Regulatory Mechanisms between Quorum Sensing and Virulence in Salmonella

Abstract

Salmonella is a foodborne pathogen that causes enterogastritis among humans, livestock and poultry, and it not only causes huge economic losses for the feed industry but also endangers public health around the world. However, the prevention and treatment of Salmonella infection has remained poorly developed because of its antibiotic resistance. Bacterial quorum sensing (QS) system is an intercellular cell–cell communication mechanism involving multiple cellular processes, especially bacterial virulence, such as biofilm formation, motility, adherence, and invasion. Therefore, blocking the QS system may be a new strategy for Salmonella infection independent of antibiotic treatment. Here, we have reviewed the central role of the QS system in virulence regulation of Salmonella and summarized the most recent advances about quorum quenching (QQ) in virulence attenuation during Salmonella infection. Unraveling the complex relationship between QS and bacterial virulence may provide new insight into the therapy of pathogen infection.

Virulence Gene Properties and Phylogenetic Relationship of Salmonella Serotypes Isolated from Different Sources in North of Iran

“…Additionally, the Salmonella plasmid virulence (spv) operon, which is important for the intracellular survival and replication of Salmonella and contributes to the systemic phase of the illness (20), was studied. Furthermore, the sefA and pefA genes related to fimbriae production (21), hilA and sdiA genes related to transcriptional regulation involved in the regulation of pathogenicity and quorum sensing (22), and the iroB gene that encodes an enzyme involved in the biosynthesis of salmochelins, siderophores that facilitate the acquisition of iron by the bacteria from the host (23) were analyzed.…”

Transcriptional Profiling of the Effect of Coleus amboinicus L. Essential Oil against Salmonella Typhimurium Biofilm Formation

“…Strong evidence suggests that QS plays a critical role in bacterial biofilm formation [10]. QS serves as an intercellular communication system that enables bacteria to coordinate their population density and regulate a diverse range of physiological processes [13].…”

Nanosystems as Quorum Quenchers Targeting Foodborne Pathogens: Understanding the Inhibition Mechanisms and Their Docking Predictions

“…The use of quorum quenchers has been an attractive approach to inhibit the virulence and biofilm formation of bacteria, without killing them, thus reducing the risk of resistance development. There are different types of QQs, such as enzymatic and non-enzymatic, based on different mechanisms of action: Genes associated with quorum sensing in Gram-positive and negative bacteria [11,12]. (AHLs) or peptides, the most common QS molecules, into inactive forms that cannot activate the QS machinery.…”