Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis

Evans, Adam; Ivanic, Mirjana G; Botros, Mina; Pope, Rand W.; Halle, Briana R.; Glassman, Gabriella E.; Genova, Rafaella; Kassis, Salam Al

doi:10.1007/s00403-020-02173-z

Cited by 22 publications

(21 citation statements)

References 67 publications

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“…There are a variety of treatment options to mitigate the signs of periorbital skin aging, including topical retinoids, 13 radiofrequency, 14,15 broadband infrared, 16 intense pulsed light, 17 chemical peels, 18 botulinum toxin, 19 and platelet‐rich plasma (PRP), 5 and non‐ablative and ablative laser resurfacing procedures 15,20 . Full surface and fractional ablative resurfacing procedures are effective in improving periorbital wrinkles and laxity, but, because the epidermis is ablated, the recovery may take 1–2 weeks, and posttreatment erythema and hyperpigmentation commonly emerge, especially in darker skin types.…”

Section: Discussionmentioning

confidence: 99%

“…Aggressive invasive procedures are more likely to yield improved cosmesis but can result in longer downtime and a higher rate of adverse effects. [3][4][5][6][7][8] Non-ablative fractional 1565 nm Er:glass fiber laser (NAFL), was recently demonstrated to offer a mildmoderate improvement in periorbital wrinkling, 9 and was cleared for marketing this indication by the US Food and Drug Administration (FDA).…”

Section: Introductionmentioning

confidence: 99%

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Treatment of periorbital wrinkles using thermo‐mechanical fractional injury therapy versus fractional non‐ablative 1565 nm laser: A comparative prospective, randomized, double‐arm, controlled study

et al. 2021

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Background: Non-ablative fractional laser is an effective modality for the treatment of periorbital wrinkling, one of the earliest signs of skin aging. Thermomechanical fractional injury (TMFI) therapy (Tixel ® , Novoxel ® , Israel) is an innovative technology that is now being used for facial skin rejuvenation. Our study compares the clinical results, side effects, and downtime profile between TMFI treatment and non-ablative fractional 1565 nm laser (ResurFX ® , Lumenis, Israel). METHODS: This was a prospective study of 68 patients (64 women, 4 men) with skin types I-VI in two medical centers (34 from Israel, 34 from the USA) that were randomized to receive either TMFI or NAFL treatment for periorbital wrinkling. Patients received 3-5 treatments, 3-5 weeks apart. Six months after the last treatment, the change in Fitzpatrick Wrinkling Classification System (FWCS) was calculated by three non-involved physicians and compared to pretreatment results. Side effects and downtime profiles were assessed in each group (including VAS pain assessment, time required to refrain from work and social activity, and time required for the resolution of redness, edema, and crusts.) RESULTS: A moderate improvement in periorbital wrinkling was demonstrated in both groups, with an average improvement of 1.6 ± 0.6 in FWCS in the TMFI group and an average improvement of 1.7 ± 0.8 in the NAFL group (p < 0.001). Postprocedural VAS score was 5.86 ± 2.3 in the NAFL group and 4.01 ± 2.6 in the Tixel ® group. Approximately 80% of subjects returned to both work and social activities two days postprocedure. Crusts were reported by 52% of patients in the TMFI group, compared to 16% of patients in the NAFL group more than 48 hours postprocedure (p < 0.05). There were no statistically significant differences in the other parameters between the two groups. CONCLUSION: TMFI is an effective and safe modality for the treatment of periorbital wrinkling, with comparable results to the 1565 nm NAFL.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment of periorbital wrinkles using thermo‐mechanical fractional injury therapy versus fractional non‐ablative 1565 nm laser: A comparative prospective, randomized, double‐arm, controlled study

et al. 2021

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“…Injection of platelet‐rich plasma (PRP) is the most popular one that can improve facial skin appearance (texture and lines), increase skin thickness and enhance collagen content. 24 , 25 However, this technique lacks standard of preparation, contains cellular residues and cannot be stored, resulting in less than 50% global improvements rate and unsatisfactory efficacy in clinic. 25 , 26 Therefore, it is necessarily needed to develop new techniques with certain effectiveness for skin ageing treatment.…”

Section: Introductionmentioning

confidence: 99%

“… 24 , 25 However, this technique lacks standard of preparation, contains cellular residues and cannot be stored, resulting in less than 50% global improvements rate and unsatisfactory efficacy in clinic. 25 , 26 Therefore, it is necessarily needed to develop new techniques with certain effectiveness for skin ageing treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, cell therapy‐based techniques have attracted increasing attention in the field of anti‐ageing. Injection of platelet‐rich plasma (PRP) is the most popular one that can improve facial skin appearance (texture and lines), increase skin thickness and enhance collagen content 24,25 . However, this technique lacks standard of preparation, contains cellular residues and cannot be stored, resulting in less than 50% global improvements rate and unsatisfactory efficacy in clinic 25,26 .…”

Section: Introductionmentioning

confidence: 99%

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Growth factors‐based platelet lysate rejuvenates skin against ageing through NF‐κB signalling pathway: In vitro and in vivo mechanistic and clinical studies

Lu²,

Zhou

et al. 2022

Cell Proliferation

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Introduction Platelets benefit tissue regeneration by secreting growth factors, and platelet products, for example, platelet lysate (PL), have been clinically applied for tissue rejuvenation. To determine the anti‐ageing efficacy and mechanism of human PL (hPL) on skin, this study conducted clinical retrospective analysis, nude mice‐based in vivo study and human dermal fibroblasts (HDFs)‐based in vitro study. Methods Flow cytometry was employed for quality control of hPL, and ELISA was used for quantification of growth factors (EGF, IGF‐1, PDGF and TGF‐β) in hPL. After d ‐galactose modelling, skin texture grading, histopathological observation, immunofluorescence analysis and oxidative stress assays were conducted on nude mice, while SA‐β‐gal staining, CCK‐8 and wound healing assays were conducted on HDFs. qPCR and western blot were conducted to clarify hPL's mechanism. Results The clinical retrospective data showed that hPL obviously rejuvenated human skin appearances without adverse events. The animal data showed that hPL exerted rejuvenative effects on skin, and the cellular data showed that hPL significantly promoted the proliferation and migration of HDFs and suppressed senescence‐associated secretory protein secretion and senescence state of senescent HDFs by suppressing NF‐κB pathway. The NF‐κB‐dependent mechanism was verified positively by using P65 siRNA and negatively by using prostratin. Furthermore, EGF, IGF‐1, PDGF and TGF‐β were found as the main ingredients in hPL, which contributed to the efficacy and mechanism of hPL. Conclusion This study provided novel knowledge of hPL, making it ideal for skin rejuvenation.

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Applications of Plasma‐Rich Plasma, Exosomes, and Stem Cells in Aesthetics: A Narrative Review

Ablon,

Smith,

Munavalli

2024

Dermatological Reviews

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IntroductionPlasma‐rich plasma (PRP), exosomes, and stem cells represent promising new treatments for facial rejuvenation and to enhance other cosmetic procedures. Although these treatments are rapidly advancing, there are no universally accepted treatment protocols for their use. The goal of the following review is to describe some of the possible benefits of PRP, exosomes, and stem cells in aesthetic medicine.ResultsA review of available studies showed that potential uses of PRP include wound healing after facial surgery, facial rejuvenation, androgenetic alopecia, acne scars, striae distensae, and vitiligo. Exosomes may provide beneficial treatment for skin rejuvenation, scar reduction, hyperpigmentation, and hair growth. Stem cells show promise for androgenetic alopecia, scar improvement, and treatment of photoaged skin. These new technologies may be used alone, but are often combined with existing aesthetic treatments.ConclusionPRP, exosomes, and stem cells may play an important role in restoring youthful tissue structure and function. Interpretation of some study results is sometimes challenged by the lack of standardized treatment protocols, including routes of application and dosing. When combined with other devices and techniques, results are sometime unclear as to which treatment plays the greater role.

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Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis

Cited by 22 publications

References 67 publications

Treatment of periorbital wrinkles using thermo‐mechanical fractional injury therapy versus fractional non‐ablative 1565 nm laser: A comparative prospective, randomized, double‐arm, controlled study

Treatment of periorbital wrinkles using thermo‐mechanical fractional injury therapy versus fractional non‐ablative 1565 nm laser: A comparative prospective, randomized, double‐arm, controlled study

Growth factors‐based platelet lysate rejuvenates skin against ageing through NF‐κB signalling pathway: In vitro and in vivo mechanistic and clinical studies

Applications of Plasma‐Rich Plasma, Exosomes, and Stem Cells in Aesthetics: A Narrative Review

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