Relation between acute kidney injury and pregnancy-related factors

Siribamrungwong, Monchai; Chinudomwong, Pawadee

doi:10.1016/j.joad.2015.08.002

Cited by 27 publications

(25 citation statements)

References 26 publications

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“…Studies revealed that preeclampsia and eclampsia accounted for most of PRAKI cases. 5 There are many biomarker studies for AKI prediction. One of them is serum neutrophil gelatinase-associated lipocalin (NGAL).…”

Section: Introductionmentioning

confidence: 99%

Association of serum neutrophil gelatinase associated lipocalin (NGAL) levels with preeclampsia

Dhivya

Mathew

Jeyachandran³

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia is a systemic disorder that affects multiple organs and is characterized by the new onset of hypertension and proteinuria or end-organ dysfunction or both in the second half of pregnancy. NGAL is a 25-KDa protein of the lipocalin family and is considered to be a novel biomarker for ischemic injury. The objective of this study is to compare the levels of serum NGAL in preeclamptic patients and gestational age matched normotensive controls.Methods: The study design is case control study in which pregnant women with preeclampsia (n=40) are selected as cases. Cases were selected from pregnant women attending OG-OPD and IP satisfying the inclusion criteria and not coming under exclusion criteria. 0.5ml of blood was collected in vacutainers and was centrifuged at 3500rpm for 10 minutes. The serum thus separated was aliquoted into smaller plain containers and stored at -20 degree Celsius for analysis. The urine sample was also collected. Controls were also selected from the OP patients.Results: In present study, the serum NGAL ranged from 40-900ng/ml in cases and from 110-795ng/ml in controls. There is no difference in NGAL between cases and control. The correlation coefficients between the NGAL levels and other parameters like maternal age, gestational age, systolic Blood pressure, diastolic Blood pressure, uric acid levels, urine PCR are also not statistically significant.Conclusions: Serum NGAL levels are not significantly elevated in patients with preeclampsia when compared with the normotensive controls and also there is no significant correlation between serum NGAL levels and other assessed parameters.

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Section: Introductionmentioning

confidence: 99%

Association of serum neutrophil gelatinase associated lipocalin (NGAL) levels with preeclampsia

Dhivya

Mathew

Jeyachandran³

2019

Int J Reprod Contracept Obstet Gynecol

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“…In low‐resource countries, by contrast, the incidence of pregnancy‐related AKI remains high; obstetric causes, septicemia, and nephrotoxins are the principal causes of AKI and are significantly associated with morbidity and mortality in these settings . Pregnancy‐related AKI accounts for 1.0%–2.8% of all cases of AKI in high‐income countries, but for 9%–25% in low‐income countries …”

Section: Introductionmentioning

confidence: 99%

“…Hypertensive disorders of pregnancy (pre-eclampsia/eclampsia or HELLP syndrome) are the leading cause of AKI in pregnancy worldwide. 3 Although the great majority of patients with pre-eclampsia or eclampsia do not develop AKI, if neglected, this spectrum of disorders can progress to AKI. Globally, the incidence of AKI resulting from preeclampsia/eclampsia is 1.5%-2%.…”

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confidence: 99%

Profile and outcomes of women with pregnancy‐related acute kidney injury requiring dialysis at a center in Ethiopia

Bekele

Ahmed

Aliyu³

et al. 2017

Intl J Gynecology & Obste

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“…However, PE is more common in renal donors [141]. Acute kidney injury (AKI) is a serious problem during pregnancy and understanding the physiological kidney adaptation during pregnancy is essential for early detection, diagnosis, and appropriate management to prevent obstetric complications [142]. In pregnant women with type I diabetes mellitus (T1DM) at increased PE risk, urine albumin examination should be performed to prevent kidney complications [143].…”

Section: Kidney Disease In Pementioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Preeclampsia (PE) have a high risk of pregnancy disorder and can cause liver and kidney disease. PE is a dangerous disease in Indonesia with a high risk of cardiovascular death. PE has biomarkers such as proteinuria, blood pressure, dipstick test, renin-angiotensin system, adipsin, calcium/ creatinine (Cr) ratio, albumin/Cr ratio, and uric acid. Apoptosis occurs in the placenta’s PE, where trophoblasts invade and overhaul the uterine spiral artery in the epidermal growth factor signaling system, and the expression of miRNA in PE is targeting genes in a variety of pathophysiological processes can cause kidney and hepatic disease. In this review, we will discuss role of HSP, miRNA, Immunology cell and the risk of kidney and hepatic disease of patient of Preeclampsia.

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Relation between acute kidney injury and pregnancy-related factors

Cited by 27 publications

References 26 publications

Association of serum neutrophil gelatinase associated lipocalin (NGAL) levels with preeclampsia

Association of serum neutrophil gelatinase associated lipocalin (NGAL) levels with preeclampsia

Profile and outcomes of women with pregnancy‐related acute kidney injury requiring dialysis at a center in Ethiopia

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

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