2021
DOI: 10.1016/j.pbiomolbio.2021.06.008
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Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

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Cited by 24 publications
(9 citation statements)
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References 236 publications
(310 reference statements)
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“…It was identifiable by being node‐like in appearance, by being relatively rich in collagen and by a low expression of cardiac troponin I (Figure 11d ). In addition, Hcn4 which is a key marker of the conduction system (Boyett et al, 2021 ), was expressed in a subset of the myocardium with a low expression of troponin I (Figure 11d ) which is another characteristic of conduction tissue (Sizarov et al, 2011 ). This presumed sinus node was small, approximately 100 μm wide and 500 μm dorso‐ventrally long in all three investigated specimens.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…It was identifiable by being node‐like in appearance, by being relatively rich in collagen and by a low expression of cardiac troponin I (Figure 11d ). In addition, Hcn4 which is a key marker of the conduction system (Boyett et al, 2021 ), was expressed in a subset of the myocardium with a low expression of troponin I (Figure 11d ) which is another characteristic of conduction tissue (Sizarov et al, 2011 ). This presumed sinus node was small, approximately 100 μm wide and 500 μm dorso‐ventrally long in all three investigated specimens.…”
Section: Resultsmentioning
confidence: 99%
“…Given the extremely high heart rates of shrews, one could presume an unusual cardiac conduction system. The cardiac conduction system has been identified on the basis of histological characters such as weak stain and richness in collagen (Davies, 1942 ; Ho et al, 2003 ) and on the presence of the funny current channel, Hcn4 (Boyett et al, 2021 ; Sizarov et al, 2011 ). We show in the shrew the presence of myocardium that is insulated by collagen and that expresses Hcn4 where a mammal sinus node and His bundle would be expected.…”
Section: Discussionmentioning
confidence: 99%
“…Given the numerous mechanisms that interact to produce SA nodal pacemaking at the cellular level [ 49 , 50 ], it was not especially surprising that heterogeneity in ionic current properties caused a percentage of cells to cease beating spontaneously. Although it seems reasonable to ask whether this behavior is realistic or an artifact of the modeling, recent studies strongly suggest that dormant cells do indeed exist, both in isolated cell studies and within intact SA nodal tissue.…”
Section: Discussionmentioning
confidence: 99%
“…In the sinus node, evidence suggests dysfunction and downregulation of I f in HF [9,10,162,163] which may cause bradyarrhythmia in certain situations. In contrast, in the ventricle, I f is upregulated (Figure 9) [164][165][166] which was attributed to enhanced mRNA and protein expressions of HNC2 and HCN4 channels in the failing human ventricle [167].…”
Section: Changes Of the Pacemaker Current (I F ) In Hfmentioning
confidence: 99%