Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

Denniss, Jonathan; Turpin, Andrew; McKendrick, Allison M

doi:10.1111/cxo.12844

Cited by 30 publications

(31 citation statements)

References 60 publications

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“… 3 , 4 Such applications (including routine clinical care) require spatial mapping between visual field space and relevant regions of interest on clinical imaging. 5 This article focuses on the problem of mapping peripapillary regions to visual field locations and updates our previous approach to custom mapping, taking into account newly available clinical data.…”

Section: Introductionmentioning

confidence: 99%

Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field

Turpin

McKendrick

2021

Trans. Vis. Sci. Tech.

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Section: Introductionmentioning

confidence: 99%

Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field

Turpin

McKendrick

2021

Trans. Vis. Sci. Tech.

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“…[16][17][18][19] Enface images offer the opportunity to relate structure and function without use of structure-function maps, thought to represent an additional source of noise in this relationship. 20 Indeed, newer perimetric strategies that aim to incorporate structural information for greater efficiency, [21][22][23] or that assess specific regions of interest in greater detail, [24][25][26] may be facilitated by enface imaging.…”

Section: Introductionmentioning

confidence: 99%

Depth‐resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes

Cheloni

Denniss

2020

Ophthalmic Physiologic Optic

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Purpose Recent developments in optical coherence tomography (OCT) technology enable direct enface visualisation of retinal nerve fibre bundle (RNFB) loss in glaucoma. However, the optimum depth at which to visualise RNFBs across the retina is unknown. We aimed to evaluate the range of depths and optimum depth at which RNFBs can be visualised across the retina in healthy eyes. Methods The central ± 25° retina of 10 healthy eyes from 10 people aged 57–75 years (median 68.5 years) were imaged with spectral domain OCT. Slab images of maximum axial resolution (4 μm) containing depth‐resolved attenuation coefficients were extracted from 0 to 193.5 μm below the inner limiting membrane (ILM). Bundle visibility within 10 regions of a superimposed grid was assessed subjectively by trained optometrists (n = 8), according to written instructions. Anterior and posterior limits of RNFB visibility and depth of best visibility were identified for each grid sector. Effects of retinal location and individual eye on RNFB visibility were explored using linear mixed modelling with likelihood ratio tests. Intraclass correlation coefficient (ICC) was used to measure overall agreement and repeatability of grading. Spearman’s correlation was used to measure correlation between depth range of visible RNFBs and retinal nerve fibre layer thickness (RNFLT). Results Retinal location and individual eye affected anterior limit of visibility (χ2(9) = 58.6 and 60.5, both p < 0.0001), but none of the differences exceeded instrument resolution, making anterior limit consistent across the retina and different eyes. Greater differences were observed in the posterior limit of visibility across retinal areas (χ2(9) = 1671.1, p < 0.0001) and different eyes (χ2(9) = 88.7, p < 0.0001). Optimal depth for visualisation of RNFBs was around 20 µm below the ILM in most regions. It varied slightly with retinal location (χ2(9) = 58.8, p < 0.0001), but it was not affected by individual eye (χ2(9) = 10.7, p = 0.29). RNFB visibility showed good agreement between graders (ICC 0.89, 95%CI 0.87–0.91), and excellent repeatability (ICC 0.96–0.99). Depth range of visible RNFBs was highly correlated with RNFLT (ρ = 0.9, 95%CI: 0.86–0.95). Conclusions The range of depths with visible RNFBs varies markedly across the healthy retina, consistently with RNFLT. To extract all RNFB information consistently across the retina, slab properties should account for differences across retinal locations and between individual eyes.

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“…The segmentation provides useful quantitative information about each individual layer of the retina. The objective measurements of macular thickness, ganglion cell-inner plexiform layer (GCL-IPL) thickness and peripapillary retinal nerve fiber layer (pRNFL) thickness provides valuable information in the diagnosis and follow up of patients with glaucoma, macular diseases and neurological disorders[4–8].…”

Section: Introductionmentioning

confidence: 99%

Repeatability of quantitative measurements of retinal layers with SD-OCT and agreement between vertical and horizontal scan protocols in healthy eyes

2019

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Purpose To evaluate the repeatability of the new spectral domain optical coherence tomography (HOCT-1F), and also to evaluate the agreement between vertical and horizontal scan protocols. In addition, we also evaluated the relation between the repeatability and age. Methods Three consecutive measurements of the inner limiting membrane–retinal pigment epithelium (ILM-RPE), inner limiting membrane–inner plexiform layer (ILM-IPL) from macular horizontal and vertical scans, and inner limiting membrane–retinal nerve fiber layer (ILM-RNFL) from optic disc horizontal scan. 159 subjects were included in the analysis. The within subject standard deviation (Sw) and the repeatability limits (R limit ) are used to represent the repeatability of the parameters for the different sectors. Results The Sw for the ILM-RPE thickness was less than 3.5 μm for each sector and scan direction. The Sw values varied within the sectors and scan modes, with horizontal scan modes resulting in better values for the horizontal sectors, and vice versa. The Sw for the GCL-IPL thickness was less than 2 μm, and was similar between the vertical and horizontal scan modes for each sector map. For the optic disc scan, the Sw was not symmetric along the clock-hour map sectors, the largest Sw values were seen in the vertical sectors (8.6 μm). The mean difference between the vertical and horizontal scans was less than 2 μm for each retinal thickness sector map. Significant but weak correlation between the Sw and the subject’s age was seen in both macular and optic disc scans. Conclusions The repeatability of the HOCT-1F to measure the ILM-RPE-, ILM-IPL- and ILM-RNFL-thickness is good. The repeatability of the ILM-RPE thickness is dependent on the scan direction, which should be taken into account when calculating retinal thickness. There is a weak correlation between the repeatability and the subject’s age.

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Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

Cited by 30 publications

References 60 publications

Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field

Improving Personalized Structure to Function Mapping From Optic Nerve Head to Visual Field

Depth‐resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes

Repeatability of quantitative measurements of retinal layers with SD-OCT and agreement between vertical and horizontal scan protocols in healthy eyes

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