Regulation of Ion Channel Function by Gas Molecules

Shah, Nikhil; Liu, Zhou

doi:10.1007/978-981-16-4254-8_8

Cited by 3 publications

(2 citation statements)

References 224 publications

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“…To investigate the effects of NO on cellular behavior, human embryonic kidney (HEK) 293T cells are selected in which DNA fragments are transferred by human adenovirus type 5. Transient receptor potential vanilloid family membrane 1 (TRPV1) , is chosen for the characterization of NO-mediated signal transduction, since it has been demonstrated to mediate NO-induced nociception in peripheral nervous system of mouse response to NO stimulation. , The calcium indicator GCaMP6s plasmid is cotransfected to observe NO associated response . As illustrated in Figure a, when TRPV1 on the cell membrane is stimulated by NO, calcium channels are simultaneously opened, and extracellular calcium ions flow into the cell and combine with the indicator, resulting in changes in intracellular fluorescence intensity .…”

Section: Resultsmentioning

confidence: 99%

“…54,55 The calcium indicator GCaMP6s plasmid is cotransfected to observe NO associated response. 56 As illustrated in Figure 5a, when TRPV1 on the cell membrane is stimulated by NO, calcium channels are simultaneously opened, and extracellular calcium ions flow into the cell and combine with the indicator, resulting in changes in intracellular fluorescence intensity. 49 The improved influx of calcium ions is observed after adding NO donor DEA NONOate (10 mM) as shown in Figure 5b, demonstrating that HEK 293T cells are successfully transfected with TRPV1 and the GCaMP6s plasmids.…”

Section: Resultsmentioning

confidence: 99%

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Fully Biodegradable and Long-Term Operational Primary Zinc Batteries as Power Sources for Electronic Medicine

Huang

Hou

et al. 2023

ACS Nano

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Given the advantages of high energy density and easy deployment, biodegradable primary battery systems remain as a promising power source to achieve bioresorbable electronic medicine, eliminating secondary surgeries for device retrieval. However, currently available biobatteries are constrained by operational lifetime, biocompatibility, and biodegradability, limiting potential therapeutic outcomes as temporary implants. Herein, we propose a fully biodegradable primary zinc−molybdenum (Zn−Mo) battery with a prolonged functional lifetime of up to 19 days and desirable energy capacity and output voltage compared with reported primary Zn biobatteries. The Zn−Mo battery system is shown to have excellent biocompatibility and biodegradability and can significantly promote Schwann cell proliferation and the axonal growth of dorsal root ganglia. The biodegradable battery module with 4 Zn−Mo cells in series using gelatin electrolyte accomplishes electrochemical generation of signaling molecules (nitric oxide, NO) that can modulate the behavior of the cellular network, with efficacy comparable with that of conventional power sources. This work sheds light on materials strategies and fabrication schemes to develop highperformance biodegradable primary batteries to achieve a fully bioresorbable electronic platform for innovative medical treatments that could be beneficial for health care.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fully Biodegradable and Long-Term Operational Primary Zinc Batteries as Power Sources for Electronic Medicine

Huang

Hou

et al. 2023

ACS Nano

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Advances in nanotherapeutics for tumor treatment by targeting calcium overload

Wang,

Peng,

Xiao

et al. 2025

Colloids and Surfaces B: Biointerfaces

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G protein Inactivation as a Mechanism for Addiction Treatment

Neiswanger,

Ruiz,

Kimball

et al. 2024

Preprint

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The endogenous dynorphin/kappa opioid receptor (KOR) system in the brain mediates the dysphoric effects of stress, and KOR antagonists may have therapeutic potential for the treatment of drug addiction, depression, and psychosis. One class of KOR antagonists, the long-acting norBNI-like antagonists, have been suggested to act by causing KOR inactivation through a cJun-kinase mechanism rather than by competitive inhibition. In this study, we screened for other opioid ligands that might produce norBNI-like KOR inactivation and found that nalfurafine (a G-biased KOR agonist) and nalmefene (a KOR partial agonist) also produce long-lasting KOR inactivation. Neither nalfurafine nor nalmefene are completely selective KOR ligands, but KOR inactivation was observed at doses 10-100 fold lower than necessary for mu opioid receptor actions. Daily microdosing with nalfurafine or nalmefene blocked KORs responsible for antinociceptive effects, blocked KORs mediating stress-induced aversion, and mitigated the aversion during acute and protracted withdrawal in fentanyl-dependent mice. Both nalfurafine and nalmefene have long histories of safety and use in humans and could potentially be repurposed for the treatment of dynorphin-mediated stress disorders.

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Regulation of Ion Channel Function by Gas Molecules

Cited by 3 publications

References 224 publications

Fully Biodegradable and Long-Term Operational Primary Zinc Batteries as Power Sources for Electronic Medicine

Fully Biodegradable and Long-Term Operational Primary Zinc Batteries as Power Sources for Electronic Medicine

Advances in nanotherapeutics for tumor treatment by targeting calcium overload

G protein Inactivation as a Mechanism for Addiction Treatment

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