2022
DOI: 10.1101/2022.04.05.22273474
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Regression discontinuity design to evaluate the effect of statins on myocardial infarction in electronic health records

Abstract: Background: Regression discontinuity is gaining popularity in epidemiologic studies aimed at causal inference from observational data, but there are limited real-world studies comparing this approach to potential outcomes methods. Methods: In this methodologic investigation, we estimate the causal effect of statins on myocardial infarction (MI), a positive control outcome, using regression discontinuity and propensity score matching. For the regression discontinuity analysis, we leveraged a 2008 UK guideline… Show more

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