Relapse-Free Course in Nearly Half of Crohn’s Disease Patients With Infliximab and Plant-Based Diet as First-Line Therapy: A Single-Group Trial

Chiba, Mitsuro; Tsuji, Takeshi; Nakane, Kunio; Tsuda, Satoko; Ohno, Hideo; Sugawara, K.; Komatsu, Masafumi; Tozawa, Haruhiko

doi:10.7812/tpp/21.073

Cited by 9 publications

(24 citation statements)

References 73 publications

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“…Reflecting the relapse-free course, the cumulative surgical rate at 5 and 10 years was 12% and 19%, respectively. Our surgical rates were lower than those reported ( Table 5 ) [ 84 , 86 , 87 , 88 , 89 , 90 , 91 ].…”

Section: Plant-based Diets For Ibdcontrasting

confidence: 89%

“…It is acknowledged that the evidence level of our single-group studies with small numbers of cases is low compared to conventional randomized controlled trials. By replacing a westernized diet with PBD, however, we consistently observed far better outcomes in both UC and CD in either the active or quiescent stage compared to the current standard [ 5 , 62 , 68 , 84 , 100 , 101 ]. PBDs are effective for all degrees of severity, from mild to severe, in both diseases.…”

Section: Discussionmentioning

confidence: 83%

“…Preliminary follow-up studies indicated that the relapse rate was lower in newly diagnosed adult CD patients than in relapsed adults and newly diagnosed children [ 62 ]. We followed 24 newly diagnosed adult CD patients who were inducted into remission with IPF therapy ( Figure 13 ) [ 84 ]. No biologics, immunosuppressants, or glucocorticoids were administered.…”

Section: Plant-based Diets For Ibdmentioning

confidence: 99%

“…No biologics, immunosuppressants, or glucocorticoids were administered. The cumulative relapse-free rate was 52% at 10 years ( Table 5 , Figure 14 ) [ 58 , 59 , 60 , 84 ]. Solberg et al [ 60 ] described four clinical courses in 191 CD patients in Norway: (1) decreasing severity of relapses, (2) increasing severity of relapses, (3) chronic continuous symptoms, and (4) chronic relapsing symptoms ( Figure 15 ).…”

Section: Plant-based Diets For Ibdmentioning

confidence: 99%

“…We tell patients that PBD is more important than medication for relapse prevention. This might explain why our patients showed significantly higher PBDS relative to baseline even several years after the introduction of PBD [ 84 ]. It seems that patients accepted PBD as a lifestyle.…”

Section: Plant-based Diets For Ibdmentioning

confidence: 99%

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Incorporation of Plant-Based Diet Surpasses Current Standards in Therapeutic Outcomes in Inflammatory Bowel Disease

Chiba

Morita²

2023

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There has been no study of the therapeutic effect of a plant-based diet (PBD) in inflammatory bowel disease (IBD) except for our studies in Japan. In this review, we describe the rationale for the requirement of PBD in IBD and the outcomes of our modality incorporating PBD together with a literature review. The biggest problem in current therapy for IBD is the lack of a widely appreciated ubiquitous environmental factor in IBD. Therefore, a radical strategy against IBD has not been established. Japanese data showed an increased incidence of IBD in association with dietary westernization. Current global consumption consists of an excess of unhealthy foods and a shortage of healthy foods recognized as pro-inflammatory. Patients with IBD are no exception. One of the recommended healthy reference diets is PBD recognized as anti-inflammatory. We assert that IBD occurs in susceptible individuals mainly as a result of our omnivorous (westernized) diet. Therefore, we developed and began to provide a PBD, a lacto-ovo-vegetarian diet, for IBD patients in 2003. Infliximab and PBD as first-line (IPF) therapy was administered for all patients with newly developed Crohn’s disease (CD) and for severe ulcerative colitis (UC). Our modality broke the barrier of primary nonresponders to biologics, with a remission rate of 96% in CD, and created a new relapse-free course in slightly over half of the patients (52%) with CD. Based on the rationale derived from available evidence and the clinical outcomes, PBD is highly recommended for IBD.

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