Relación entre las concentraciones de la leptina y la actividad de la enfermedad en pacientes con artritis reumatoide

Batún-Garrido, José Antonio de Jesús; Salas‐Magaña, Marisol; Juárez‐Rojop, Isela Esther; Hernández-Núñez, Éufrates; Olán, Francisco

doi:10.1016/j.medcli.2017.10.020

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Several studies have shown that serum leptin concentration was independently associated with the DAS-28 score. 66 This evidence is also valid for the synovial leptin concentration as well, in fact the synovial/serum leptin ratio was significantly higher in erosive RA than in non-erosive RA, which in turn was higher than the synovial leptin concentration in healthy controls. 67 A study in patients treated with anti-TNF-alfa also showed a positive correlation between the serum level of leptin and DAS 28 and, in conjunction with a good clinical response, both leptin and DAS 28 lower their score after treatment with anti-TNF-alfa.…”

Section: Leptinmentioning

confidence: 62%

Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases

Giardullo

Corrado

Maruotti

et al. 2021

Int J Immunopathol Pharmacol

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We performed a systematic literature review to summarize the underlying pathogenic mechanisms by which adipokines influence rheumatological diseases and the resulting clinical manifestations. Increasing evidence display that numerous adipokines may significantly influence the development or clinical course of various rheumatological diseases. Despite the normal anti- or pro-inflammatory role of the cytokines, the serum level varies enormously in various rheumatological diseases. The expression of high levels of pro-inflammatory cytokines such as leptin or visfatin, respectively in systemic lupus erythematosus and in rheumatoid arthritis, represents a negative prognostic factor; other adipokines such as adiponectin, broadly known for their anti-inflammatory effects, showed a correlation with disease activity in rheumatoid arthritis. In the near future pro-inflammatory cytokines may represent a potential therapeutic target to restrain the severity of rheumatological diseases. Further studies on adipokines may provide important information on the pathogenesis of these diseases, which are not yet fully understood. The mechanisms by which adipokines induce, worsen, or suppress inflammatory and degenerative musculoskeletal pathologies and their clinical significance will be discussed in this review.

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Section: Leptinmentioning

confidence: 62%

Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases

Giardullo

Corrado

Maruotti

et al. 2021

Int J Immunopathol Pharmacol

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“…The serum level of Lp inversely correlates with circulating Treg lymphocytes, and thus in SLE, Lp can disrupt the regulatory mechanism of adaptive immunity [ 59 ]. A positive correlation between CRP and Lp levels was shown [ 250 ]. Patients with RA demonstrated increased Lp levels [ 251 ]; those with positive ACCP and obesity exhibited higher levels of Lp [ 250 ].…”

Section: Aptamers For Protein Biomarkers Of Rheumatic Disordersmentioning

confidence: 99%

“…A positive correlation between CRP and Lp levels was shown [ 250 ]. Patients with RA demonstrated increased Lp levels [ 251 ]; those with positive ACCP and obesity exhibited higher levels of Lp [ 250 ]. In synovial fluid, higher Lp levels are also noticed in comparison to osteoarthritis patients [ 252 , 253 ].…”

Section: Aptamers For Protein Biomarkers Of Rheumatic Disordersmentioning

confidence: 99%

Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications

et al. 2020

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Nucleic acid aptamers capable of affine and specific binding to their molecular targets have now established themselves as a very promising alternative to monoclonal antibodies for diagnostic and therapeutic applications. Although the main focus in aptamers’ research and development for biomedicine is made on cardiovascular, infectious, and malignant diseases, the use of aptamers as therapeutic or diagnostic tools in the context of rheumatic diseases is no less important. In this review, we consider the main features of aptamers that make them valuable molecular tools for rheumatologists, and summarize the studies on the selection and application of aptamers for protein biomarkers associated with rheumatic diseases. We discuss the progress in the development of aptamer-based diagnostic assays and targeted therapeutics for rheumatic disorders, future prospects in the field, and issues that have yet to be addressed.

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Rheumatoid arthritis: influence of inflammation and anti-inflammatory therapy on cardiovascular risk factors

2020

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Rheumatoid arthritis is a frequent and one of the most severe immuno-inflammatory diseases in humans, which determines the great medical and socio-economic importance of this pathology. One of the priority problems of modern cardiac rheumatology is an increased risk of cardiovascular complications in rheumatoid arthritis. In patients with rheumatoid arthritis, traditional cardiovascular risk factors for cardiovascular diseases (metabolic syndrome, obesity, dyslipidemia, arterial hypertension, insulin resistance, diabetes mellitus, smoking and hypodynamia) and a genetic predisposition are expressed. Their specific features also have a certain effect: the “lipid paradox” and the “obesity paradox”. However, chronic inflammation as a key factor in the development of progression of atherosclerosis and endothelial dysfunction plays a leading role in morbidity and mortality from cardiovascular diseases in rheumatoid arthritis. This review discusses the effect of chronic inflammation and its mediators on traditional cardiovascular risk factors and its independent significance in the development of CVD. Drug therapy (non-steroidal anti-inflammatory drugs, glucocorticosteroids, basic anti-inflammatory drugs, genetically engineered biological drugs) of the underlying disease also has a definite effect on cardiovascular risk factors in patients with rheumatoid arthritis. A review of studies on this problem suggests a positive effect of pharmacological intervention in rheumatoid arthritis on cardiovascular risk factors, their reduction to a level comparable to the populations of patients not suffering from rheumatoid arthritis. The interaction of rheumatologists, cardiologists and first-contact doctors (therapist and general practitioner) in studying the mechanisms of the development of atherosclerosis in patients with rheumatoid arthritis will allow in real clinical practice to develop adequate methods for the timely diagnosis and prevention of cardiovascular diseases in patients with rheumatoid arthritis.

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Relación entre las concentraciones de la leptina y la actividad de la enfermedad en pacientes con artritis reumatoide

Cited by 4 publications

References 10 publications

Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases

Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases

Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications

Rheumatoid arthritis: influence of inflammation and anti-inflammatory therapy on cardiovascular risk factors

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