2022
DOI: 10.3389/fbioe.2022.885105
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Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy

Abstract: Acidosis and hypoxia of tumor remain a great challenge for cancer therapy. Herein, we developed Hb-LOX-DOX-ZIF8@platelet membrane nanoparticles (H-L-D-Z@PM NPs) to address this problem. Lactate oxidase (LOX) could deplete intratumoral lactate adequately and amplify oxidative stress efficiently. In the meantime, hemoglobin (Hb) was intended to deliver oxygen, relieve hypoxia, and boost the catalytic activity of LOX. The coated PM bestowed active tumor-targeting ability and good biocompatibility to these nanopar… Show more

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Cited by 12 publications
(10 citation statements)
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“…On the other hand, due to the severe hypoxia in TME and the fact that the LOX-related reaction is an oxygen-demanding process, researchers loaded haemoglobin (Hb) into ZIF-8 to deliver oxygen to alleviate the hypoxia in tumour tissues and to enhance the catalytic activity of LOX. 75 ZIF-8, a typical MOF, has been widely used in drug delivery for tumour therapy due to its excellent drug-carrying capacity and acid-sensitive properties. [85][86][87][88] However, the low stability of ZIF-8 in water and potential cytotoxicity limit its application.…”
Section: Zeolitic Imidazolate Framework (Zifs)mentioning
confidence: 99%
See 1 more Smart Citation
“…On the other hand, due to the severe hypoxia in TME and the fact that the LOX-related reaction is an oxygen-demanding process, researchers loaded haemoglobin (Hb) into ZIF-8 to deliver oxygen to alleviate the hypoxia in tumour tissues and to enhance the catalytic activity of LOX. 75 ZIF-8, a typical MOF, has been widely used in drug delivery for tumour therapy due to its excellent drug-carrying capacity and acid-sensitive properties. [85][86][87][88] However, the low stability of ZIF-8 in water and potential cytotoxicity limit its application.…”
Section: Zeolitic Imidazolate Framework (Zifs)mentioning
confidence: 99%
“…72 In recent years, a number of LOX delivery applications have used a variety of MOF materials. 34,[73][74][75][76] Table 2 summarises the LOXbased organic-inorganic hybrid nanocomposites used for tumour therapy.…”
Section: Lox-based Organic-inorganic Hybrid Nanocarriers For Tumour T...mentioning
confidence: 99%
“…For tumor acidosis and hypoxia localization, Luo et al utilized ZIF‐8 to develop Hb‐LOx‐DOX‐ZIF8@platelet membrane nanoparticles. [ 49 ] LOx sufficiently depleted intratumoral lactate and effectively amplified oxidative stress to make tumors more sensitive to doxorubicin (DOX)‐induced chemotherapy. Meanwhile, hemoglobin (Hb) transported O 2 , relieving hypoxia and enhancing the catalytic activity of LOx.…”
Section: Lox‐instructed Cancer Therapymentioning
confidence: 99%
“…[21,25,27,32,41,57,59,113,161] For example, Luo et al constructed Hb-LOX-DOX-ZIF8@platelet membrane nanosystem (HLDZ@PM NPs) using nano-ZIF-8 as the carrier. [162] LOX adequately depleted intratumoral lactate, making tumor cells more sensitive to DOX-induced chemotherapy.…”
Section: Combining Lactate Metabolic Regulation With Chemotherapymentioning
confidence: 99%