Relating axonal injury to functional recovery in MS

Reddy, Hasini; Narayanan, Sridar; Matthews, Paul M.; Hoge, Rick; Pike, G. Bruce; Duquette, Pierre; Antel, Jack P.; Arnold, D. L.

doi:10.1212/wnl.54.1.236

Cited by 167 publications

(106 citation statements)

References 10 publications

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“…Previous fMRI studies have supported the existence of functional adaptive changes in MS patients during motor tasks [Filippi et al, 2002a,b;Lee et al, 2000a,b;Pantano et al, 2002;Reddy et al, 2000;Rocca et al, 2002;Yousry et al, 1998]. Generally, greater activations in patients have been [Filippi et al, 2002a,b;Lee et al, 2000a,b;Reddy et al, 2000;Rocca et al, 2002;Yousry et al, 1998].…”

Section: Discussionmentioning

confidence: 89%

“…Generally, greater activations in patients have been [Filippi et al, 2002a,b;Lee et al, 2000a,b;Reddy et al, 2000;Rocca et al, 2002;Yousry et al, 1998]. These results have been interpreted as a consequence of the recruitment of vicarious systems inside the ipsilateral hemisphere and recruitment of new motor units inside the controlateral hemisphere.…”

Section: Discussionmentioning

confidence: 99%

“…These results have been interpreted as a consequence of the recruitment of vicarious systems inside the ipsilateral hemisphere and recruitment of new motor units inside the controlateral hemisphere. Such cortical reorganization could limit the clinical expression of tissue damage [Cifelli andMatthews, 2002, Filippi et al, 2002a,b;Lee et al, 2000a,b;Reddy et al, 2000;Rocca et al, 2002]. Cortical reorganization also exists in other networks implied in high cognitive processes.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, numerous PET and fMRI studies have provided evidence that cortical plasticity may contribute to functional recovery after stroke, tumor, or brain trauma [Cao et al, 1999;Caramia et al, 1998;Chen et al, 2002;Cramer et al, 1997;Levine et al, 2002]. Adaptive cerebral plasticity of the cortical motor system may also limit the clinical expression of tissue impairment in MS [Filippi et al, 2002a,b;Lee et al, 2000a,b;Pantano et al, 2002;Reddy et al, 2000;Rocca et al, 2002;Staffen et al, 2002;Yousry et al, 1998]. This cortical motor reorganization would be present as soon as the earliest stage of MS, in patients with clinically isolated syndrome suggestive of MS (CISSMS) [Pantano et al, 2002].…”

Section: Introductionmentioning

confidence: 99%

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Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of multiple sclerosis

Audoin

Ibarrola

Ranjeva

et al. 2003

Human Brain Mapping

254

174

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Recent functional magnetic resonance imaging (fMRI) studies have suggested that functional cortical changes seen in patients with early relapsing-remitting multiple sclerosis (MS) can have an adaptive role to limit the clinical impact of tissue injury. To determine whether cortical reorganization occurs during high cognitive processes at the earliest stage of multiple sclerosis (MS), we performed an fMRI experiment using the conventional Paced Auditory Serial Addition Test (PASAT) as paradigm in a population of ten patients with clinically isolated syndrome suggestive of multiple sclerosis (CISSMS). At the time of the fMRI exploration, mean disease duration was 6.8 Ϯ 3.3 months. We compared these results to those obtained in a group of ten education-, age-, and sex-matched healthy controls. Subjects were explored on a 1.5 T MRI system using single-shot gradient-echo EPI sequence. Performances of the two groups during PASAT recorded inside the MR scanner were not different. Statistical assessment of brain activation was based on the random effect analysis (between-group analysis two-sample t-test P Ͻ 0.005 confirmed by individual analyses performed in the surviving regions P Ͻ 0.05 Mann Whitney U-test). Compared to controls, patients showed significantly greater activation in the right frontopolar cortex, the bilateral lateral prefrontal cortices, and the right cerebellum. Healthy controls did not show greater activation compared to CISSMS patients. The present study argues in favor of the existence of compensatory cortical activations at the earliest stage of MS mainly located in regions involved in executive processing in patients performing PASAT. It also suggests that fMRI can evidence the active processes of neuroplasticity contributing to mask the clinical cognitive expression of brain pathology at the earliest stage of MS. Hum. Brain

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of multiple sclerosis

Audoin

Ibarrola

Ranjeva

et al. 2003

Human Brain Mapping

254

174

View full text Add to dashboard Cite

show abstract

“…MS lesions can alter neuronal networks in several ways. Several fMRI studies have highlighted brain circuit plasticity and its potentially adaptive role in recovery or compensation in response to brain lesions (Reddy et al, 2000b), for motor (e.g. finger tapping) (Lee et al, 2000;Reddy et al, 2000a;Morgen et al, 2004) as well as cognitive tasks (e.g.…”

mentioning

confidence: 99%