Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

Abstract

Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma. Patients and Methods A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone. Conclusion A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.

Spontaneous regression of a posterior fossa meningioma: A case report

“…So far, 19 cases (male-female ratio 6:13) of spontaneous meningioma regression, including this case, have been reported [Table 1]. [3][4][5]7,8,10,11,13,19,[21][22][23][24][25] e average age was 54.7 (17-80) years at the time of tumor discovery, with a tendency to regress over several years. e sites of tumor development varied but appeared to be the same as in common meningiomas while only our case occurred in the posterior fossa.…”

Pregnancy and Childbirth in Women With Meningioma

“…This is likely due to a hyperhormonal state (increases in progesterone, human placental lactogen, and prolactin), as well as water retention and engorgement of vessels [1,[7][8][9]. Histopathology of these tumors has shown the expression of estrogen (ER+) and progesterone (PR+) receptors [10,11]. Meningiomas likewise have been shown to grow faster during the luteal phase of menstruation [8].…”