Reinforcing the function of bone graft via the Ca-P ceramics dynamic behavior-enhanced osteogenic microenvironment for optimal bone regeneration and reconstruction

Wu, Jinjie; Zhang, Rongfeng; Li, Yang; Zhu, Xiupeng; Chen, Xuening; Weng, Jie; Zhi, Wei; Wang, Jianxin; Xie, Zhiyong; Zhang, Xingdong

doi:10.1016/j.apmt.2022.101465

Cited by 3 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous studies have shown that appropriate MVS (intensity at 0.3 g, frequency at 40 Hz and 30 min/24 h) can not only promote the proliferation, adhesion and osteogenic differentiation of BMSCS and osteoblasts, but also enhance their mechanical adaptability and cell activity [ 20 , 39 ]. In addition, our previous work also confirmed that MVS with the same parameters can promote calcium release, protein adsorption and mineralization deposition of calcium phosphate bioceramic scaffolds [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Wu,

Huang

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Wu,

Huang

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

Coupling BCP Ceramics with Micro‐Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

Wang

et al. 2023

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

The osteoimmunology has revealed that immune system plays an important role in maintaining bone metabolism and remodeling. As long‐term physiological factor in bone, mechanical stimulation such as micro‐vibration stimulation (MVS) exerts effects on regulating osteogenesis and immune response. In this study, the osteo‐immunodulatory effects of bicalcium phosphate (BCP) ceramics coupled with MVS are investigated. This results find that the combination of BCP ceramics and MVS may exert synergistic effects on the polarization and functional status of macrophages through activating plasma membrance Ca2+ ATPase (PMCA) channel, reducing the intracellular calcium ion concentration, and inhibiting downstream extracellular signal‐regulated kinase (ERK)1/2 signaling pathway. BCP ceramics coupled MVS could drive the macrophage polarization to wound‐healing M2 phenotype to decrease the production of pro‐inflammatory factors, enhance the secretion of anti‐inflammatory cytokines and growth factors such as transforming growth factor (TGF)‐β1 and bone morphogenetic protein (BMP)‐2. Moreover, BCP and MVS‐modulated macrophage secretion pattern can trigger the BMP/TGF‐Smad signaling pathways to induce osteoblastic differentiation of bone marrow mesenchymal stromal cells (BM‐MSCs) in vitro, and maintain cellular viability and promote the formation of collagen‐rich osteoid like tissues and mature blood vessels in vivo. This study demonstrates that the introduction of mechanical stimuli like non‐invasive MVS is an effective strategy to improve bone repair effects of biomaterials through endowing them with superior osteo‐immunodulatory capacity.

show abstract

Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures

He,

Du,

Wang

et al. 2024

Journal of Materials Research and Technology

View full text Add to dashboard Cite

Reinforcing the function of bone graft via the Ca-P ceramics dynamic behavior-enhanced osteogenic microenvironment for optimal bone regeneration and reconstruction

Cited by 3 publications

References 48 publications

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation

Coupling BCP Ceramics with Micro‐Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures

Contact Info

Product

Resources

About