Relapse in Chronic Myeloid Leukemia after Bone Marrow Transplantation: Biomathematical Modeling as a New Approach to Understanding Pathogenesis

Abstract

We suggest that this biomathematical model should be further investigated as a possible means of predicting outcome and guiding the treatment for patients with CML relapsing after BMT. Stem Cells

A Mathematical Model of the Transition from the Normal Hematopoiesis to the Chronic and Accelerated Acute Stages in Myeloid Leukemia

“…For more recent contributions we refer to Fokas et al [6], Neiman [7], Andersen and Mackey [8], Colijn and Mackey [9], Adimy et al [10], Dingli and Michor [11], Kim et al [12], Cucuianu and Precup [13], Doumic-Jauffret et al [14], Komarova [15], Stiehl and Marciniak-Czochra [16], MacLean et al [17,18], Radulescu et al [19], Bianca et al [20,21], Ragusa and Russo [22], and to the references therein. For some models concerning stem cell transplantation, we mention the papers of Vincent et al [23], De Conde et al [24], Kim et al [25], Marciniak-Czochra and Stiehl [26], Precup et al [27,28], Precup [29] and Stiehl et al [30]. Some review works on mathematical models for cancer, particularly for chronic myeloid leukemia, are the papers of Afenya [31], Michor [32], Foley and Mackey [33], Clapp and Levy [34].…”

A Mathematical Model of the Transition from Normal Hematopoiesis to the Chronic and Accelerated-Acute Stages in Myeloid Leukemia

“…For more recent contributions we refer to Fokas et al [6], Neiman [7], Andersen and Mackey [8], Colijn and Mackey [9], Adimy et al [10], Dingli and Michor [11], Kim et al [12], Cucuianu and Precup [13], Doumic-Jauffret et al [14], Komarova [15], Stiehl and Marciniak-Czochra [16], MacLean et al [17,18], Radulescu et al [19], Bianca et al [20,21], Ragusa and Russo [22], and to the references therein. For some models concerning stem cell transplantation, we mention the papers of Vincent et al [23], De Conde et al [24], Kim et al [25], Marciniak-Czochra and Stiehl [26], Precup et al. [27,28], Precup [29], and Stiehl et al [30].…”