Relapsing myocarditis following initial recovery of post COVID-19 vaccination in two adolescent males – Case reports

Amodio, Donato; Manno, Emma Concetta; Cotugno, Nicola; Santilli, Veronica; Franceschini, Alessio; Perrone, Marco Alfonso; Chinali, Marcello; Drago, Fabrizio; Cantarutti, Nicoletta; Curione, Davide; Engler, Renata J.M.; Secinaro, Aurelio

doi:10.1016/j.jvacx.2023.100318

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Furthermore, we primarily focused on the first occurrence of myocarditis/pericarditis post vaccination or infection. However, given the recent reports of recurrent myocarditis following mRNA COVID-19 vaccine despite a prior episode with full clinical recovery among adolescents [ 24 ], follow-up studies to comprehensively examine this phenomenon among both vaccine and infection-associated myocarditis cases are warranted.…”

Section: Discussionmentioning

confidence: 99%

A multiprovincial retrospective analysis of the incidence of myocarditis or pericarditis after mRNA vaccination compared to the incidence after SARS-CoV-2 infection

Naveed,

Chu,

Tadrous

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A multiprovincial retrospective analysis of the incidence of myocarditis or pericarditis after mRNA vaccination compared to the incidence after SARS-CoV-2 infection

Naveed,

Chu,

Tadrous

et al. 2024

Heliyon

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Susceptibility of SARS-CoV2 infection in children

Cotugno,

Amodio,

Buonsenso

et al. 2023

Eur J Pediatr

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Coronavirus disease 2019 in children presents with distinct phenotype in comparison to adults. Overall, the pediatric infection with a generally milder clinical course of the acute infection compared to adults still faces several unknown aspects. Specifically, the presence of a wide range of inflammatory manifestations, including multisystem inflammatory syndrome in children (MIS-C), myocarditis, and long COVID in the period after infection suggests a particular susceptibility of some children upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Albeit peculiar complications such as long covid are less frequent in children compared to adults, research on the relationship between inflammatory syndromes and SARS-CoV-2 is rapidly evolving. Conclusions: new studies and findings continue to emerge, providing further insights into the underlying mechanisms and potential therapeutic strategies. In the present work, we revised current knowledge of the main factors accounting for such variability upon SARS-CoV-2 infection over the pediatric age group. What is Known:• COVID19 in children overall showed a milder course compared to adults during the acute phase of the infection.• Children showed to be susceptible to a wide range of post infectious complications including multisystem inflammatory syndrome in children (MIS-C), myocarditis, neuroinflammation, and long COVID. What is New:• Mechanisms underlying susceptibility to a severe course of the infection were recently shown to pertain to the host. • A specific combination of HLA was recently shown to be associated to higher susceptibility to MIS-C in children.

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Tozinameran

2023

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Relapsing myocarditis following initial recovery of post COVID-19 vaccination in two adolescent males – Case reports

Cited by 4 publications

References 26 publications

A multiprovincial retrospective analysis of the incidence of myocarditis or pericarditis after mRNA vaccination compared to the incidence after SARS-CoV-2 infection

A multiprovincial retrospective analysis of the incidence of myocarditis or pericarditis after mRNA vaccination compared to the incidence after SARS-CoV-2 infection

Susceptibility of SARS-CoV2 infection in children

Tozinameran

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