The tourism industry includes air, sea, and land transportation; food supply chain; accommodation; entertainment; recreation; etc. services. Hence, tourism businesses are proposing changes, and post-COVID tourists will not be the same as pre-COVID ones. Innovative solutions regarding safety and hygiene measures as well as the proximity of medical facilities will be of key importance in meeting the tourist expectations and sustainability of the tourism industry. In addition, it is possible to state that the COVID-19 pandemic has affected the whole world. This situation caused the economic balances of countries to deteriorate and some sectors to be adversely affected. The most affected sector is undoubtedly the tourism industry. Innovation has gained more importance in the tourism industry in the context of sustainability of tourism with the COVID-19 pandemic process. In this context, this chapter aimed to examine how innovation can contribute to the sustainability of post-COVID tourism.