Relation between altered sodium-lithium countertransport kinetics and severity of vascular disease

Hardman, Timothy C.; Barlow, R.; Croft, Phyllis G.; Wierzbicki, A. S.; Dubrey, SW; Fehér, M; Lant, A. F.

doi:10.1016/0021-9150(95)96724-7

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated cholesterol does not appear to have an effect on SLC in vim. Altered SLC activity has been suggested to be an intermediate phenotype of cardiovascular risk in several previous studies [9,14,15,271. Whether this is due to modulation by insulin receptor activity, or rather reflects a more fundamental disorder of membrane structure which predisposes to the insulin resistance syndrome but can be influenced by plasma lipids, remains to be fully elucidated.…”

Section: Discussionmentioning

confidence: 96%

“…Variable effects of plasma lipids on membrane lipid composition in different individuals have been demonstrated [30, 421, suggesting that factors other than plasma lipid levels may also be important. A correlation between SLC activity and triacylglycerols has been shown in normal individuals [14,22,431, and in hypertension [15], diabetes mellitus [24] and diabetic nephropathy [44].…”

Section: Discussionmentioning

confidence: 99%

“…SLC has been shown to be elevated in patients with essential hypertension [ 131, with dyslipidaemia exerting an independent effect [ 151. In clinical studies standard SLC has been correlated with triacylglycerol levels [14,191 while some have also found an association with cholesterol [16,201, and a negative correlation with high-density lipoprotein (HDL) [15, 211. Other studies of essential hypertension have failed to find any significant relationship between SLC and plasma lipid levels [22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sodium—Lithium Countertransport, Sodium—Hydrogen Exchange and Membrane Microviscosity in Patients with Hyperlipidaemia

et al. 1997

View full text Add to dashboard Cite

1. We measured sodium-lithium countertransport, sodium-hydrogen exchange and membrane micro-viscosity in 48 individuals with familial hypercholesterolaemia, 33 subjects with hypertriglyceridaemia and 54 normolipaemic controls. Full lipid profile, blood pressure, body mass index, fasting glucose and insulin levels were also measured. 2. Subjects with hypertriglyceridaemia had higher blood pressure, body mass index, fasting glucose and insulin levels than normal controls. 3. Vmax of the sodium-lithium countertransport was elevated in the hypertriglyceridaemic group compared with controls. Across the whole group log(e) triacylglycerols correlated with Vmax of the sodium-lithium countertransport. There was no difference in sodium-lithium countertransport K(m) between the groups. 4. Sodium-hydrogen maximal proton efflux rate (Vmax) and K(m) were not different between the three groups. There were no correlations between sodium-hydrogen exchange and sodium-lithium countertransport parameters. 5. Microviscosity as measured by diphenylhexatriene was reduced at the core of the membrane in subjects with hypertriglyceridaemia compared with those with familial hypercholesterolaemia or normolipaemic controls, suggesting an alteration in membrane structure. 6. Changes in sodium transport in hyperlipidaemia may be mediated by changes in membrane structure resulting in altered protein conformation or turnover.

show abstract

Section: Discussionmentioning

confidence: 96%