Regulation pattern of fish irf4 (the gene encoding IFN regulatory factor 4) by STAT6, c-Rel and IRF4

Li, Shun; Guo, Xia; Lu, Long-Feng; Lu, Xiaobing; Wu, Nan; Zhang, Yong-An

doi:10.1016/j.dci.2015.02.018

Cited by 19 publications

(13 citation statements)

References 42 publications

(44 reference statements)

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“…For example, IL-4-induced activation of STAT6 and the STAT6 target gene GATA3 are both required for T H 9 differentiation, although GATA3 is more important for T H 2 differentiation [13, 46]. Upon activation, phosphorylated STAT6 facilitates the transcription of GATA3 and IRF4 [47]. However, modest retrovirus transduction-induced expression of IRF4 and/or GATA3 did not rescue IL-9 secretion in STAT6-deficient CD4 + T cells, indicating that additional factors are required for the STAT6-dependent transcriptional modulation of T H 9 differentiation [46].…”

Section: Th9 Cell Differentiation and Signal Transductionmentioning

confidence: 99%

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

Zhang

et al. 2016

Oncotarget

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Naïve CD4+T cells differentiate into various T cell subsets depending on the specific cytokine environment. TH9 cells are less well-characterized than other T cell subsets, and factors that control their development and function have only recently been identified. It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammatory bowel diseases, and cancer. Thus, the promotion or suppression of TH9 cell differentiation, transcriptional control and function may provide novel treatments for clinical inflammation, autoimmune diseases and tumors.

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Section: Th9 Cell Differentiation and Signal Transductionmentioning

confidence: 99%

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

Zhang

et al. 2016

Oncotarget

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“…20 D. rerio cell lines have been developed (Xing et al ., ) and six of them were commercially available, ZF4, PA C2, ZEM2, ZFL, AB.9 and SJD.1 (ATCC; http://www.atcc.com). Only ZF4 cells, which were cytogenetically heteroploid, had been reported to be susceptible to NNV and SVCV (Chen et al ., ; Li et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…An ideal D. rerio in vitro cell system, however, susceptible to various fish viruses and effective in exogenous gene expression, has not been available, although c. 20 D. rerio cell lines have been developed (Xing et al, 2009) and six of them were commercially available, ZF4, PA C2, ZEM2, ZFL, AB.9 and SJD.1 (ATCC; www.atcc.com). Only ZF4 cells, which were cytogenetically heteroploid, had been reported to be susceptible to NNV and SVCV (Chen et al, 2015;Li et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Establishment of a cell line with high transfection efficiency from zebrafish Danio rerio embryos and its susceptibility to fish viruses

Jin

Chen

et al. 2017

Journal of Fish Biology

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A cell line ZBE3 isolated from a continuous cell culture derived from zebrafish Danio rerio blastomeres by clonal growth was characterized. ZBE3 cells had been subcultured for >120 passages since the initial primary culture of the blastomeres. The ZBE3 cells grow stably at temperature from 20 to 32° C with an optimum temperature of 28° C in ESM2 or ESM4 medium with 15% foetal bovine serum (FBS). The optimum FBS concentration for ZBE3 cell growth ranged from 15 to 20%. Cytogenetical analysis indicated that the modal chromosome number of ZBE3 cells was 50, the same as the diploid chromosome number of D. rerio. Significant cytopathic effect was observed in ZBE3 cells after infection with redspotted grouper nervous necrosis virus, Singapore grouper iridovirus and grass carp reovirus, and the viral replication in the cells was confirmed by real-time quantitative PCR and transmission electron microscopy, indicating the susceptibility of ZBE3 cells to the three fish viruses. After transfected with pEGFP-N3 plasmid, ZBE3 cells showed a transfection efficiency of about 40% which was indicated by the percentage of cells expressing green fluorescence protein. The stable growth, susceptibility to fish viruses as well as high transfection efficiency make ZBE3 cells be a useful tool in transgenic manipulation, fish virus-host cell interaction and immune response in fish.

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“…Therefore, many studies focus on this molecule or other molecules influencing the production of IFN. The immunological investigations mentioned in this review have been dedicated to innate and adaptive immunity using classical transcription analyses [40][41][42][43][44]48,55,76,77,[80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96], gnotobiotic (germ-free) [81] and transgenic fish lines for functional studies [89,91,[97][98][99], but also visualization of the behaviour of professional phagocytes [100].…”

Section: Immunologymentioning

confidence: 99%

Zebrafish as a Model for Fish Diseases in Aquaculture

Jørgensen

2020

Pathogens

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The use of zebrafish as a model for human conditions is widely recognized. Within the last couple of decades, the zebrafish has furthermore increasingly been utilized as a model for diseases in aquacultured fish species. The unique tools available in zebrafish present advantages compared to other animal models and unprecedented in vivo imaging and the use of transgenic zebrafish lines have contributed with novel knowledge to this field. In this review, investigations conducted in zebrafish on economically important diseases in aquacultured fish species are included. Studies are summarized on bacterial, viral and parasitic diseases and described in relation to prophylactic approaches, immunology and infection biology. Considerable attention has been assigned to innate and adaptive immunological responses. Finally, advantages and drawbacks of using the zebrafish as a model for aquacultured fish species are discussed.

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Regulation pattern of fish irf4 (the gene encoding IFN regulatory factor 4) by STAT6, c-Rel and IRF4

Cited by 19 publications

References 42 publications

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

Establishment of a cell line with high transfection efficiency from zebrafish Danio rerio embryos and its susceptibility to fish viruses

Zebrafish as a Model for Fish Diseases in Aquaculture

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