Regulation of EphB1 expression by dopamine signaling

Halladay, Alycia; Yue, Yong; Michna, Laura; Widmer, David A.J.; Wagner, George C.; Zhou, Ran

doi:10.1016/s0169-328x(00)00249-7

Cited by 25 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with this hypothesis, earlier studies revealed that dopaminergic neuron innervation coming from the substantia nigra leads to increased striatal expression of the EphB1 receptor (Halladay et al, 2000). Similarly, it is clear that, as in any other system, there must be genes and mechanisms other than ephrin/Eph genes involved in this process, which would include other types of cues, acting locally or from the afferents from the cortex and substantia nigra.…”

Section: Intrinsic and Extrinsic Mechanisms Of Striatal Compartmentalmentioning

confidence: 69%

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum

et al. 2008

View full text Add to dashboard Cite

*Brain structures, whether mature or developing, display a wide diversity of pattern and shape, such as layers, nuclei or segments. The striatum in the mammalian forebrain displays a unique mosaic organization (subdivided into two morphologically and functionally defined neuronal compartments: the matrix and the striosomes) that underlies important functional features of the basal ganglia. Matrix and striosome neurons are generated sequentially during embryonic development, and segregate from each other to form a mosaic of distinct compartments. However, the molecular mechanisms that underlie this time-dependent process of neuronal segregation remain largely unknown. Using a novel organotypic assay, we identified ephrin/Eph family members as guidance cues that regulate matrix/striosome compartmentalization. We found that EphA4 and its ephrin ligands displayed specific temporal patterns of expression and function that play a significant role in the spatial segregation of matrix and striosome neurons. Analysis of the striatal patterning in ephrin A5/EphA4 mutant mice further revealed the requirement of EphA4 signalling for the proper sorting of matrix and striosome neuronal populations in vivo. These data constitute the first identification of genes involved in striatal compartmentalization, and reveal a novel mechanism by which the temporal control of guidance cues enables neuronal segregation, and thereby the generation of complex cellular patterns in the brain.

show abstract

Section: Intrinsic and Extrinsic Mechanisms Of Striatal Compartmentalmentioning

confidence: 69%

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Preliminary investigations in our lab, based on differential display with semaphorin-targeted primers, identified several axon guidance molecules as suitable candidates involved in drug-induced neuroadaptations (Widmer, 2000). Based on these findings a microarray was designed, containing 39 guidance cues together with 10 positive and 10 negative control genes (Table 1), with a view of evaluating expression changes in four different brain regions under various paradigms of drug treatment (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless little is known about cell surface molecules involved in neuroadaptations after drug intake. Strong induction of a surface tetraspanin protein, CD81, has been described (Michna et al, 2001, Halladay et al, 2000, Brenz-Verca et al, 2001, Bahi et al, 2004. Also specific axon guidance cues, such as EphB1 and ephrin-B2, are expressed after challenges with psychomotor stimulants, (Zhou, 1998;Yue et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Cocaine-induced expression changes of axon guidance molecules in the adult rat brain

Bahí

Dreyer

2005

Molecular and Cellular Neuroscience

View full text Add to dashboard Cite

Administration of drugs of abuse induces strong molecular adaptations and plasticity within the mesolimbic dopamine (DA) system, a pathway essential for reward-seeking behavior. Little is known about the specific targets involved in this neuroadaptation process, but there are indications that cocaine and other drugs of abuse share the ability to alter the morphology of neuronal dendrites and spines, the primary site of excitatory synapses in the brain. Axon guidance molecules, the very molecular cues that regulate the formation of axon-target connections during development, may mediate these alterations. To test this hypothesis, we investigated mRNA expression changes of 39 axon guidance molecules, including 17 Semaphorins, 12 Ephs, 8 Ephrins and 2 neuropilins in the mesolimbic dopamine system of cocaine-treated animals under different paradigms by mean of DNA-Microarray and quantitative real-time PCR. In all cases, strong changes in gene expression are observed, yielding to up or down-regulation of these axon guidance molecules. Our data suggest that cocaine treatment induces activation of a complex program of synaptic rearrangements, which may partly recapitulate the plastic changes occurring during development, and may underlie the important neuroplastic adaptations that occur in the reward-and memory-related brain centers following drug action. We conclude that in some brain regions, exposure to psychomotor-stimulant drugs produce expression changes in axon guidance molecules, which may contribute to cognitive deficits associated with drug abuse.2

show abstract

“…We focused on striatal slices because of the established role for the ephrinB2/EphB1 system in the development of the nigro-striatal pathway and in drug-induced striatal plasticity (Yue et al, 1999;Halladay et al, 2000). EphrinB2 activated by clustered EphB1/Fc increased the potency of mGlu receptor agonists in enhancing PI hydrolysis in striatal slices, suggesting an increased ligand affinity at mGlu receptors or an increased efficiency of receptor signaling.…”

Section: Discussionmentioning

confidence: 99%

Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons

Calò¹,

Bruno²,

Spinsanti³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

We examined the interaction between ephrins and metabotropic glutamate (mGlu) receptors in the developing brain and cultured neurons. EphrinB2 coimmunoprecipitated with mGlu1a receptors, in all of the brain regions examined, and with mGlu5 receptors in the corpus striatum. In striatal slices, activation of ephrinB2 by a clustered form of its target receptor, EphB1, amplified the mGlu receptormediated stimulation of polyphosphoinositide (PI) hydrolysis. This effect was abolished in slices treated with mGlu1 or NMDA receptor antagonists but was not affected by pharmacological blockade of mGlu5 receptors. An interaction among ephrinB2, mGlu1 receptor, and NMDA was supported by the following observations: (1) the NR1 subunit of NMDA receptors coimmunoprecipitated with mGlu1a receptors and ephrinB2 in striatal lysates; (2) clustered EphB1 amplified excitatory amino acid-stimulated PI hydrolysis in cultured granule cells grown under conditions that favored the expression of mGlu1a receptors; and (3) clustered EphB1 amplified the enhancing effect of mGlu receptor agonists on NMDA toxicity in cortical cultures, and its action was sensitive to mGlu1 receptor antagonists. Finally, fluorescence resonance energy transfer and coclustering analysis in human embryonic kidney 293 cells excluded a physical interaction between ephrinB2 and mGlu1a (or mGlu5 receptors). A functional interaction between ephrinB and mGlu1 receptors, which likely involves adaptor or scaffolding proteins, might have an important role in the regulation of developmental plasticity.

show abstract

Regulation of EphB1 expression by dopamine signaling

Cited by 25 publications

References 33 publications

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum

Cocaine-induced expression changes of axon guidance molecules in the adult rat brain

Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons

Contact Info

Product

Resources

About