Regulatory T Cells in Bioactive Peptides-Induced Oral Tolerance; a Two-Edged Sword Related to the Risk of Chronic Diseases: A Systematic Review

Barati, Meisam; Jabbari, Masoumeh; Nickho, Hamid; Esparvarinha, Mojgan; Mamaghani, Amirreza Javadi; Majdi, Hasan Shakir; Fathollahi, Anwar; Davoodi, Sayed Hossein

doi:10.1080/01635581.2020.1784442

Cited by 10 publications

(15 citation statements)

References 73 publications

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“…21,23,24 Induction of OT vs collagen is one of the approaches to suppressing the immune response against collagen in the body. 15,25 OT is a type of immune system tolerance. OT is the situation of the immune system's unresponsiveness to the content of the gastrointestinal tract (GIT).…”

Section: Discussionmentioning

confidence: 99%

“…After the evaluation of dietary proteins by GALT, the immune system begins to suppress any immune responses against the proteins in the body. 15,25 Under normal physiological conditions, GALT tolerates all of the ingested dietary proteins. Sometimes, under pathological conditions (ie food allergies and celiac disease) OT is inefficient to suppress the immune response against the dietary proteins.…”

Section: Discussionmentioning

confidence: 99%

“…13 This peripheral tolerance can cause immune unresponsiveness vs joint collagen, as regulatory T cells (T-reg) induction produces anti-inflammatory cytokines, thus suppressing inflammation. 14,15 In addition, anti-inflammatory cytokines can stimulate chondrocytes, which synthesize cartilage matrix components. 16 Further, supplementation of cartilage components containing collagen is often beneficial to suppress pain associated with arthritis, including RA and OA.…”

Section: Introductionmentioning

confidence: 99%

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Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review

et al. 2022

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Rheumatoid arthritis (RA) and osteoarthritis (OA) both are chronic diseases affecting joints. Immune response against collagen in both diseases may have a role in the initiation and progression of the disease. There is a hypothesis that suppression of immune response vs collagen could be a therapeutic approach in RA and OA. Exposure of gut immune system to collagen is a way to suppress immune response against collagen in the joints. So, the current systematic review is aimed to evaluate the effects of collagen supplementation in OA and RA patients. In the current systematic review, online electronic databases including PubMed/MEDLINE, Web of Sciences and Scopus were searched and finally 19 articles were included. The enrolled articles evaluated the effects of collagen supplementation on treatment of OA (n = 9) and RA (n = 10). Intact (n = 4) and hydrolyzed (n = 5) collagen were used to treat OA. All of the studies on RA used intact and type II collagen in their intervention. The last trials on collagen supplementation in RA and OA patients were performed in 2011 and 2016, respectively. High adverse effects of collagen supplementation and its low efficiency compared to routine treatments were reported by several included studies. Also, risk of bias assessment showed that most of the studies had poor quality. Therefore, it is not possible to definitely decide on the beneficial or detrimental effects of collagen supplementation on OA and RA patients. Further studies are needed to reach a final decision.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review

et al. 2022

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“…During the assessment of dietary proteins by GALT, several active fragments in the parent proteins are identified, and after identification of the active encrypted peptide fragments, the GALT begins to suppress any immune responses against the fragments in the body. The process in which the immune response against the dietary active peptide fragments is suppressed is called oral tolerance, and the active encrypted peptide fragments are known as epitopes (Barati et al, 2020a;Pabst & Mowat, 2012). In physiological conditions, the body's immune system tolerates all of the dietary proteins.…”

Section: Evaluation Of Different Types Of Milk Proteins-derived Epitopes Using In-silico Tools: a Primarily Study To Propose A New Definimentioning

confidence: 99%

“…BPs are food-derived peptides whose usefulness is beyond the supply of the body amino-acids (Barati, 2020b;Büyükcan & Karakaya, 2021). Anti-inflammatory, anticancer and, anti-hypertensive roles are some of the beneficial effects of the peptides on the body systems (Barati et al, 2020a;Navarro-Peraza et al, 2020). While the absorbability and digestion-resistance are inevitably required for a peptide to exert its effects.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of different types of milk proteins-derived epitopes using in-silico tools: a primarily study to propose a new definition for bioactive peptides

et al. 2022

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Bioactive peptides are digestion-resistant and absorbable peptides released from dietary parent proteins. Dietary epitopes exert their effects on the body without absorption and release from parent protein. In this study, the epitope content of milk proteins was discovered, and a new definition for BPs is provided alongside the classic definition. In this study, LBtope, ABCpred, and SVMTriP servers were used to find Linear B cell epitopes. Besides, to predict T cell epitopes, the major histocompatibility complex I (MHC-I) and MHC-II alleles that were more abundant among Iranian people were first found from the Allele Frequency Net Database (AFND). Consequently, the IEDB, RANKPEP, SYFPEITHI, EpiJen, and EpiTOP3 servers were used for MHC binding epitopes. In the current study, MHC-II, MHC-I, and B-cell epitopes of milk proteins were discovered. The most important B-cell epitopes discovered by LBtope, ABCpred, and SVMtrip databases for α S1 -casein included , . The high rank of α S1 -casein derived from MHC-II epitopes and discovered from the SYFPEITHI database included . The epitopes of dietary proteins and endogenous proteins could be considered as BPs. Epitopes exert their biological effects without absorption and release from parent proteins.

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Co‐administration of probiotic and vitamin D significantly improves cognitive function in schizophrenic patients: A double‐blinded randomized controlled trial

Mohammadi,

Sadighi,

Nazeri Astaneh

et al. 2024

Neuropsychopharm Rep

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AimManipulation of the intestinal microbiome and supplying vitamin D can attenuate psychiatric symptoms in schizophrenic patients. The current study tried to evaluate the effects of probiotic/vitamin D supplementation on the cognitive function and disease severity of schizophrenic patients.MethodsIn the present study, 70 patients (aged 18–65) with schizophrenia were recruited. Participants were randomly allocated to the placebo (n = 35) and intervention (probiotic supplements+400 IU vitamin D, n = 35) groups. Severity of disease and cognitive function (primary outcomes) were evaluated by Positive and Negative Syndrome Scale (PANSS) and Montreal Cognitive Assessment (MoCA) tests, respectively. Moreover, lipid profile, body mass index (BMI), gastrointestinal (GI) problems, serum C‐reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated as secondary outcomes.ResultsA total of 69 patients completed the study. The MoCA score was increased by 1.96 units in the probiotic‐containing supplement group compared to the placebo (p = 0.004). Also, the percentage of subjects with MoCA score ≥ 26 rose significantly in the intervention group (p = 0.031). Moreover, TC (p = 0.011), FBS (p = 0.009), and CRP (p < 0.001) significantly decreased in the supplement group compared to the placebo. Although the probiotic supplement reduced PANSS score by 2.82 units, the difference between the study groups was not statistically significant (p = 0.247).ConclusionCo‐administration of probiotics and vitamin D has beneficial effects on the improvement of cognitive function in schizophrenic patients.

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Regulatory T Cells in Bioactive Peptides-Induced Oral Tolerance; a Two-Edged Sword Related to the Risk of Chronic Diseases: A Systematic Review

Cited by 10 publications

References 73 publications

Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review

Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review

Evaluation of different types of milk proteins-derived epitopes using in-silico tools: a primarily study to propose a new definition for bioactive peptides

Co‐administration of probiotic and vitamin D significantly improves cognitive function in schizophrenic patients: A double‐blinded randomized controlled trial

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