Regulatory interplay between microRNAs and WNT pathway in glioma

Tabnak, Peyman; Mafakheri, Asrin; Emsailpoor, Zanyar Haji; Kazemi, Tohid; Shekari, Najibeh

doi:10.1016/j.biopha.2021.112187

Cited by 22 publications

(8 citation statements)

References 145 publications

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“…There have been quite a number of miRNAs reported to modulate integral components of the Wnt signaling pathway, therefore, contributing to the pathogenesis of various cancers (Tabnak et al, 2021). Of these, miR-3648 is one of many human specific miRNAs identified and is of particular interest due to its minimum off-targeting (Hu et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Involvement of miR-3648 mediated APC2 1 dysregulation in early onset and breast cancer progression

Batool

Qadir²,

Shan³

et al. 2022

KJS publishes peer-review articles in Mathematics, Computer Sci

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Multiple cancers arise due to aberrations in the Wnt signaling pathway. Several miRNAs modulate the integral components of the wingless integrated (Wnt) signaling pathway. miR-3648 is a human-specific miRNAs that is of particular interest due to its minimal off-targeting effect. In this study, we investigated the expression of miR-3648 and APC2 in breast cancer patients of Pakistan. Correlations of miR-3648 and APC2 expression with clinico-pathological features and breast cancer subtypes were observed in tissue samples by means of quantitative real time PCR. Our results showed that miR-3648 was relatively downregulated in Luminal A subtype, with corresponding upregulation of APC2 in these patients. Moreover, the transcript levels of both miR-3648 and APC2 were found to be inversely regulated in breast cancer women presented with early disease onset, pre-menopause, low tumor grade, early clinical stage, absence of nodal invasion and metastasis, further suggesting the molecular interplay of these molecules in breast cancer development and progression.

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Section: Discussionmentioning

confidence: 99%

Involvement of miR-3648 mediated APC2 1 dysregulation in early onset and breast cancer progression

Batool

Qadir²,

Shan³

et al. 2022

KJS publishes peer-review articles in Mathematics, Computer Sci

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“…Wnt pathway is an evolutionary conserved pathway required for embryonic differentiation and development, and recent studies frequently addressed the consequences of its dysregulation in glioma tumorigenesis. The Canonical Wnt pathway is also referred to as the Wnt/β-Catenin pathway since it leads to the accumulation of β-Catenin in the nucleus affecting a crucial transcription factor named TCF4 responsible for Wnt target genes expression [ 54 ]. A study by Zhang et al turned out FoxM1 acts as a downstream for canonical Wnt pathway in glioma and is required for β-catenin activation by its translocating to the nucleus, leading to self-renewal and tumorgenicity of GBM-initiating cells (GICs) [ 55 ].…”

Section: Foxm1mentioning

confidence: 99%

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics

Tabnak,

Hasanzade Bashkandi,

Ebrahimnezhad

et al. 2023

Cancer Cell Int

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Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas, oligodendrogliomas, glioblastoma multiforme (GBM), and mixed tumors. The forkhead box (FOX) transcription factors comprise a collection of proteins that play various roles in numerous complex molecular cascades and have been discovered to be differentially expressed in distinct glioma subtypes. FOXM1 and FOXOs have been recognized as crucial transcription factors in tumor cells, including glioma cells. Accumulating data indicates that FOXM1 acts as an oncogene in various types of cancers, and a significant part of studies has investigated its function in glioma. Although recent studies considered FOXO subgroups as tumor suppressors, there are pieces of evidence that they may have an oncogenic role. This review will discuss the subtle functions of FOXOs and FOXM1 in gliomas, dissecting their regulatory network with other proteins, microRNAs and their role in glioma progression, including stem cell differentiation and therapy resistance/sensitivity, alongside highlighting recent pharmacological progress for modulating their expression.

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“…They also confirmed that high mobility group A2 (HMGA2), a target gene of let‐7 g‐5p, is expressed at lower levels when VB is administered and exerts inhibitory effects on Wnt/β‐catenin and protein kinase C (PKC) signaling pathways. Recently, the mediatory role of miRNAs in dysregulation of the Wnt/β‐catenin pathway has been highlighted as one of the main contributors to the exacerbation of glioma malignancy (Tabnak, Mafakheri, Emsailpoor, Kazemi, & Shekari, 2021). As a result, developing antiglioma drugs with a natural basis can be considered a proper strategy against glioma through selectively inhibiting the Wnt/β‐catenin pathway.…”

Section: Natural Products and Mirnas In Glioma Therapymentioning

confidence: 99%

“…Recently, the mediatory role of miRNAs in dysregulation of the Wnt/βcatenin pathway has been highlighted as one of the main contributors to the exacerbation of glioma malignancy (Tabnak, Mafakheri, Emsailpoor, Kazemi, & Shekari, 2021). As a result, developing antiglioma drugs with a natural basis can be considered a proper strategy against glioma through selectively inhibiting the Wnt/β-catenin pathway.…”

Section: Verbascosidementioning

confidence: 99%

Natural products in suppressing glioma progression: A focus on the role of microRNAs

Tabnak

Masrouri

Mafakheri

2022

Phytotherapy Research

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Glioma is one of the most common malignancies of the central nervous system. Due to inadequate response to the current treatments available, glioma has been at the center of recent cancer studies searching for novel treatment strategies. This has prompted an intensive search using linkage studies and preliminary evidence to gain efficient insight into the mechanisms involved in the alleviation of the pathogenesis of glioma mediated by miRNAs, a group of noncoding RNAs that affect gene expression posttranscriptionally. Dysregulated expression of miRNAs can exacerbate the malignant features of tumor cells in glioma and other cancers. Natural products can exert anticancer effects on glioma cells by stimulating the expression levels of tumor suppressor miRNAs and repressing the expression levels of oncogenic miRNAs. In this review, we aimed to collect and analyze the literature addressing the roles of natural products in the treatment of glioma, with an emphasis on their involvement in the regulation of miRNAs.

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Regulatory interplay between microRNAs and WNT pathway in glioma

Cited by 22 publications

References 145 publications

Involvement of miR-3648 mediated APC2 1 dysregulation in early onset and breast cancer progression

Involvement of miR-3648 mediated APC2 1 dysregulation in early onset and breast cancer progression

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics

Natural products in suppressing glioma progression: A focus on the role of microRNAs

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