give enaminones 7 which react with hydrazonoyl halides to give pyrazolyl triazoloisoquinoline 13. Also, 1-methylisoquinoline 1 reacts with arylisothiocyanate to give thioanilide 15 which reacts with hydrazonoyl halides to give the corresponding thiadiazolyl isoquinoline derivatives 20, 24.

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Section: Resultsmentioning

confidence: 99%

Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives

Hassaneen¹,

Mohammed²

2011

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“…These compounds have received attention in the field of current medicinal and pharmacological research, and are reported to have a broad spectrum of biological activities, such as antitumor, antimicrobial, antioxidant and antimalarial activities [67][68][69][70].…”

Section: The Pyrazole Functional Groupmentioning

confidence: 99%

Current Research on Antiepileptic Compounds

2015

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Epilepsy affects about 1% of the world's population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.

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“…In addition, a large number of thiophene derivatives have found to exhibit pharmacological activity [32][33][34] . Furthermore, diverse chemotherapeutic activities have ascribed to pyrazoles as antimicrobial [35][36] , antiparasitic 37 , antivirial 38 , and antineoplastic agents [39][40][41][42] . A detail literature survey indicates that benzothiazole ring system have a unique position in the designing and synthesis of novel biological active agents with remarkable analgesic and anti-inflammatory activities.The preliminary study of the structure-activity relationship reveals that electronic factors in benzothiazole ring has a great effect on a antimicrobial activity of these compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Some Benzothiazole Derivatives as Potential Antimicrobial Agent.

Awale¹

2016

IOSR

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Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives

Cited by 126 publications

References 24 publications

Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives

Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives

Current Research on Antiepileptic Compounds

Synthesis, Characterization and Biological Evaluation of Some Benzothiazole Derivatives as Potential Antimicrobial Agent.

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