Regulatory T cells in allogeneic hematopoietic stem cell transplantation: From the lab to the clinic

Gu, Guang; Yang, Jiping; Zhang, Jinqiao; Sun, Lixin

doi:10.1016/j.cellimm.2019.103991

Cited by 7 publications

(4 citation statements)

References 86 publications

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“…27,28 Besides the protective effect against GVHD, Tregs also seem to be associated with an enhanced graft-vs-leukemia effect and decreased relapse rates. 29 Some studies have investigated the effect of cryopreservation on Treg function, demonstrating a reduction of these cells in peripheral blood following freezing and thawing of samples. 30,31 Other studies have shown that cryopreservation did not affect in vitro cell viability or proliferation capacity of peripheral blood T cells, but may delay activation and alter cytokine production profiles.…”

Section: Discussionmentioning

confidence: 99%

“…Also, CD62L contributes to the in vivo protective effects of CD4+CD25+FoxP3+ regulatory T cells (Tregs) against GVHD 27,28 . Besides the protective effect against GVHD, Tregs also seem to be associated with an enhanced graft‐vs‐leukemia effect and decreased relapse rates 29 . Some studies have investigated the effect of cryopreservation on Treg function, demonstrating a reduction of these cells in peripheral blood following freezing and thawing of samples 30,31 .…”

Section: Discussionmentioning

confidence: 99%

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Fresh vs. frozen allogeneic peripheral blood stem cell grafts: A successful timely option

et al. 2020

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Cryopreservation of grafts has been established in autologous and cord blood transplantation, yet there is little experience regarding the effect of cryopreservation with sibling and unrelated grafts. We evaluated the effect of cryopreservation of grafts on allogeneic transplant outcomes using related, unrelated and haploidentical donors, including 958 patients, age 18-74 years (median 55) and using PBSC for various hematologic malignancies. Fresh grafts were received by 648 (68%) patients, 310 (32%) received cryopreserved. There was no difference between fresh vs cryopreserved grafts for neutrophil engraftment (P = .09), platelet engraftment (P = .11), graft failure (5.6% vs 6.8%, P = .46) and grade II-IV acute graft-vs-host disease (GVHD) (P = .71), moderate/severe chronic GVHD was observed in 176 (27%) vs 123 (40%) patients, respectively (P < .001). Multivariable analysis demonstrated no difference between fresh vs cryopreserved for OS (P = .39) and CIR (P = .08) while fresh grafts demonstrated borderline increased NRM (HR 1.27, 95% CI 1.02-1.59, P = .04). Of note, for patients with no or mild chronic GVHD, CIR was less for fresh compared to cryopreserved (HR = 0.67 for fresh, 95% CI 0.48-0.92, P = .01). We conclude there were no differences in engraftment and survival between fresh and cryopreserved grafts for allogeneic HCT, thus establishing cryopreservation to be a safe option for allogeneic HCT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fresh vs. frozen allogeneic peripheral blood stem cell grafts: A successful timely option

et al. 2020

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“…A subset of Tcell called regulatory T cells (Tregs) plays a vital role in immune homeostasis and peripheral tolerance by various immune functions. Several reports in mice and humans have demonstrated the importance of Treg tolerance following HSCT ( Hanash and Levy, 2005 ; Gu et al, 2019 ; Whangbo et al, 2020 ). In line with this, clinical studies established that Treg could prevent both acute and chronic GVHD through immunomodulatory effects on the immune system ( Edinger et al, 2003 ; Gu et al, 2019 ; Whangbo et al, 2020 ; Guo et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Several reports in mice and humans have demonstrated the importance of Treg tolerance following HSCT ( Hanash and Levy, 2005 ; Gu et al, 2019 ; Whangbo et al, 2020 ). In line with this, clinical studies established that Treg could prevent both acute and chronic GVHD through immunomodulatory effects on the immune system ( Edinger et al, 2003 ; Gu et al, 2019 ; Whangbo et al, 2020 ; Guo et al, 2021 ). In addition, it has been revealed that T reg levels are inversely correlated with disease severity and progression rate ( Valverde-Villegas et al, 2015 ; Romano et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

An Overview of Autophagy in Hematopoietic Stem Cell Transplantation

Montazersaheb

Ehsani

Fathi

et al. 2022

Front. Bioeng. Biotechnol.

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Autophagy is a fundamental homeostatic process crucial for cellular adaptation in response to metabolic stress. Autophagy exerts its effect through degrading intracellular components and recycling them to produce macromolecular precursors and energy. This physiological process contributes to cellular development, maintenance of cellular/tissue homeostasis, immune system regulation, and human disease. Allogeneic hematopoietic stem cell transplantation (HSCT) is the only preferred therapy for most bone marrow-derived cancers. Unfortunately, HSCT can result in several serious and sometimes untreatable conditions due to graft-versus-host disease (GVHD), graft failure, and infection. These are the major cause of morbidity and mortality in patients receiving the transplant. During the last decade, autophagy has gained a considerable understanding of its role in various diseases and cellular processes. In light of recent research, it has been confirmed that autophagy plays a crucial role in the survival and function of hematopoietic stem cells (HSCs), T-cell differentiation, antigen presentation, and responsiveness to cytokine stimulation. Despite the importance of these events to HSCT, the role of autophagy in HSCT as a whole remains relatively ambiguous. As a result of the growing use of autophagy-modulating agents in the clinic, it is imperative to understand how autophagy functions in allogeneic HSCT. The purpose of this literature review is to elucidate the established and implicated roles of autophagy in HSCT, identifying this pathway as a potential therapeutic target for improving transplant outcomes.

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Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study

et al. 2021

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Regulatory T cells in allogeneic hematopoietic stem cell transplantation: From the lab to the clinic

Cited by 7 publications

References 86 publications

Fresh vs. frozen allogeneic peripheral blood stem cell grafts: A successful timely option

Fresh vs. frozen allogeneic peripheral blood stem cell grafts: A successful timely option

An Overview of Autophagy in Hematopoietic Stem Cell Transplantation

Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study

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