2019
DOI: 10.1007/s40484-018-0162-5
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Regulation by competition: a hidden layer of gene regulatory network

Abstract: Background: Molecular competition brings about trade-offs of shared limited resources among the cellular components, and thus introduces a hidden layer of regulatory mechanism by connecting components even without direct physical interactions. Several molecular competition scenarios have been observed recently, but there is still a lack of systematic quantitative understanding to reveal the essence of molecular competition. Methods: Here, by abstracting the analogous competition mechanism behind diverse molecu… Show more

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Cited by 25 publications
(32 citation statements)
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“…LA is very convenient for the measurement of dynamic correlation. However, according to the results reported by Wei (Wei et al, 2019), the ceRNA strength forms a sharp peak around the most optimal microRNA concentration, indicating very large deviation of correlation. In this study, we used LA as a characteristic of ceRNA regulation.…”
Section: Parameters (Supplementarymentioning
confidence: 69%
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“…LA is very convenient for the measurement of dynamic correlation. However, according to the results reported by Wei (Wei et al, 2019), the ceRNA strength forms a sharp peak around the most optimal microRNA concentration, indicating very large deviation of correlation. In this study, we used LA as a characteristic of ceRNA regulation.…”
Section: Parameters (Supplementarymentioning
confidence: 69%
“…Besides studying ceRNAs using sequencing data, researchers also proposed mathematical models to simulate the ceRNA process, such as the minimal model (Figliuzzi et al, 2013), mass-action model (Ala et al, 2013), and coarse-grained model (Yuan et al, 2015). Recently, Wei et al constructed a unified coarse-grained competition motif model and uncovered the complexity and generality of the molecular competition effect, including the ceRNA model (Wei et al, 2019). In that study, the investigators proposed that the strength of competition between ceRNAs is influenced by the abundance of ceRNAs and their target microRNAs (Wei et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
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“…For instance, the initiation and translation rates of different transcripts are effectively coupled by the competition for the ribosome pool, so that modifications of a given RNA species can alter the translational dynamics of other RNAs [13]. Quite generally, competition for limited and shared molecular resources induces effective interactions between the competing species, with signs (positive or negative) that depend on the specifics of the underlying processes [14]. While such interactions constitute in principle an additional layer of indirect regulation, their intensity is strongly context-dependent [9].…”
Section: Introductionmentioning
confidence: 99%