Regulatory non-coding RNAs in nervous system development and disease

Abstract

Introduction 3. Regulation of nervous system development by long non-coding RNAs 3.1. LncRNAs are involved in neural differentiation 3.2. LncRNAs are involved in synaptogenesis and synaptic plasticity 4. Functional involvement of long non-coding RNAs in neurological diseases 4.1. Alzheimer's disease (AD) 4.2. Parkinson's disease (PD) 4.2.1. Malat1 inhibits alpha-synuclein protein degradation and antagonizes miR-124 4.2.2. HOTAIR enhances both LRRK2 mRNA stability and caspase-3 activity 4.2.3. MAPT-AS1 reduces MAPT expression in an epigenetic manner 4.2.4. Roles of PINK1, Parkin, and NEAT1 in neuronal degeneration via disruption of mitochondrial homeostasis 4.3. Glioma 4.3.1. Major signaling pathways regulated by miRNAs and lncRNAs for glioma initiation and progression 4.3.2. Roles of signaling pathways related to cancer hallmarks 4.3.3. miRNAs and lncRNAs that modulate sustained proliferative signaling 4.3.4. miRNAs and lncRNAs that modulate the activation of invasion and metastasis 4.3.5. miRNAs and lncRNAs that modulate resistance to cell death 4.3.6. Possible mechanisms for dysregulation of lncRNA expression in glioma development 5. Perspectives 6. Acknowledgements 7. References

Long Noncoding RNA SNHG1 Knockdown Ameliorates Apoptosis, Oxidative Stress and Inflammation in Models of Parkinson’s Disease by Inhibiting the miR-125b-5p/MAPK1 Axis

“…MicroRNAs are believed to play important roles via serving as the targets of lncRNAs thereby to regulate target genes expression and implicate in PD pathogenesis. 11,21,22 miR-135b exerts a protective role in MPP-intoxicated PD cell model by inhibition of apoptosis and neuroinflammation by sponging FoxO1 23 or GSK3. 24 Meanwhile, BDNF-AS knockdown could increase SH-SY5Y cell viability, block autophagy and apoptosis in MPTP-induced PD models via miR-125b-5p.…”

Transcriptome Sequencing of CeRNA Network Constructing in Status Epilepticus Mice Treated by Low-Frequency Repetitive Transcranial Magnetic Stimulation

“…It is currently known that lncRNA is involved in nervous system development, synapse occurrence, and synaptic plasticity. The disorder of lncRNA may cause neurological diseases such as epilepsy, Parkinson’s disease (PD), and Alzheimer’s disease (AD) (Yamada 2019 ). LncRNA and miRNA are probably related to specific biological processes in epilepsy, including ion/gated channels and GABA receptors (Gross and Tiwari 2018 ; Haenisch et al 2016 ).…”

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

“…Regulatory non-coding RNAs (ncRNAs) have also been explored for therapeutic application due to their ability to regulate oxidative stress and modulate the expression of proteins involved in the pathogenesis of NDDs (Oe et al 2019). Apart from ncRNAs, miRNAs have also been implemented as therapeutic agents against chronic, life-threatening diseases, namely cancer, stroke, NDDs, and diabetes (Behl et al 2020).…”