Relating the number of human leucocytes antigen mismatches to pregnancy complications in oocyte donation pregnancies: study protocol for a prospective multicentre cohort study (DONOR study)

Bentem, Kim van; Lashley, Eileen; Bos, Manon; Eikmans, Michael; Heidt, Sebastiaan; Claas, Frans H.J.; Cessie, Saskia le; Hoorn, Marie-Louise van der

doi:10.1136/bmjopen-2018-027469

Cited by 5 publications

(5 citation statements)

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“…This is a multicentre cohort study designed to determine the association between fetal–maternal HLA mismatches and the development of hypertensive complications in pregnancy. 31 The study will be performed in seven fertility centres in the Netherlands, with the Leiden University Medical Center as coordinating centre.…”

Section: Methods and Analysismentioning

confidence: 99%

“… 42 For pregnancy check-ups and delivery, these women return to the Netherlands, which poses the opportunity of participation in our study. Currently, the DONOR cohort 31 consists of 300 OD pregnancies, of which data on fetal–maternal HLA matching is available for 150 pregnancies. To increase inclusion rate and to optimise representation of the Dutch population that applies to OD, also other centres that perform OD are approached for collaboration.…”

Section: Methods and Analysismentioning

confidence: 99%

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Development of the DONOR prediction model on the risk of hypertensive complications in oocyte donation pregnancy: study protocol for a multicentre cohort study in the Netherlands

Lafeber,

Van der Endt,

Louwers

et al. 2024

BMJ Open

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Introduction Oocyte donation (OD) pregnancy is accompanied by a high incidence of hypertensive complications, with serious consequences for mother and child. Optimal care management, involving early recognition, optimisation of suitable treatment options and possibly eventually also prevention, is in high demand. Prediction of patient-specific risk factors for hypertensive complications in OD can provide the basis for this. The current project aims to establish the first prediction model on the risk of hypertensive complications in OD pregnancy. Methods and analysis The present study is conducted within the DONation of Oocytes in Reproduction project. For this multicentre cohort study, at least 541 OD pregnancies will be recruited. Baseline characteristics and obstetric data will be collected. Additionally, one sample of maternal peripheral blood and umbilical cord blood after delivery or a saliva sample from the child will be obtained, in order to determine the number of fetal–maternal human leucocyte antigen mismatches. Following data collection, a multivariate logistic regression model will be developed for the binary outcome hypertensive complication ‘yes’ and ‘no’. The Prediction model Risk Of Bias ASsessment Tool will be used as guide to minimise the risk of bias. The study will be reported in line with the ‘Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis’ guideline. Discrimination and calibration will be determined to assess model performance. Internal validation will be performed using the bootstrapping method. External validation will be performed with the ‘DONation of Oocytes in Reproduction individual participant data’ dataset. Ethics and dissemination This study is approved by the Medical Ethics Committee LDD (Leiden, Den Haag, Delft), with protocol number P16.048 and general assessment registration (ABR) number NL56308.058.16. Further results will be shared through peer-reviewed journals and international conferences.

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Section: Methods and Analysismentioning

confidence: 99%

Section: Methods and Analysismentioning

confidence: 99%

Development of the DONOR prediction model on the risk of hypertensive complications in oocyte donation pregnancy: study protocol for a multicentre cohort study in the Netherlands

Lafeber,

Van der Endt,

Louwers

et al. 2024

BMJ Open

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“…To estimate a causal relation between OD pregnancy and the development of hypertensive complications using observational studies, adjustment in the analyses is of high importance. Possible associated covariates are visualised in a directed acyclic graph previously published in the protocol for the DONOR study, 34 highlighting the confounding factors that need to be adjusted. These confounding factors include maternal age, ethnicity and plurality.…”

Section: Methodsmentioning

confidence: 99%

Development of hypertensive complications in oocyte donation pregnancy: protocol for a systematic review and individual participant data meta-analysis (DONOR IPD)

et al. 2022

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IntroductionThe assisted reproductive technique of oocyte donation (OD) is comparable to in vitro fertilisation (IVF), with the distinction of using a donated oocyte and thus involving two women. Compared with IVF and naturally conceived (NC) pregnancies, OD pregnancies have a higher risk for pregnancy complications as pregnancy-induced hypertension (PIH) and pre-eclampsia (PE). Various covariates among women pregnant by OD, however, also contribute to an increased risk for developing hypertensive complications. Therefore, we will conduct the DONation of Oocytes in Reproduction individual participant data (DONOR IPD) meta-analysis to determine the risk for the development of hypertensive complications in OD pregnancy, in comparison to autologous oocyte pregnancy (non-donor IVF/intracytoplasmic sperm injection (ICSI) and NC pregnancy). The DONOR IPD meta-analysis will provide an opportunity to adjust for confounders and perform subgroup analyses. Furthermore, IPD will be used to externally validate a prediction model for the development of PE in OD pregnancy.Methods and analysisA systematic literature search will be performed to search for studies that included women pregnant by OD, and documented on hypertensive complications in OD pregnancy. The authors from each study will be asked to collaborate and share IPD. Using the pseudoanonymised combined IPD, we will perform statistical analyses with one-stage and two-stage approaches, subgroup analyses and possibly time-to-event analyses to investigate the risk of developing hypertensive complications in OD pregnancy. Furthermore, we will formally assess a prediction model on its performance in an external validation with the use of IPD.Ethics and disseminationEthical approval and individual patient consent will not be required in most cases since this IPD meta-analysis will use existing pseudoanonymised data from cohort studies. Results will be disseminated through peer-reviewed journals and international conferences.PROSPERO registration numberCRD42021267908.

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“…ũſƊſžƍƋƟƆ żƅźƋƇſ žƈƇźƐƟƘ ƈƈƐƂƌƟż ƉƊƈƉƈƇƍżźƅƂ Ɵ ƁźƊźƁ źƄƌƂżƇƈ żƂƄƈƊƂƋƌƈżƍƘƌƖ žƅƙ ƉźƐƟƝƇƌƈƄ, ƍ ƙƄƂƏ ƇſƆƈƀ-ƅƂżƈ ƈƌƊƂƆźƌƂ żƅźƋƇƟ ƈƈƐƂƌƂ ƇźƅſƀƇƈƠ ƙƄƈƋƌƟ. ŞƈƋƂƌƖ ƊƟƁƇƈƊƟžƇź ŽƊƍƉź ƀƟƇƈƄ żƄƅƘƑźƝ ƌƂƏ, ƙƄƟ ƆźƘƌƖ ŽſƇſƌƂƑƇƟ źƇƈƆźƅƟƠ, Ɠƈ żƂƄƅƂƄźƘƌƖ ƉƈƊƍ-ƒſƇƇƙ ƊƈƁżƂƌƄƍ ŽƈƇźž Ɵ/źŻƈ ƈŻƍƆƈżƅƘƘƌƖ Ɖſ-ƊſžƑźƋƇſ żƂƋƇźƀſƇƇƙ ƙƝƑƇƂƄƟż; ƉźƐƟƝƇƌƈƄ, Ɠƈ ƁźƁƇźƅƂ ƌƊźżƆźƌƂƑƇƈŽƈ żƉƅƂżƍ Ƈź ƌƄźƇƂƇƂ ƙƝƑ-ƇƂƄƟż ƙƌƊƈŽſƇƇƈŽƈ ƯſƇſƁƍ (ƏƟƆƟƈ-, ƊƟžƟƈƌſƊźƉƟƙ, ƈƉſƊźƐƟƠ Ƈź ƉƊƂžźƌƄźƏ) [14] (ƍ ƌźƄƈƆƍ ƊźƁƟ ƉƅƟž ƁźƁżƂƑźƃ ƇźƁƂżźƘƌƖ ƋſƆƟźƅƈ-ŽſƇƇƂƆ) [56].…”

mentioning

confidence: 99%

“…ŨƑƟƄƍżźƇƈ, Ɠƈ żźŽƟƌƇƟƋƌƖ, ƙƄź ƇźƋƌźƅź Ɓ żƂ-ƄƈƊƂƋƌźƇƇƙƆ žƈƇƈƊƋƖƄƈŽƈ ƈƈƐƂƌź, żƂƆźŽźƌƂƆſ żƟž ƈƊŽźƇƟƁƆƍ ƀƟƇƄƂ ƉƈƋƂƅſƇƈŽƈ ƁźžƟƙƇƇƙ ƊƟƁ-ƇƈƆźƇƟƌƇƂƏ ƆſƏźƇƟƁƆƟż ƌƈƅſƊƍżźƇƇƙ ŽſƇſƌƂƑƇƈ ƑƍƀƈƊƟžƇƈŽƈ ƆźƌſƊƟźƅƍ, ƠƏ «żƂžƈƁƆƟƇſƇſ» ƎƍƇƄ-ƐƟƈƇƍżźƇƇƙ [56].…”

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Modern view on the prevention of obstetric and perinatal complications in pregnant women with allogeneic fetus

Romanenko¹,

Yesyp²

2022

UJHW

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The widespread use of assisted reproductive technologies is owed to the rapid development of biomedical science. However, progress is accompanied by a steady decline in the reproductive health of the population, so the lack of knowledge today on theoretical and practical aspects remains significant. Despite the improvement of donor oocyte manipulation techniques and the outstanding success in obstetric and perinatal outcomes in cases of pregnancies with fully allogeneic fetus, the actual data on the incidence of complications of pregnancy, childbirth and postpartum period in this category of patients remain unclear. Purpose - to analyze the results of obstetric and perinatal complications in pregnant women with allogeneic fetuses, and factors that may affect them. This article summarizes the current data on obstetric and perinatal complications in pregnant women with allogeneic fetus, analyzes the biological preconditions for their occurrence, features of the fetoplacental complex in such patients, as well as the psychological status of pregnant women with allogeneic fetus, it’s potential impact on pregnancy, childbirth and the postpartum period. No conflict of interests was declared by the authors.

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Relating the number of human leucocytes antigen mismatches to pregnancy complications in oocyte donation pregnancies: study protocol for a prospective multicentre cohort study (DONOR study)

Cited by 5 publications

References 34 publications

Development of the DONOR prediction model on the risk of hypertensive complications in oocyte donation pregnancy: study protocol for a multicentre cohort study in the Netherlands

Development of the DONOR prediction model on the risk of hypertensive complications in oocyte donation pregnancy: study protocol for a multicentre cohort study in the Netherlands

Development of hypertensive complications in oocyte donation pregnancy: protocol for a systematic review and individual participant data meta-analysis (DONOR IPD)

Modern view on the prevention of obstetric and perinatal complications in pregnant women with allogeneic fetus

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