Regulatory synthesis and characterization of hydroxyapatite nanocrystals by a microwave-assisted hydrothermal method

Chen, Jia; Liu, Jiawei; Deng, Haishan; Yao, Shuang; Wang, Youfa

doi:10.1016/j.ceramint.2019.09.203

Cited by 42 publications

(27 citation statements)

References 44 publications

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“…The specific surface area and the total pore volume are large for both products. Similar values of these parameters were obtained using both synthetic calcium source precursors and related natural resources, however, with higher energy inputs and more complicated synthesis processes (Akram et al, 2015;Chen et al, 2020;Yudin et al, 2019). The contribution of micropores in the entire pore volume is small hence it can be concluded that the materials exhibit a mesoporous nature of the structure what is desired for those used as industry adsorbents.…”

Section: The Impact Of Temperature and Phsupporting

confidence: 58%

Microwave assistant synthesis of calcium phosphate minerals using hen’s eggshells as a calcium source

Kalbarczyk¹,

Szcześ²

2020

Physicochem. Probl. Miner. Process.

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In this study raw hen's eggshells were used as a calcium source for calcium phosphate mineral synthesis. The materials composed of brushite and different amounts of HA (hydroxyapatite) and β-TCP (β-tricalcium phosphate) with the needle-like, sheet-like and hexagonal structures were synthesized in the presence of the microwave. It was found that the time of microwave action, temperature and initial pH are parameters affecting the morphology and composition of the obtained materials, i.e. the increasing duration of MW exposure increases the amount of HA increases, whereas the temperature increase causes an increase in the contents of brushite and β-TCP. The lowering of initial pH leads to an increase in the brushite content.

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Section: The Impact Of Temperature and Phsupporting

confidence: 58%

Microwave assistant synthesis of calcium phosphate minerals using hen’s eggshells as a calcium source

Kalbarczyk¹,

Szcześ²

2020

Physicochem. Probl. Miner. Process.

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“…Each of the abovementioned methods induces different morphologies of micro- and nano-size HA particles: rods [ 51 , 52 ], sheets [ 53 ], spheres [ 54 ], wires [ 55 ], fibers [ 56 ], flower, worm, hexagonal prism, platelet, lath, strip, dandelion, chrysanthemum, rosette, or spheres [ 20 ]. Among those, the hydrothermal method generates conditions for high crystallinity and stoichiometric hydroxyapatite synthesis (Ca/P ratio around 1.67) from shells of calcium carbonate precursor, usually with a rod-like morphology and hexagonal unit cell symmetry [ 57 , 58 ]. Moreover, combining hydrothermal synthesis (HT) with microwave thermal treatment (MW) was observed to lead to a higher crystal size of HA from egg-shells after only 1–36 min for MW-HT, compared to several hours when using HT alone; a higher pH (between 9–11) and reaction time generate a high content of carbonate groups in the resulting HA lattice [ 53 , 59 , 60 , 61 ], but the high pressure in the synthesis system ensures a high internal and external porosity, as has been reported only in few papers [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

“…Besides, a wide range of morphologies were obtained only using the two combined techniques for nano-hydroxyapatite synthesis. Furthermore, the association between the two techniques, HT and MW, was reported to improve the control of particle size, porosity, and morphology by a better monitoring of process parameters (time, temperature, and energy), with low energy consumption, low temperatures (less than 250 °C), and short time process cycles [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

Nano-Hydroxyapatite vs. Xenografts: Synthesis, Characterization, and In Vitro Behavior

et al. 2021

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This research focused on the synthesis of apatite, starting from a natural biogenic calcium source (egg-shells) and its chemical and morpho-structural characterization in comparison with two commercial xenografts used as a bone substitute in dentistry. The synthesis route for the hydroxyapatite powder was the microwave-assisted hydrothermal technique, starting from annealed egg-shells as the precursor for lime and di-base ammonium phosphate as the phosphate precursor. The powders were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDAX), transmission electron microscopy (TEM), X-ray fluorescence spectroscopy (XRF), and cytotoxicity assay in contact with amniotic fluid stem cell (AFSC) cultures. Compositional and structural similarities or differences between the powder synthesized from egg-shells (HA1) and the two commercial xenograft powders—Bio-Oss®, totally deproteinized cortical bovine bone, and Gen-Os®, partially deproteinized porcine bone—were revealed. The HA1 specimen presented a single mineral phase as polycrystalline apatite with a high crystallinity (Xc 0.92), a crystallite size of 43.73 nm, preferential growth under the c axes (002) direction, where it mineralizes in bone, a nano-rod particle morphology, and average lengths up to 77.29 nm and diameters up to 21.74 nm. The surface of the HA1 nanoparticles and internal mesopores (mean size of 3.3 ± 1.6 nm), acquired from high-pressure hydrothermal maturation, along with the precursor’s nature, could be responsible for the improved biocompatibility, biomolecule adhesion, and osteoconductive abilities in bone substitute applications. The cytotoxicity assay showed a better AFSC cell viability for HA1 powder than the commercial xenografts did, similar oxidative stress to the control sample, and improved results compared with Gen-Os. The presented preliminary biocompatibility results are promising for bone tissue regeneration applications of HA1, and the study will continue with further tests on osteoblast differentiation and mineralization.

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“…Apatite is a big family of compounds, and it is widely investigated due to its outstanding properties such as good biocompatibility or possibility to be doped with different ions in a broad concentration range for applications in the industry, in medicine, etc. There are a lot of papers focusing on apatite synthesis [ 21 , 22 , 23 , 24 ]; its doping with antibacterial ions [ 9 , 10 , 25 ]; as well as its doping with luminescence ions such as Eu 3+ [ 5 , 19 , 26 , 27 ], Tb 3+ [ 28 , 29 ], Eu 3+ /Tb 3+ [ 30 ], Er 3+ /Yb 3+ , or Eu 3+ /Cu 2+ [ 17 ]. Moreover, there is a lot of research focusing on anion-substituted apatite such as silicate [ 31 , 32 ], vanadate [ 33 ], borate [ 34 ], or carbonate [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection

et al. 2021

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The hydroxyapatite nanopowders of the Eu3+-doped, Cu2+-doped, and Eu3+/Cu2+-co-doped Ca10(PO4)6(OH)2 were prepared by a microwave-assisted hydrothermal method. The structural and morphological properties of the products were investigated by X-ray powder diffraction (XRD), transmission electron microscopy techniques (TEM), and infrared spectroscopy (FT-IR). The average crystal size and the unit cell parameters were calculated by a Rietveld refinement tool. The absorption, emission excitation, emission, and luminescence decay time were recorded and studied in detail. The 5D0 → 7F2 transition is the most intense transition. The Eu3+ ions occupied two independent crystallographic sites in these materials exhibited in emission spectra: one Ca(1) site with C3 symmetry and one Ca(2) sites with Cs symmetry. The Eu3+ emission is strongly quenched by Cu2+ ions, and the luminescence decay time is much shorter in the case of Eu3+/Cu2+ co-doped materials than in Eu3+-doped materials. The luminescence quenching mechanism as well as the schematic energy level diagram showing the Eu3+ emission quenching mechanism using Cu2+ ions are proposed. The electron paramagnetic resonance (EPR) technique revealed the existence of at least two different coordination environments for copper(II) ion.

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Regulatory synthesis and characterization of hydroxyapatite nanocrystals by a microwave-assisted hydrothermal method

Cited by 42 publications

References 44 publications

Microwave assistant synthesis of calcium phosphate minerals using hen’s eggshells as a calcium source

Microwave assistant synthesis of calcium phosphate minerals using hen’s eggshells as a calcium source

Nano-Hydroxyapatite vs. Xenografts: Synthesis, Characterization, and In Vitro Behavior

Quenching of the Eu3+ Luminescence by Cu2+ Ions in the Nanosized Hydroxyapatite Designed for Future Bio-Detection

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