Relation between adverse drugs reactions with potentially inappropriate prescription in hospitalized older adults

Abstract

Endpoint:The aim of the study was to analyze the relationship between adverse drug reactions (ADRs) and potentially inappropriate prescriptions (PIPs) in hospitalized older adults. Methods: This was an observational, cross-sectional, and retrospective study. Older adults hospitalized in the Cardiology department between June 2019 and January 2020 were included in the study. PIPs were determined using the Beers and Screening Tool of Older Person's Prescriptions (STOPP)/Screening Tool to Alert doctors to Right appropriate, indicated Treatment (START) criteria. A review of clinical records was carried out to identify principal ADRs to analyze their relationship using Chi-square, Mann-Whitney U test, and odds ratio on statistical software Statistical Package for the Social Sciences v22. Results: Five hundred and eighty-four patients were included in the study; 56% male, with a median age of 76 years. The prevalence of PIPs and ADRs was 46% and 64%, respectively. The PIPs demonstrated an odds ratio: 2.45 confidence interval (1.71-3.45), p = 0.0001 for ADRs. The prescription tools showed an adequate diagnostic value for ADRs with the following characteristics: Beers Criteria (sensibility: 37%, specificity: 81%) and STOPP Criteria (sensibility: 29%, specificity: 84%). Conclusions: PIPs were related to ADRs during the hospitalization, showing that the Beers Criteria and STOPP Criteria are adequate diagnostic value tools. Originality: First study in a Mexican population was to evaluate the relationship between PIPs and ADRs in hospitalized older patients.