Relation Between Angiographic Lesion Severity, Vulnerable Plaque Morphology and Future Adverse Cardiac Events (from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree Study)

Yun, Kyeong Ho; Mintz, Gary S.; Farhat, Naim; Marso, Steven P.; Taglieri, Nevio; Verheye, Stefan; Foster, Michael; Margolis, M. Pauliina; Templin, Barry; Xu, Ke; Dressler, Ovidiu; Mehran, Roxana; Stone, Gregg W.; Maehara, Akiko

doi:10.1016/j.amjcard.2012.04.018

Cited by 42 publications

(30 citation statements)

References 16 publications

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“…21 The PROSPECT study demonstrated that virtual histology IVUS-derived thin-capped fibroatheroma (ie, a fibroatheroma without evidence of a fibrous cap that possessed a >10% confluent necrotic core with a >30° necrotic core abutting the lumen) predicted lesion-specific events during 3 years of follow-up. 22 Several other studies have also demonstrated that tissue characteristics have a great impact on coronary plaque vulnerability. 23-25 Recent preliminary in vitro studies showed that IB values reflect the structural and biochemical compositions of atherosclerotic lesions and can differentiate fibrofatty, fatty, and calcified lesions of arterial walls.…”

Section: Discussionmentioning

confidence: 98%

Plasma Glucagon-Like Peptide-1 and Tissue Characteristics of Coronary Plaque in Non-Diabetic Acute Coronary Syndrome Patients

Mitsuhashi

Hibi

Konishi

et al. 2016

Circ J

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Section: Discussionmentioning

confidence: 98%

Plasma Glucagon-Like Peptide-1 and Tissue Characteristics of Coronary Plaque in Non-Diabetic Acute Coronary Syndrome Patients

Mitsuhashi

Hibi

Konishi

et al. 2016

Circ J

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“…Anatomical severity of coronary lesions is associated with adverse outcomes (123). The fractional flow reserve (FFR) has emerged as the reference tool for the assessment of functional severity of coronary lesions.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes in Patients with Deferred Coronary Lesions according to Disease Severity Assessed by Fractional Flow Reserve

et al. 2016

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Data on the clinical outcomes in deferred coronary lesions according to functional severity have been limited. This study evaluated the clinical outcomes of deferred lesions according to fractional flow reserve (FFR) grade using Korean FFR registry data. Among 1,294 patients and 1,628 lesions in Korean FFR registry, 665 patients with 781 deferred lesions were included in this study. All participants were consecutively categorized into 4 groups according to FFR; group 1: ≥ 0.96 (n = 56), group 2: 0.86–0.95 (n = 330), group 3: 0.81–0.85 (n = 170), and group 4: ≤ 0.80 (n = 99). Primary endpoint was major adverse cardiac events (MACE), a composite of all-cause death, myocardial infarction, and target vessel revascularization. The median follow-up period was 2.1 years. During follow-up, the incidence of MACE in groups 1–4 was 1.8%, 7.6%, 8.8%, and 13.1%, respectively. Compared to group 1, the cumulative rate by Kaplan-Meier analysis of MACE was not different for groups 2 and 3. However, group 4 had higher cumulative rate of MACE compared to group 1 (log-rank P = 0.013). In the multivariate Cox hazard models, only FFR (hazard ratio [HR], 0.95; P = 0.005) was independently associated with MACE among all participants. In contrast, previous history of percutaneous coronary intervention (HR, 2.37; P = 0.023) and diagnosis of acute coronary syndrome (ACS) (HR, 2.35; P = 0.015), but not FFR, were independent predictors for MACE in subjects with non-ischemic (FFR ≥ 0.81) deferred coronary lesions. Compared to subjects with ischemic deferred lesions, clinical outcomes in subjects with non-ischemic deferred lesions according to functional severity are favorable. However, longer-term follow-up may be necessary.

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“…Indeed, computerassisted evaluation of RVT could minimize operator-dependent variability, and previous studies have suggested that thrombus echogenicity may be correlated with its histological characteristics. 34,35 The clinical relevance of this strategy has been previously demonstrated in studies of arterial thrombosis. 11,14,15 In fact, our results demonstrated that the echogenicity of RVT may be an auxiliary parameter to detect patients at risk for recurrence.…”

Section: Discussionmentioning

confidence: 94%

Residual Vein Thrombosis Echogenicity Is Associated to the Risk of DVT Recurrence: A Cohort Study

Mazetto

Orsi

Silveira

et al. 2017

Clin Appl Thromb Hemost

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Although deep vein thrombosis (DVT) recurrence is a common late complication of the disease, there are few predictive markers to risk-stratify patients long-term after the thrombotic event. The accuracy of residual vein thrombosis (RVT) in this context is controversial, possibly due to a lack of a standardized methodology. The objective of the study was to evaluate the accuracy of RVT echogenicity as a predictive marker of late DVT recurrence. To evaluate the accuracy of RVT echogenicity as a predictive marker of late DVT recurrence. This prospective study included patients with history of DVT in the past 33 months. Ultrasound examination was performed to detect the presence of RVT, and its echogenicity was determined by calculating the grayscale median (GSM) of the images. Blood samplings were taken for plasma D-dimer levels. Patients were followed-up for 28 months and the primary end point was DVT recurrence. Deep vein thrombosis recurrence was confirmed or excluded by ultrasound during the follow-up. Fifty-six patients were included, of which 10 presented DVT recurrence during the follow-up. D-dimer levels above 630 ng/mL conferred higher risk for recurrence with a negative predictive value of 94%. The absence of RVT was a protective marker for recurrence with a negative predictive value of 100%. Also, the presence of hypoechoic RVT, determined by GSM values below 24, positively predicted 75% of DVT recurrences. Our results suggest that the persistence of RVT and, particularly, the presence of hypoechoic thrombi (GSM < 24) are predictive markers of the risk of DVT recurrence. Residual vein thrombosis echogenicity, by GSM analysis, could represent a new strategy for the evaluation of recurrence risk in patients with DVT.

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Relation Between Angiographic Lesion Severity, Vulnerable Plaque Morphology and Future Adverse Cardiac Events (from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree Study)

Cited by 42 publications

References 16 publications

Plasma Glucagon-Like Peptide-1 and Tissue Characteristics of Coronary Plaque in Non-Diabetic Acute Coronary Syndrome Patients

Plasma Glucagon-Like Peptide-1 and Tissue Characteristics of Coronary Plaque in Non-Diabetic Acute Coronary Syndrome Patients

Clinical Outcomes in Patients with Deferred Coronary Lesions according to Disease Severity Assessed by Fractional Flow Reserve

Residual Vein Thrombosis Echogenicity Is Associated to the Risk of DVT Recurrence: A Cohort Study

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