Regulatory roles of OASL in lung cancer cell sensitivity to Actinidia chinensis Planch root extract (acRoots)

Lv, Jiapei; Wang, Lingyan; Shen, Hui; Wang, Xiangdong

doi:10.1007/s10565-018-9422-4

Cited by 27 publications

(18 citation statements)

References 21 publications

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“…OASL has been reported to exert antiviral as well as proviral function, depending on various mechanisms and phase of infection [33]. Lv et al recently reported that inhibition of OASL in lung-cancer-derived cells inhibits their proliferation [51]. However, the mechanism causative for the pro-proliferative effect of OASL still has to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

RNA Binding Proteins as Drivers and Therapeutic Target Candidates in Pancreatic Ductal Adenocarcinoma

Glaß

Michl

Hüttelmaier

2020

IJMS

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Pancreatic ductal adenocarcinomas (PDAC) belong to the most frequent and most deadly malignancies in the western world. Mutations in KRAS and TP53 along with some other frequent polymorphisms occur almost universally and are likely to be responsible for tumor initiation. However, these mutations cannot explain the heterogeneity in therapeutic responses observed in PDAC patients, which limits efficiency of current therapeutic strategies. Instead, recent classifications of PDAC tumor samples are based on transcriptomics data and thus include information about epigenetic, transcriptomic, and post-transcriptomic deregulations. RNA binding proteins (RBPs) are important post-transcriptional regulators involved in every aspect of the RNA life cycle and thus considerably influence the transcriptome. In this study, we systematically investigated deregulated expression, prognostic value, and essentiality reported for RBPs in PDAC or PDAC cancer models using publicly available data. We identified 44 RBPs with suggested oncogenic potential. These include various proteins, e.g., IGF2 mRNA binding proteins (IGF2BPs), with reported tumor-promoting roles. We further characterized these RBPs and found common patterns regarding their expression, interaction, and regulation by microRNAs. These analyses suggest four prime candidate oncogenic RBPs with partially validated target potential: APOBEC1, IGF2BP1 and 3, and OASL.

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Section: Discussionmentioning

confidence: 99%

RNA Binding Proteins as Drivers and Therapeutic Target Candidates in Pancreatic Ductal Adenocarcinoma

Glaß

Michl

Hüttelmaier

2020

IJMS

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“…Phosphoinositide 3-kinase (PI3K) is a family of related intracellular signal transducer enzymes to phosphorylate the 3-position hydroxyl group of the inositol ring of phosphatidylinositol, perform cellular functions (e.g. cell growth, proliferation, differentiation, and survival), and regulate cell responses to drug therapy [24]. Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase to regulate the addition of phosphate molecules onto serine and threonine amino acid residues, carry out biological function (e.g.…”

Section: Discussionmentioning

confidence: 99%

Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

Song

et al. 2019

J Transl Med

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Background Telocytes play key roles in maintenance of organ/tissue function and prevention of organ injury. However, there are great challenges to investigate telocytes functions using primary telocytes, due to the difficulties of isolation, identification, and stability. The present study aims at constructing continuous cell strain of mouse lung telocyte cell line with stable characters by gene modification and investigating biological behaviors and responses of gene-modified telocytes to inflammation. Methods Mouse primary lung telocytes were isolated and identified using immune-labeling markers and immunoelectron microscopy. Primary telocytes were transformed with Simian vacuolating virus 40 small and large T antigen (SV40). Biological characters, behaviors morphology, and proliferation of those gene-modified telocytes were defined and monitored dynamically for 50 generations, as compared with primary lung telocytes. Cell cycle of mouse primary lung telocytes or gene-modified telocytes was detected by flow cytometry. Results Gene modified telocytes of generations 5, 10, 30 and 50 were observed with telopodes and also showed CD34 and ckit positive. Multiple cellular morphology were also observed on telocyte cell-line under monitor of celliq and enhanced cell proliferation were showed. SV40 transduction was also reduced apoptosis and increased the ratio of S and G2 phases in telocyte cell-line. Conclusion We successfully constructed mouse lung telocyte cell-line which maintained the biological properties and behaviors as primary telocytes and could responses to inflammation induced by LPS. Thus, gene-modified lung telocytes, Telocyte Line, would provide a cell tool for researchers exploring the roles and applications of telocytes involved in physiological and pathological states in future. Electronic supplementary material The online version of this article (10.1186/s12967-019-1870-y) contains supplementary material, which is available to authorized users.

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“…Crude extracts, fractions, and isolated compounds from A. chinensis exhibited strong inhibition against tumor growth in various forms of human cancer cells. These cancer cells were hepatocellular carcinoma cells HepG2 (Xu et al, 2010; Zuo et al, 2012), Hep3B, SMMC7721, MHCC97L, MHCC97H, HCCLM3 (Fang et al, 2019), HL-7702 (He et al, 2017), Huh7 (Hou et al, 2018), lung cancer cells NCI-H460 and NCI-H1299 (Lv et al, 2018), colon cancer cells HT-29, LoVo, and SW480, pharyngeal carcinoma cell lines Fadu and HEP-2, gastric cancer cells SGC-7901, BGC-823, MKN-49P, and MFC, as well as other cancer cells like A549, P-388, MCF-7, SK-OV-3, and HeLa (Chang and Case, 2005; Xu et al, 2010; Xu et al, 2010; Zuo et al, 2012; Shen et al, 2014; Xia et al, 2017; Gu et al, 2017; Wang et al, 2017; Wei et al, 2018). These reported antitumor activities are consistent with the traditional usage such as liver cancer, lung cancer, colon cancer, esophagus cancer, and gastric cancer.…”

Section: Chemical Compositionmentioning

confidence: 99%

Actinidia chinensis Planch.: A Review of Chemistry and Pharmacology

Fang

Chen

et al. 2019

Front. Pharmacol.

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Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or additive in food products and as folk medicine in China. It is a good source of triterpenoids, polyphenols, vitamin C, carbohydrate, amino acid, and minerals. These constituents render the A. chinensis with a wide range of pharmacological properties including antitumor, antioxidant, anti-inflammatory, immunoregulatory, hypolipemic, antidiabetic, and cardiovascular protective activities, suggesting that it may possibly be value in the prevention and treatment of pathologies associated to cancer, oxidative stress, and aging. This minireview provides a brief knowledge about the recent advances in chemistry, biological activities, utilization, and storage of Chinese kiwifruit. Future research directions on how to better use of this crop are suggested.

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Regulatory roles of OASL in lung cancer cell sensitivity to Actinidia chinensis Planch root extract (acRoots)

Cited by 27 publications

References 21 publications

RNA Binding Proteins as Drivers and Therapeutic Target Candidates in Pancreatic Ductal Adenocarcinoma

RNA Binding Proteins as Drivers and Therapeutic Target Candidates in Pancreatic Ductal Adenocarcinoma

Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

Actinidia chinensis Planch.: A Review of Chemistry and Pharmacology

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