Rehabilitation programme after stem cell transplantation: randomized controlled trial

Bird, Lydia; Arthur, Antony; Niblock, Tara; Stone, Rebecca; Watson, Lynn Ann; Cox, Karen

doi:10.1111/j.1365-2648.2009.05232.x

Cited by 17 publications

(33 citation statements)

References 25 publications

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“…The database search identified 12 270 articles. Thirty‐nine articles met the Tools Criteria and reported some validation of a HRQOL instrument in myeloma . Seven articles met the Issues Criteria and used inductive methods to identify HRQOL issues important to patients with myeloma .…”

Section: Resultsmentioning

confidence: 99%

What issues matter most to people with multiple myeloma and how well are we measuring them? A systematic review of quality of life tools

Osborne

Ramsenthaler

Siegert

et al. 2012

European J of Haematology

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Introduction: Treatment advances in multiple myeloma have increased expected survival from months to years for some patients. Alongside improved survival emerges a need to better understand and measure health-related quality of life (HRQOL), both in research and clinical settings. Objectives: (i) Identify HRQOL tools validated for use in myeloma; (ii) identify issues important to HRQOL from the point of view of patients with myeloma; (iii) describe the measurement properties of each HRQOL tool; (iv) evaluate the content validity of HRQOL tools in terms of their ability to capture all issues important to patients and (v) explore the suitability of each HRQOL tool for use in different settings. Method: Systematic literature review of six databases with no limits by date or language. Results: Thirty-nine studies reported validation of 13 HRQOL instruments. Seven studies identified issues important to HRQOL from the patients' perspective. No instrument was comprehensive to all issues important to patients. The EORTC-QLQ-C30 and MY24 have undergone the most comprehensive psychometric validation. Most validation occurred in trial patients and not clinically representative groups. No studies evaluated clinical utility of tools alongside routine practice. Conclusion: The best existing HRQOL tools are designed predominantly for use in research. Reliable, valid and responsive tools exist for this purpose, but may miss issues important to patients. The design of HRQOL measures should be guided by intended utility, whether for research or clinical practice, and further validation of HRQOL tools in clinically representative groups is needed. Development and validation of HRQOL tools for clinical use may be of value.

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Section: Resultsmentioning

confidence: 99%

What issues matter most to people with multiple myeloma and how well are we measuring them? A systematic review of quality of life tools

Osborne

Ramsenthaler

Siegert

et al. 2012

European J of Haematology

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“…A full description of the trial and the quantitative results are reported elsewhere [8] but brief details are provided here to give context to the qualitative study that is the focus of this paper.…”

Section: Methodsmentioning

confidence: 99%

"Did the trial kill the intervention?" experiences from the development, implementation and evaluation of a complex intervention

Bird

Arthur

Cox

2011

BMC Med Res Methodol

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BackgroundThe development, implementation and evaluation of any new health intervention is complex. This paper uses experiences from the design, implementation and evaluation of a rehabilitation programme to shed light on, and prompt discussion around, some of the complexities involved in such an undertaking.MethodsSemi-structured interviews were conducted with 15 trial participants and five members of staff at the conclusion of a trial evaluating a rehabilitation programme aimed at promoting recovery after stem cell transplantation.ResultsThis study identified a number of challenges relating to the development and evaluation of complex interventions. The difficulty of providing a standardised intervention that was acceptable to patients was highlighted in the participant interviews. Trial participants and some members of staff found the concept of equipoise and randomisation challenging and there was discord between the psychosocial nature of the intervention and the predominant bio-medical culture in which the research took place.ConclusionsA lack of scientific evidence as to the efficacy of an intervention does not preclude staff and patients holding strong views about the benefits of an intervention. The evaluation of complex interventions should, where possible, facilitate not restrict that complexity. Within the local environment where the trial is conducted, acquiescence from those in positions of authority is insufficient; commitment to the trial is required.

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“…Hematopoietic stem cell transplantation (HSCT) is routinely used in the treatment of hematological malignancies (Bird et al ., 2010), including leukemia. Nearly 100 000 patients are now treated annually with HSCT worldwide (Gratwohl et al ., 2008).…”

Section: Introductionmentioning

confidence: 99%

Coping strategies of adults with leukemia undergoing hematopoietic stem cell transplantation in Iran: a qualitative study

Farsi

Nayeri

Negarandeh

2010

Nursing & Health Sciences

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Hematopoietic stem cell transplantation (HSCT) causes significant physical, social, psychological, and emotional stress in patients with leukemia. This qualitative study using semi-structured interviews explored the coping strategies of 10 adults with acute leukemia who were undergoing this form of treatment in transplantation units in a major hospital in Tehran, Iran, from 2009 to 2010. A content analysis identified eight themes and 13 subthemes that described the participants' coping strategies. The major themes were: attribution, denial and avoidance, connection with divine purpose, organizing treatment, seeking social support, modifying, reflection, and patience and resignation. A deeper understanding of the coping strategies that are used by patients with leukemia undergoing HSCT can help healthcare providers to encourage patients to use strategies that are likely to be more effective. Such coping strategies also can help patients to achieve a greater sense of empowerment.

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Rehabilitation programme after stem cell transplantation: randomized controlled trial

Abstract: One approach for providing a flexible service may be for staff and individual patients to work together, selecting from a series of specified options a programme with the appropriate content and duration to meet that individual's needs.

Cited by 17 publications

References 25 publications

What issues matter most to people with multiple myeloma and how well are we measuring them? A systematic review of quality of life tools

What issues matter most to people with multiple myeloma and how well are we measuring them? A systematic review of quality of life tools

"Did the trial kill the intervention?" experiences from the development, implementation and evaluation of a complex intervention

Coping strategies of adults with leukemia undergoing hematopoietic stem cell transplantation in Iran: a qualitative study

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