Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: <scp>A</scp> multicenter study of 2283 cases

Matsuhisa, Takeshi; Arakawa, Tetsuo; Watanabe, Tetsuo; Tokutomi, Tadashi; Sakurai, Katsunobu; Okamura, Seisuke; Chono, Shinji; Kamada, Takenobu; Sugiyama, Atsushi; Fujimura, Yoshinori; Matsuzawa, Kenji; Ito, Masanori; Yasuda, Mitsugu; Ota, Hiroyoshi; Haruma, Ken

doi:10.1111/den.12030

Cited by 79 publications

(74 citation statements)

References 18 publications

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“…In line with Rutledge et al's findings, no EGJ function and motility abnormalities were observed after OGB. In addition, for the first time we documented a drastic reduction not only in esophageal acid exposure time but also in all kinds of refluxes (acidic, weakly acidic, and (3)(4)(5) .000 26 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) 38 .000 Recumbent 9 (2-16) 0 (0-2) .000 7 (4-9) 15 (10)(11)(12)(13)(14)(15)(16)(17) .000 Acid reflux pattern at MII Total 32 (15-50) 3 (3)(4)(5)(6) .000 12 (9)(10)(11)(12)(13)(14) 16 (9--18) .000 Upright 27 (13-37) 3 (3)(4) .008 9 (8-10) 13 (7)(8)(9)(10)(11)(12)(13)(14)…”

Section: Discussionmentioning

confidence: 71%

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Effects of omega-loop bypass on esophagogastric junction function

Tolone

Cristiano²,

Savarino

et al. 2016

Surgery for Obesity and Related Diseases

123

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Section: Discussionmentioning

confidence: 71%

“…Although duodenogastric bile reflux is a physiologic phenomenon [19,20], excessive duodenogastric biliary reflux can lead to intestinal metaplasia, esophageal mucosal damage, symptomatic gastritis/ esophagitis, Barrett's esophagus, and gastric/esophageal cancer [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Effects of omega-loop bypass on esophagogastric junction function

Tolone

Cristiano²,

Savarino

et al. 2016

Surgery for Obesity and Related Diseases

123

View full text Add to dashboard Cite

“…Причём в одних данных не найдено связи её развития с хе-ликобактерной инфекцией [6], в других ра-ботах показано, что риск развития интести-нальной метаплазии при ДГР повышается при наличии хеликобактерной инфекции, а при её отсутствии ДГР не приводит к дан-ным морфологическим изменениям [7].…”

Section: Morphological Characteristics Of Reflux Gastritisunclassified

“…В отношении гландулярной атрофии в наибольшем количестве встретившихся нам работ указано, что рефлюкс-гастрит нельзя считать фактором риска её развития [6]. Однако в других работах было показа-но, что ДГР не только является причиной развития атрофии СОЖ, но и по-разному воздействует на развитие атрофии на раз-ных уровнях желудка.…”

Section: Morphological Characteristics Of Reflux Gastritisunclassified

“…Так, не-которые исследователи заявляют о том, что при наличии H. pylori степень ДГР увели-чивается [7,14]. Однако в других работах не было найдено различий по степени ДГР у H. pylori-позитивных и негативных пациен-тов [6,15]. Наши данные свидетельствуют в пользу второго мнения.…”

Section: сопутствующая патология органов пищеварения у пациентов с дуunclassified

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Morphological characteristics of reflux gastritis

et al. 2017

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Aim. To study morphological features of gastric mucosa in duodenogastric reflux and the connection of the latter with the level of acidity of gastric contents, presence of H. pylori infection and contractile function of the gallbladder. Methods. 65 patients were examined: 10 people were included in control group, and in 55 patients reflux gastritis was identified according to gastrointestinal endoscopy. Gastric contents were analyzed for the level of acidity and concentration of bile acids. For all patients histological examination of biopsy material of gastric mucosa at the level of the body and antrum was performed. Results. Correlation between the acidity level and the concentration of bile acids in gastric contents taken from an empty stomach was found (r=-0.408; p=0.033). In patients with H. pylori pH-level was higher compared to the control group (p=0.047), at the same time the level of bile acids had no significant difference in both groups. Discharge coefficient of the gallbladder in patients with duodenogastric reflux did not differ from the control group. In patients with duodenogastric reflux significant differences from the control group were found in the rate of such morphological signs as chronic inflammatory cell infiltration (p=0.013) and mucosal edema (p=0.032) at the level of the antrum, foveolar hyperplasia at the level of the body of the stomach (p=0.0315). Conclusion. The degree of duodenogastric reflux has a correlation with acidity of gastric juice; presence or absence of H. pylori does not affect the degree of duodenogastric reflux in primary reflux gastritis; pathomorphological features of duodenogastric reflux are gastric mucosa edema and chronic inflammation at the level of the antrum, foveolar hyperplasia at the level of the body of stomach.

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Bile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis

et al. 2022

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Bile reflux gastritis (BRG) is associated with the development of gastric cancer (GC), but the specific mechanism remains elusive. Here, a comprehensive study is conducted to explore the roles of refluxed bile acids (BAs) and microbiome in gastric carcinogenesis. The results show that conjugated BAs, interleukin 6 (IL‐6), lipopolysaccharide (LPS), and the relative abundance of LPS‐producing bacteria are increased significantly in the gastric juice of both BRG and GC patients. A secondary BA, taurodeoxycholic acid (TDCA), is significantly and positively correlated with the LPS‐producing bacteria in the gastric juice of these patients. TDCA promotes the proliferation of normal gastric epithelial cells (GES‐1) through activation of the IL‐6/JAK1/STAT3 pathway. These results are further verified in two mouse models, one by gavage of TDCA, LPS, and LPS‐producing bacteria (Prevotella melaninogenica), respectively, and the other by bile reflux (BR) surgery, mimicking clinical bile refluxing. Moreover, the bile reflux induced gastric precancerous lesions observed in the post BR surgery mice can be prevented by treatment with cryptotanshinone, a plant‐derived STAT3 inhibitor. These results reveal an important underlying mechanism by which bile reflux promotes gastric carcinogenesis and provide an alternative strategy for the prevention of GC associated with BRG.

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Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: A multicenter study of 2283 cases

Abstract: High concentrations of bile acid seem to be associated with an elevated risk of intestinal metaplasia.

Cited by 79 publications

References 18 publications

Effects of omega-loop bypass on esophagogastric junction function

Effects of omega-loop bypass on esophagogastric junction function

Morphological characteristics of reflux gastritis

Bile Acid–Microbiome Interaction Promotes Gastric Carcinogenesis

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