Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi

Kuo, Yur‐Ren; Meng, Hsiang Chen; Tsai, Wei‐Jern

doi:10.1007/s000110050727

Cited by 121 publications

(69 citation statements)

References 39 publications

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“…Emodin isolated from a great deal of herbs is an effective constituent with many effects [3][4][5] . It was reported that emodin could inhibit the expression of α-smooth muscle actin (α-SMA) and reduce the transformation and synthesis of TGF-β1 [6] .…”

Section: Discussionmentioning

confidence: 99%

“…Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) isolated from a g reat deal of herbs is an effective constituent with many effects. Lots of pharmaceutical studies have demonstrated that emodin has many biological effects [3][4][5] , such as anticancer, antimicrobial, and antiinflammatory effects, etc. Moreover, several studies [6,7] have revealed that emodin is efficacious in the management of acute pancreatitis and hepato-cirrhosis, but studies on chronic pancreatitis are rare.…”

Section: Introductionmentioning

confidence: 99%

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Effect of emodin on pancreatic fibrosis in rats

Wang

Gao²,

Yu³

et al. 2007

WJG

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AIM:To establish the rats model of chronic fibrosing pancreatitis and to prove the anti-fibrotic effect of emodin in chronic pancreatitis with fibrosis. METHODS:Fifty rats were randomly divided into five groups, 10 rats in each group. Trinitrobenzene sulfonic acid (TNBS) was infused into the pancreatic duct to induce chronic pancreatitis in rats (except for normal group). Emodin-treated rats were fed with different doses of emodin (20, 40 and 80 mg/kg body weight) for 28 d, while normal group and control group received 0.9% sodium chloride solution. Serum levels of hyaluronic acid (HA) and laminin (LN) were determined by radioimmunoassay. Histopathological alterations were studied by optical microscopy. Expression of collagen was also examined while transforming growth factorbeta-1 (TGF-β1) was localized by immunochemistry. RESULTS:In emodin-treated rats, the serum levels of HA and LN were decreased significantly (HA, 62.2 ± 19.3 µg/L vs 112.7 ± 26.5 µg/L, P < 0.05; LN 44.3 ± 10.4 µg/L vs 86.2 ± 16.5 µg/L, P < 0.05); the degree of fibrosis was ameliorated observably; the expression of collagen in pancreatic tissue was reduced especially in high-dose emodin-treated group (36% ± 5% vs 42% ± 6%, P < 0.05); with the increased doses of emodin, the expression of TGF-β1 was declined, compared with those in control group. CONCLUSION:Emodin has an anti-fibrotic effect on pancreatic fibrosis in rats. Because of its anti-fibrotic effect, it could be a potential herb for the treatment of chronic pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of emodin on pancreatic fibrosis in rats

Wang

Gao²,

Yu³

et al. 2007

WJG

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“…Rheum undulatum L. (Polygonaceae, RU), a well known Chinese medicine, is a perennial herb that is distributed and cultivated mainly in South Korea (9). The rhizome of the species is one of the important herbal medicines that are used widely as laxatives, anti-inflammatories and anti-blood stagnation agents in East Asia (10,11). Recently, it was found that RU and 3 compounds isolated from it (desoxyrhapontigenin, emodine, and chrysophanol) showed significant antidiabetic activity based on the oral glucose tolerance test (9).…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition

Lee¹,

Yoon²,

Hwang³

et al. 2012

BMB Reports

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Protein tyrosine phosphatase 1B (PTP1B) is important in the regulation of metabolic diseases and has emerged as a promising signaling target. Previously, we reported the PTP1B inhibitory activity of Rheum undulatum (RU). In the present study, we investigated the metabolic regulatory effects of RU in a high-fat diet (HFD) model. RU treatment significantly blocked body weight gain, which was accompanied by a reduction of feed efficiency. In addition, it led to a reduction of liver weight mediated by overexpression of PPARα and CPT1 in the liver, and an increase in the expression of adiponectin, aP2, and UCP3 in adipose tissue responsible for the reduction of total and LDL-cholesterol levels. Chrysophanol and physcion from RU significantly inhibited PTP1B activity and strongly enhanced insulin sensitivity. Altogether, our findings strongly suggest that 2 compounds are novel PTP1B inhibitors and might be considered as anti-obesity agents that are effective for suppressing body weight gain and improving lipid homeostasis. [BMB reports 2012; 45(3): 141-146]

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“…Emodin is the main active component of Da Huang. Previous studies demonstrated that emodin affects bacteriostasis, catharsis, relieves Oddi sphincter spasm, inhibits abnormal metabolism of vasoactive substances (e.g., eicosenoic acid), improves the microcirculation and antagonizes coagulation and thrombus formation (25,29,30). The present study demonstrated that emodin significantly increases MФ ICAM-3 protein expression in rats with SAP/SIRS (P<0.05), thereby promoting the interaction between ICAM-3 and CD14, enhancing identification and phagocytotic capacity of pMФs and relieving inflammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

In vitro effects of emodin on peritoneal macrophage intercellular adhesion molecule-3 in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome

Zhang

Sun

et al. 2013

Biomedical Reports

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Abstract. Rhubarb is often used in Chinese herbal medicine for the treatment of systemic inflammatory response syndrome (SIRS). Emodin is the main active constituent of rhubarb. This study was performed to investigate the in vitro effects of emodin and dexamethasone on peritoneal macrophage (pMΦ) phagocytosis and the expression of intercellular adhesion molecule-3 (ICAM-3). A total of 40 Sprague-Dawley (SD) rats were randomly divided into sham surgery (n=10) and model groups (n=30). After 24 h, pMΦs were harvested and the model group was randomly divided into three subgroups (n=10 rats̸subgroup): the 5 µg/ml emodin, 0.1 µmol/ml dexamethasone and control groups. The drugs were administered following macrophage (MΦ) adhesion for 24 h. pMΦ phagocytosis was significantly increased in the emodin group compared to that in the control group. Moreover, pMΦ phagocytosis was significantly increased in the emodin group compared to that in the dexamethasone group. The expression of ICAM-3 was significantly increased in the emodin group compared to that in the control group. The expression of ICAM-3 was significantly increased in the emodin group compared to that in the dexamethasone group. The expression of ICAM-3 was significantly increased in the emodin and dexamethasone groups compared to that in the control group. pMΦ phagocytosis and ICAM-3 expression were significantly increased following emodin treatment compared to those in the control and dexamethasone groups, indicating that emodin may enhance pMΦ phagocytosis and apoptotic cell clearance by altering ICAM-3 expression.

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Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi

Abstract: We hypothesize that the inhibitory mechanisms of emodin on activated T cells proliferation are related to the impairment of cytokine production, IL-2 mRNA level and [Ca2+]i in the cells.

Cited by 121 publications

References 39 publications

Effect of emodin on pancreatic fibrosis in rats

Effect of emodin on pancreatic fibrosis in rats

Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition

In vitro effects of emodin on peritoneal macrophage intercellular adhesion molecule-3 in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome

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