Regioselective synthesis and theoretical studies of novel bis(tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-ones) catalyzed by ZnO nanoparticles

Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

“…Abd El‐Fatah et al developed a series of bis(tetrahydro[1,2,4]triazolo[5,1‐ b ]quinazolin‐8(4 H )‐ones) 118 via a three‐component reaction of bis‐aldehydes 14 or 16 with both 5‐amino‐1,2,4‐triazole 117 and dimedone 72 under conventional heating as well as under microwave irradiation in DMF in the presence of ZnO NPs as a heterogeneous catalyst (Scheme ).…”

Bis(enaminones) as Versatile Precursors for Novel Bis([1,2,4]triazolo[1,5‐a]pyrimidines) and Bis(2‐thioxo‐2,3‐dihydropyrido[2,3‐d]pyrimidin‐4(1H)‐ones)

“…In the last decades, our group has been heavily involved in a program aiming at exploring the synthetic potentiality of functionally substituted enamines . In continuation to this work, and in conjunction to our interest in the chemistry of bis(heterocycles) , we report herein on the reactivity patterns of enamines towards 1 H ‐1,2,4‐triazol‐5‐amine and 6‐amino‐2‐thioxopyrimidin‐4‐one.…”

“…Moreover, bis(heterocycles) have been reported to display wide range of bioactivities including antihypertensive , anticancer activities , and antiallergenic . 3‐Amino‐1,2,4‐triazole as a 1,3‐binucleophile is a versatile reagent in organic synthesis , and its reactions with electrophilic reagents offer a facile synthetic approach for diverse fused heterocycles containing azole moiety (cf. Fig.…”

Novel Bis(2‐cyanoketene‐S,S‐/S,N‐acetals): Versatile Precursors for Novel Bis(aminopyrazole) Derivatives

“…Motivated by these findings and in conjunction with our ongoing research work on bis(heterocycles) as well as poly(heterocycles) [37][38][39][40][41][42][43][44][45][46][47][48][49][50], we report herein on the synthesis of novel bis(substituted pyrazole) derivatives starting from novel bis(ketene-N,S-acetals).…”